Top Senior Python Jobs in Boston, MA

Reposted 3 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead diverse technology projects in distributed microservices and full stack systems, mentoring team members and collaborating with product managers on cloud-based solutions.
Top Skills: AWSCSSDockerGoGCPHTMLJavaJavaScriptKubernetesAzureNosql DatabasesOpen Source RdbmsPythonSQLTypescript
Reposted 4 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team to develop distributed systems using Golang and Python on Kubernetes, collaborate on AI/ML solutions, and drive technological innovation.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesNoSQLPythonRdbmsSQLTypescript
Reposted 6 Days AgoSaved
Hybrid
Boston, MA
179K-225K Annually
Senior level
179K-225K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team of developers to build technology projects using microservices and full stack systems, focusing on cloud-based solutions and mentoring team members.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesPysparkPythonSQLTypescript
Reposted 11 Days AgoSaved
Easy Apply
Hybrid
Boston, MA
Easy Apply
90K-210K Annually
Senior level
90K-210K Annually
Senior level
Aerospace • Artificial Intelligence • Computer Vision • Machine Learning • Natural Language Processing • Software • Defense
Design, develop, and maintain scalable, reliable Python applications. Participate in design and code reviews, collaborate with engineers and data scientists, adopt microservices and containerization, follow Agile practices, and support deployment and integration for DoD-focused AI/ML and simulation projects.
Top Skills: AWSAzureContainerizationDevops ToolsDockerDocker-ComposeGCPGitKanbanKubernetesMicroservice ArchitecturePysparkPythonRelational DatabasesScrumSpark
Reposted 8 Days AgoSaved
Easy Apply
Remote or Hybrid
Boston, MA
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
Reposted 18 Days AgoSaved
Hybrid
Boston, MA
209K-286K Annually
Senior level
209K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a portfolio of technology projects with a team of developers to create solutions for regulatory needs, collaborating on cloud-based projects while mentoring engineers.
Top Skills: Amazon SagemakerAWSCSSDatabricksDockerGoHTMLJavaJavaScriptKubernetesLuaMcpPythonSQLTypescript
Reposted 4 Days AgoSaved
In-Office
Boston, MA
60K-80K Annually
Senior level
60K-80K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Develop Python-based solutions performing SQL/CRUD operations, file extraction/transformation/generation (CSV, XML, JSON, PDF), and email integration. Work in an onsite/offshore model, collaborate with teams, communicate clearly, and perform under pressure for contract assignments.
Top Skills: CsvDatabaseEmail IntegrationJSONPdfPythonSQLXML
6 Days AgoSaved
In-Office
Boston, MA
100K-150K Annually
Senior level
100K-150K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Design, build, and maintain enterprise-grade Python applications and data-intensive services. Own architecture, performance tuning, data processing (batch and near-real-time), production troubleshooting, CI/CD and observability. Mentor engineers, conduct code reviews, collaborate with product/data/infrastructure teams, and support incident response to improve reliability and maintainability.
Top Skills: Ci/CdMs Sql ServerOraclePostgresPythonSybase
Reposted 16 Hours AgoSaved
Remote or Hybrid
Boston, MA
Senior level
Senior level
Digital Media • Social Media • Software • Design
Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.
Top Skills: Python
Reposted 21 Hours AgoSaved
Remote
Boston, MA
Senior level
Senior level
Software
Senior iOS developer responsible for implementing native iOS features, improving user experience, participating in agile squads, conducting code reviews, troubleshooting customer issues, and helping modernize backend services on AWS. Collaborates with product and UI teams and documents technical knowledge while following best practices.
Top Skills: AWSCocoapodsiOSRestfulSwiftUikitXcode
Reposted 21 Hours AgoSaved
In-Office or Remote
Boston, MA
Senior level
Senior level
Agency • Information Technology
Design, build, test, and maintain backend applications using FastAPI and SQLAlchemy. Implement database schemas, integrate front-end components, optimize for performance and scalability, debug issues, participate in code reviews, and collaborate on feature design. Maintain clean, testable code and stay current with best practices.
Top Skills: FastapiGitMySQLOraclePytestPythonSQLSqlalchemy
11 Days AgoSaved
In-Office or Remote
Boston, MA
110K-270K Annually
Senior level
110K-270K Annually
Senior level
Big Data • Cloud • Healthtech • Software • Big Data Analytics
Build and own features for a new AI-driven enterprise SaaS platform for life sciences. Design, develop, deploy, and support production Python services, collaborate on technical design, drive scalability, mentor engineers, and define engineering best practices with AI-assisted workflows.
Top Skills: AICloudFastapiGitPydanticPythonSaaS
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2 Days AgoSaved
Remote or Hybrid
Boston, MA
170K-200K Annually
Senior level
170K-200K Annually
Senior level
eCommerce • Information Technology • Machine Learning • Marketing Tech • Database • Analytics • Big Data Analytics
Design and implement scalable backend and distributed systems for a marketing intelligence platform. Build near-real-time ingestion and processing, scale an incrementality/experimentation product, integrate AI-powered workflows, improve data ingestion/exports and connection-state systems, and contribute frontend components to deliver end-to-end product experiences.
