Top Tech Jobs & Startup Jobs in Boston, MA

The Principal Backend Developer leads the design and architecture of backend systems, ensuring scalability and reliability while mentoring engineers and engaging with cross-functional teams.

Conduct in vitro studies on novel somatic variants related to Cardiometabolic disease, performing experiments, analyzing data, and collaborating with scientists.

Lead computational design and optimization of synthetic Synteins by creating structure-guided and ML-enabled design strategies, executing engineering campaigns, collaborating with chemistry and experimental teams, and integrating structural and biophysical data into iterative optimization cycles.

Build predictive and generative ML models to design and optimize non‑natural amino‑acid Synteins. Integrate experimental datasets, collaborate with chemists and biologists, prioritize libraries for synthesis/screening, and contribute to ML pipelines, data infrastructure, and model validation for a closed‑loop discovery platform.

The Principal Scientist will lead in vitro pharmacology efforts, develop cell-based assays, mentor junior scientists, and drive discovery programs.

The Operating Principal will lead operations and strategy in biotech firms, focusing on corporate development, team management, and aligning scientific goals with business objectives.

The Cryo-EM Scientist processes cryo-EM data, builds atomic models, troubleshoots workflows, communicates results, and collaborates across teams.

The Director/Senior Director oversees digital strategy and coordination between business units and IT, supporting biotech growth initiatives and managing digital transformations.

Lead design, engineering, expression, and high-throughput discovery of peptide and protein binders to small molecules. Build screening workflows, run quantitative biophysical assays, and drive DBTL optimization with computational support.

As SVP - AI & Digital Platform, you will lead AI and digital tech initiatives, develop strategies, and build platforms for efficiency across Flagship's operations.