Top Senior Python Jobs in Boston, MA

Reposted 7 Days AgoSaved
Hybrid
Boston, MA
209K-286K Annually
Senior level
209K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a portfolio of technology projects with a team of developers to create solutions for regulatory needs, collaborating on cloud-based projects while mentoring engineers.
Top Skills: Amazon SagemakerAWSCSSDatabricksDockerGoHTMLJavaJavaScriptKubernetesLuaMcpPythonSQLTypescript
Reposted 11 Days AgoSaved
Easy Apply
Hybrid
Boston, MA
Easy Apply
90K-210K Annually
Senior level
90K-210K Annually
Senior level
Aerospace • Artificial Intelligence • Computer Vision • Machine Learning • Natural Language Processing • Software • Defense
Design, develop, and maintain scalable, reliable Python applications. Participate in design and code reviews, collaborate with engineers and data scientists, adopt microservices and containerization, follow Agile practices, and support deployment and integration for DoD-focused AI/ML and simulation projects.
Top Skills: AWSAzureContainerizationDevops ToolsDockerDocker-ComposeGCPGitKanbanKubernetesMicroservice ArchitecturePysparkPythonRelational DatabasesScrumSpark
Reposted 18 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead diverse technology projects in distributed microservices and full stack systems, mentoring team members and collaborating with product managers on cloud-based solutions.
Top Skills: AWSCSSDockerGoGCPHTMLJavaJavaScriptKubernetesAzureNosql DatabasesOpen Source RdbmsPythonSQLTypescript
Reposted 19 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team to develop distributed systems using Golang and Python on Kubernetes, collaborate on AI/ML solutions, and drive technological innovation.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesNoSQLPythonRdbmsSQLTypescript
Reposted 4 Days AgoSaved
In-Office
Boston, MA
Senior level
Senior level
Software
Build and maintain Python backend applications and data pipelines integrating machine learning with user data. Ensure reliable, accurate processing across MySQL, PostgreSQL, Snowflake, and Databricks environments. Optimize SEO content delivery and page rankings, monitor pipeline quality, and collaborate with SEO specialists and data scientists. The role also requires production-quality coding, unit testing, CI/CD practices, and maintainable software development.
Top Skills: AirflowAWSCi/CdDatabricksHTMLMongoDBMongodb AtlasMySQLPostgresPythonReactSnowflakeUnit Testing FrameworksVersion Control
Reposted 4 Days AgoSaved
In-Office or Remote
Boston, MA
110K-270K Annually
Senior level
110K-270K Annually
Senior level
Big Data • Cloud • Healthtech • Software • Big Data Analytics
Build and own features for a new AI-driven enterprise SaaS platform for life sciences. Design, develop, deploy, and support production Python services, collaborate on technical design, drive scalability, mentor engineers, and define engineering best practices with AI-assisted workflows.
Top Skills: AICloudFastapiGitPydanticPythonSaaS
Reposted 5 Days AgoSaved
In-Office
Boston, MA
107K-216K Annually
Senior level
107K-216K Annually
Senior level
Fintech
The Principal Python Backend Engineer will design and build high-performance backend systems for AI/ML services, focus on clean code, maintainability, and automation, while leading teams through a collaborative and innovative approach.
Top Skills: AWSCi/CdDockerKubernetesPython
Reposted 23 Days AgoSaved
Easy Apply
Remote or Hybrid
Boston, MA
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
6 Days AgoSaved
In-Office
Boston, MA
100K-160K Annually
Senior level
100K-160K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Design, develop, troubleshoot, and enhance enterprise Python applications, data-intensive services, and automation platforms. Build secure, reliable distributed systems; optimize large-scale data processing; create reporting and visualization tools; and support production operations through debugging, incident response, and monitoring. Contribute to architecture, code reviews, Agile and CI/CD practices, testing, reliability improvements, and mentoring while collaborating with product, data, infrastructure, and business teams.
Top Skills: Ci/CdMicrosoft Sql ServerOraclePostgresPythonSybase
Reposted 9 Days AgoSaved
In-Office
Boston, MA
153K-229K Annually
Senior level
153K-229K Annually
Senior level
Healthtech
Lead the technical direction for integrating algorithms on the Prism Mapping platform, focusing on real-time signal pipelines and optimization strategies. Collaborate with teams to ensure robust clinical performance and timely delivery of new capabilities.
Top Skills: C++Python
Reposted 9 Days AgoSaved
In-Office
Boston, MA
125K-187K Annually
Senior level
125K-187K Annually
Senior level
Healthtech
As a Senior Software Engineer, you'll develop signals and algorithm interfaces, collaborate with developers, optimize algorithms, and mentor engineers in a regulated environment.
Top Skills: C++Python
Reposted 4 Days AgoSaved
Remote
Boston, MA
156K-205K Annually
Senior level
156K-205K Annually
Senior level
eCommerce
Lead design, build, and operate scalable backend services and carrier integrations. Provide technical leadership, mentor engineers, drive architecture and best practices, write and test code, troubleshoot production incidents, and improve monitoring and reliability while collaborating with product and cross-functional teams.