Top Skills: AIAPIsData ProcessingDistributed SystemsMachine LearningMicroservicesPythonRbacReactReal-Time Data IngestionTypescript
4 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Edtech • Consulting
Senior backend engineer on an education-focused technology consulting team. Own complex backend systems end-to-end: estimate scope, build and support production Python services, design REST/GraphQL APIs, work with cloud and Docker, use relational databases, maintain strong automated tests and Git workflows, and represent technical work to clients. Role values mentorship, ownership, and mission-driven work.
Top Skills: Ai ToolsAWSDockerFastapiGitGraphQLPostgresPythonRest
Reposted 4 Days AgoSaved
Remote
Boston, MA
165K-215K Annually
Senior level
165K-215K Annually
Senior level
Legal Tech • Software
Design and implement durable, fault-tolerant AI orchestration and backend systems using Temporal and agentic ReAct patterns. Deliver features end-to-end with testing, CI/CD, monitoring, and observability; mentor engineers and collaborate with cross-functional teams to translate legal workflows into reliable AI-powered features.
Top Skills: Async/AwaitClaude (Llm)Event-Driven ArchitectureFastapiGitlab Ci/CdMessage QueuesNew Relic ApmOctopus DeployPlaywrightPydantic V2Pydantic-AiPytestPython 3.12+ReactStructlogSyrupyTemporal
Reposted 4 Days AgoSaved
Remote
Boston, MA
200K-225K Annually
Senior level
200K-225K Annually
Senior level
Artificial Intelligence • eCommerce • Software
Design and build backend systems and APIs for AI-driven products, ensuring scalability, reliability, and integration of ML models while collaborating with engineering and product teams.
Top Skills: APIsAWSAzureDockerGCPKubernetesLlmsMachine LearningNoSQLPythonSQL
Reposted 14 Days AgoSaved
In-Office
Boston, MA
115K-195K Annually
Senior level
115K-195K Annually
Senior level
Information Technology • Software • Database
Maintain and improve the LangChain Python package, enhance documentation, assist users, and build example applications.
Top Skills: Python
Reposted 6 Days AgoSaved
Remote
Boston, MA
100K-200K Annually
Senior level
100K-200K Annually
Senior level
Artificial Intelligence • HR Tech • Information Technology • Software
As a Founding Staff Software Engineer, you will lead the design and development of robust backend systems and APIs, optimize large-scale data workflows, and mentor a growing engineering team.
Top Skills: AWSCeleryFastapiOpensearchPostgresPythonRedisTemporal
Reposted 18 Days AgoSaved
In-Office
Boston, MA
153K-229K Annually
Senior level
153K-229K Annually
Senior level
Healthtech
Lead the technical direction for integrating algorithms on the Prism Mapping platform, focusing on real-time signal pipelines and optimization strategies. Collaborate with teams to ensure robust clinical performance and timely delivery of new capabilities.
Top Skills: C++Python
Reposted 18 Days AgoSaved
In-Office
Boston, MA
125K-187K Annually
Senior level
125K-187K Annually
Senior level
Healthtech
As a Senior Software Engineer, you'll develop signals and algorithm interfaces, collaborate with developers, optimize algorithms, and mentor engineers in a regulated environment.
Top Skills: C++Python
Reposted 8 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Logistics • Software • Transportation
Design, develop, deploy, monitor, and support APIs and system integrations (Salesforce, REST, third-party). Work directly with clients to gather requirements, troubleshoot and optimize integrations, operate solutions in AWS, collaborate with teams, and mentor junior developers.
Top Skills: Aws Api GatewayAws EcsAws LambdaAws RdsPythonRest ApiSalesforceSnsSqsTerraform
Reposted 8 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Information Technology • Logistics • Transportation • Consulting
Build and ship full‑stack features for transportation management and other client products. Design and implement APIs and UIs, collaborate with product and design, own delivery, write modular testable code, troubleshoot and iterate quickly, and mentor peers.
Top Skills: .NetC#Ci/CdDevOpsDockerElectronFastapiGraphQLJavaJavaScriptLlmsLookmlMlMongoDBMySQLNode.jsPythonReact NativeReactRestSpringTypescriptVue
Reposted 8 Days AgoSaved
Remote
Boston, MA
125K-200K Annually
Senior level
125K-200K Annually
Senior level
Software • Cybersecurity
The Forward Deployed Engineer will serve as a technical bridge between clients and engineering teams, writing custom code and integrations, while ensuring customer success with Socket's security platform through strong relationships and expert technical guidance.
Top Skills: Automation ScriptsCi/CdDevOpsPythonSastWebhook Implementations
Reposted 9 Days AgoSaved
Remote
Boston, MA
1M-2M Annually
Senior level
1M-2M Annually
Senior level
Agency • Information Technology • Software • App development
Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.
Top Skills: AWSAzureAzure PipelinesCi/CdCosmosdbDjangoDockerFastapiFlaskGenerative AiGitlab CiGCPHugging FaceJenkinsKafkaKubernetesPythonPyTorchRabbitMQRdsRest ApisServerlessTensorFlowWebsockets
Reposted 12 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Automotive
The Senior Software Engineer will build a large-scale data ingestion and classification system using web scraping, data processing, and search technologies, overseeing data extraction from various sources and developing search capabilities.
Top Skills: AirflowAWSElasticsearchKubernetesOcrOpensearchPythonScrapySpark
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