Top Senior Python Jobs in Boston, MA

Reposted 4 Days AgoSaved
Easy Apply
Hybrid
Boston, MA
Easy Apply
90K-210K Annually
Senior level
90K-210K Annually
Senior level
Aerospace • Artificial Intelligence • Computer Vision • Machine Learning • Natural Language Processing • Software • Defense
Design, develop, and maintain scalable, reliable Python applications. Participate in design and code reviews, collaborate with engineers and data scientists, adopt microservices and containerization, follow Agile practices, and support deployment and integration for DoD-focused AI/ML and simulation projects.
Top Skills: AWSAzureContainerizationDevops ToolsDockerDocker-ComposeGCPGitKanbanKubernetesMicroservice ArchitecturePysparkPythonRelational DatabasesScrumSpark
Reposted 11 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead diverse technology projects in distributed microservices and full stack systems, mentoring team members and collaborating with product managers on cloud-based solutions.
Top Skills: AWSCSSDockerGoGCPHTMLJavaJavaScriptKubernetesAzureNosql DatabasesOpen Source RdbmsPythonSQLTypescript
Reposted 12 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team to develop distributed systems using Golang and Python on Kubernetes, collaborate on AI/ML solutions, and drive technological innovation.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesNoSQLPythonRdbmsSQLTypescript
Reposted 14 Days AgoSaved
Hybrid
Boston, MA
179K-225K Annually
Senior level
179K-225K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team of developers to build technology projects using microservices and full stack systems, focusing on cloud-based solutions and mentoring team members.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesPysparkPythonSQLTypescript
Reposted 16 Days AgoSaved
Easy Apply
Remote or Hybrid
Boston, MA
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
Reposted 26 Days AgoSaved
Hybrid
Boston, MA
209K-286K Annually
Senior level
209K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a portfolio of technology projects with a team of developers to create solutions for regulatory needs, collaborating on cloud-based projects while mentoring engineers.
Top Skills: Amazon SagemakerAWSCSSDatabricksDockerGoHTMLJavaJavaScriptKubernetesLuaMcpPythonSQLTypescript
Reposted 2 Days AgoSaved
In-Office
Boston, MA
153K-229K Annually
Senior level
153K-229K Annually
Senior level
Healthtech
Lead the technical direction for integrating algorithms on the Prism Mapping platform, focusing on real-time signal pipelines and optimization strategies. Collaborate with teams to ensure robust clinical performance and timely delivery of new capabilities.
Top Skills: C++Python
2 Days AgoSaved
In-Office or Remote
Boston, MA
50-55 Hourly
Senior level
50-55 Hourly
Senior level
Agency • Information Technology • Professional Services • Software
Develop and maintain AWS cloud-native applications and backend services using Python. Design scalable architectures, APIs, event-driven applications, and system integrations with Lambda, Step Functions, Kafka, Terraform, and CloudWatch. Troubleshoot complex cloud issues, support migration and modernization, and contribute to technical architecture decisions. This is a hands-on senior developer role requiring regular coding, strong system design, and backend development expertise, with Java-to-Python/AWS experience preferred.
Top Skills: Amazon CloudwatchApache KafkaApi DevelopmentAWSAws LambdaAws Step FunctionsInfrastructure As CodeJavaPythonTerraform
Reposted 2 Days AgoSaved
In-Office
Boston, MA
125K-187K Annually
Senior level
125K-187K Annually
Senior level
Healthtech
As a Senior Software Engineer, you'll develop signals and algorithm interfaces, collaborate with developers, optimize algorithms, and mentor engineers in a regulated environment.
Top Skills: C++Python
Reposted 7 Days AgoSaved
In-Office
Boston, MA
107K-216K Annually
Senior level
107K-216K Annually
Senior level
Fintech
The Principal Python Backend Engineer will design and build high-performance backend systems for AI/ML services, focus on clean code, maintainability, and automation, while leading teams through a collaborative and innovative approach.
Top Skills: AWSCi/CdDockerKubernetesPython
Reposted 2 Days AgoSaved
Remote
Boston, MA
1M-2M Annually
Senior level
1M-2M Annually
Senior level
Agency • Information Technology • Software • App development
Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.
Top Skills: AWSAzureAzure PipelinesCi/CdCosmosdbDjangoDockerFastapiFlaskGenerative AiGitlab CiGCPHugging FaceJenkinsKafkaKubernetesPythonPyTorchRabbitMQRdsRest ApisServerlessTensorFlowWebsockets
Reposted 2 Days AgoSaved
Remote or Hybrid
Boston, MA
Senior level
Senior level
Digital Media • Social Media • Software • Design
Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.
Top Skills: Python
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Reposted 2 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Lead Software Engineer responsible for designing, developing, testing, and maintaining a distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements, implement cloud and big-data solutions (Spark/Hadoop), and ensure program standards and reliable delivery.
Top Skills: SparkAWSDroolsHadoopIbm OdmJavaLinuxPythonShell ScriptingSnowflakeSQLVisual StudioVs Code
Reposted 2 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Develop, test, and maintain a complex distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements. Work with distributed workloads (Spark/Hadoop), SQL/Snowflake, AWS, shell scripting, and job scheduling/process automation. Support delivery under Agile/SAFe practices and ensure alignment with program standards.
Top Skills: AWSBash/Shell ScriptingDroolsHadoopJavaLinux (Cli)OdmPythonSnowflakeSparkSQLVs Code
Reposted 2 Days AgoSaved
Remote
Boston, MA
4K-5K Hourly
Senior level
4K-5K Hourly
Senior level
Travel
Lead development of Python-based web applications using Django and FastAPI, architect scalable solutions, and establish technical standards while mentoring developers and optimizing infrastructure.
Top Skills: Ai Coding AssistantsAWSDjangoFastapiGitPostgresPythonRailway
Reposted 2 Days AgoSaved
In-Office or Remote
Boston, MA
Senior level
Senior level
Cloud • Software
The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.
Top Skills: CC++DockerGoKubernetesLinuxNoSQLPythonRustSQL
Reposted 2 Days AgoSaved
In-Office or Remote
Boston, MA
Senior level
Senior level
Digital Media
Develop and enhance features for EnrollWise, contribute to a scalable software architecture, review code, collaborate on design and technical feasibility, and maintain software quality.
Top Skills: ApolloAWSDjangoDjango OrmGraphQLNextjsPythonReact
Reposted 3 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Healthtech • Software
Lead backend development on the scheduling platform modernization, contribute across products, write APIs, and drive AI-accelerated software development workflows.
Top Skills: .NetAgent OrchestrationAi-Assisted DevelopmentLlm ToolingPython
Reposted 3 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Healthtech • Software
Lead backend development on the scheduling platform modernization. Contribute across Python and .NET ecosystems, write APIs, review code, and support AI-accelerated development workflows while collaborating in a remote team environment.
Top Skills: .NetAi-Assisted Development WorkflowsClaude CodeLlm ToolingMulti-Agent SystemsPython
Reposted 12 Days AgoSaved
In-Office
Boston, MA
60K-80K Annually
Senior level
60K-80K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Develop Python-based solutions performing SQL/CRUD operations, file extraction/transformation/generation (CSV, XML, JSON, PDF), and email integration. Work in an onsite/offshore model, collaborate with teams, communicate clearly, and perform under pressure for contract assignments.
Top Skills: CsvDatabaseEmail IntegrationJSONPdfPythonSQLXML
3 Days AgoSaved
Remote
Boston, MA
80K-100K Annually
Senior level
80K-100K Annually
Senior level
Blockchain • Software • Financial Services • Cryptocurrency
Design, build, and scale distributed backend services supporting hundreds of thousands of users. Develop efficient Golang and Python code, optimize infrastructure, make architectural decisions, conduct code reviews, and collaborate with frontend and mobile engineers. The role also involves technical planning, platform innovation, and contributing to product evolution in an autonomous startup environment.
Top Skills: AWSBlockchainCassandraClickhouseDappsDockerGoGrafanaKubernetesMongoDBPostgresPrometheusPythonSentrySmart ContractsTimescaledb
Reposted 4 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Software
Lead the design and development of scalable Python backend services and APIs on AWS, mentor engineers, and manage PostgreSQL databases in a healthcare technology environment.
Top Skills: Api GatewayAWSBitbucketDockerGitJIRAKubernetesLambdaOauth 2PostgresPythonRest ApiSlackTeams
4 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Information Technology • Software • Consulting
Build and maintain full-stack wealth management platform features using Python and Angular or React. Design service-oriented architectures and REST/SOAP APIs, work with relational databases and ORMs, contribute to AWS or Azure cloud architecture, and deploy using container technologies. Collaborate in Agile/Scrum ceremonies, participate in code reviews and demos, and work independently with distributed teams.
Top Skills: AngularAWSAzureConfluenceDjangoDockerEcsFlaskJavaScriptJIRAJSONKubernetesMySQLOracleOrmPostgresPythonReactRestSoapSQLSQL Server
Reposted 4 Days AgoSaved
Remote
Boston, MA
156K-205K Annually
Senior level
156K-205K Annually
Senior level
eCommerce
Lead design, build, and operate scalable backend services and carrier integrations. Provide technical leadership, mentor engineers, drive architecture and best practices, write and test code, troubleshoot production incidents, and improve monitoring and reliability while collaborating with product and cross-functional teams.
Top Skills: AWSConfluenceDistributed SystemsEnd-To-End TestingIntegration TestingJIRAMicroservicesMonitoring/Observability/AlertingPythonRelational DatabasesRest ApisSQLUnit TestingVersion Control
Reposted 5 Days AgoSaved
Remote
Boston, MA
388K-619K Annually
Senior level
388K-619K Annually
Senior level
News + Entertainment
Build and maintain internal Python platform libraries and tooling to improve developer experience. Drive runtime, dependency, testing, delivery, monitoring, and performance optimization for Python services (including GPU-enabled workloads). Collaborate cross-functionally to define an opinionated SDLC, support on-call rotations, and balance modern practices with risk-aware change. Enable scalable, low-latency distributed systems and provide AI/ML-facing platform capabilities.
Top Skills: CudaDynamoFastapiFlaskLitserveOnnxPythonPytorch (Torch.Compile)Ray ServeTensorrtTritonVllm
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