Top Skills: AWSConfluenceDistributed SystemsEnd-To-End TestingIntegration TestingJIRAMicroservicesMonitoring/Observability/AlertingPythonRelational DatabasesRest ApisSQLUnit TestingVersion Control
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4 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Big Data • Internet of Things • Mobile • Other
Design and operate customer-facing networking APIs, Python orchestration control planes, and automation that configures routers across global points of presence. Build resource allocation, job queues, retries, rollback, reconciliation, BGP, WireGuard, GRE, NAT, firewall, DNS, cloud interconnect, and Envoy xDS integrations. Own production monitoring, incident response, billing synchronization, API compatibility, and network configuration drift detection across application and infrastructure layers.
Top Skills: AiohttpAiopgAlembicAnsibleAnsible-RunnerAsyncioAsyncsshAWSAzureBashBgpBlackBugsnagDockerEnvoyEquinix FabricEquinix MetalFrrGCPGithub ActionsGoGo-Control-PlaneGreHashicorp VaultJinja2LinuxMypyNatNetaddrNetboxNetfilterNetmikoNetplanOciOpenapi 3PostgresPrometheusPynetboxPytestPythonRabbitMQRedoclyRuffSqlalchemyTcpdumpTelegrafUnboundUvloopVrfVyosWireguardXds
5 Days AgoSaved
Remote
Boston, MA
100-200 Hourly
Senior level
100-200 Hourly
Senior level
HR Tech • Other • Professional Services
Evaluate AI coding-agent interactions for usefulness, correctness, engineering judgment, reasoning quality, and user trust. Provide rigorous, opinionated feedback distinguishing response quality levels and help define best practices for tools such as OpenAI Codex, Claude Code, and Cursor. This contract role requires strong software engineering expertise, familiarity with AI-assisted development workflows, and the ability to assess code and explanations without deeply reviewing or executing every line.
Top Skills: Claude CodeCursorJavaScriptOpenai CodexPythonTypescript
5 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Big Data • Blockchain • Software • Business Intelligence • App development • Big Data Analytics • Automation
Design, build, and maintain scalable full-stack web applications using React, Python, Node.js, and C#. Develop cloud-native AWS solutions with event-driven and serverless architectures, manage relational and NoSQL data stores, write automated tests, maintain infrastructure as code, and contribute to CI/CD pipelines. Collaborate with cross-functional engineering teams on architecture, security, performance, and end-to-end feature delivery in an agile environment.
Top Skills: Aws Application Load BalancerAws CloudfrontAws DynamodbAws EcsAws EventbridgeAws LambdaAws SqsC#Ci/CdEvent-Driven ArchitectureGitlab Ci/CdInfrastructure As CodeJestNode.jsNosql DatabasesPlaywrightPostgresPythonReactRelational DatabasesServerless ArchitectureSQLTerraform
5 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Big Data • Blockchain • Software • Business Intelligence • App development • Big Data Analytics • Automation
Develop and maintain end-to-end applications using Python, Node.js, C#, and React. Build scalable backend services, frontend features, APIs, cloud-native AWS solutions, automated tests, infrastructure as code, and CI/CD pipelines. Collaborate with cross-functional engineering teams in an agile, remote environment while contributing to architecture and reliable product delivery for US clients.
Top Skills: Aws Application Load BalancerAws CloudfrontAws DynamodbAws EcsAws EventbridgeAws LambdaAws SqsC#Gitlab Ci/CdJestNode.jsPlaywrightPostgresPythonReactSQLTerraform
6 Days AgoSaved
In-Office or Remote
Boston, MA
42K-147K Annually
Senior level
42K-147K Annually
Senior level
Agency • Information Technology
Design, develop, test, and maintain scalable Python applications, backend services, REST APIs, microservices, and integrations. Work with databases, asynchronous processing, cloud platforms, containers, CI/CD, security, observability, and distributed systems. Troubleshoot production issues, optimize performance, create automated tests, participate in code reviews and architecture decisions, and collaborate with product, DevOps, QA, and engineering teams.
Top Skills: AsyncioAWSAzureCi/CdDevOpsDjangoDockerDynamoDBFastapiFlaskGCPGenerative AiGitKafkaKubernetesLangchainLanggraphLlmsMicroservicesMongoDBMySQLOpenai SdkOraclePostgresPytestPythonPython 3.XRabbitMQRedisRest ApisSQLSqsUnittest
6 Days AgoSaved
Remote
Boston, MA
200K-225K Annually
Senior level
200K-225K Annually
Senior level
Artificial Intelligence • Computer Vision • Machine Learning • Analytics
Develop open source SDKs, enterprise APIs, UIs, and backend systems supporting large-scale computer vision datasets. Build scalable, maintainable, performant, and well-tested software for unstructured data and AI workflows. Contribute to enterprise deployments across customer clouds and on-premises environments, while improving tooling, automation, engineering practices, and open source community initiatives in a remote-first team.
Top Skills: DocumentdbElasticsearchMongoDBPythonTypescript
Reposted 7 Days AgoSaved
Remote or Hybrid
Boston, MA
Senior level
Senior level
Digital Media • Social Media • Software • Design
Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.
Top Skills: Python
Reposted 7 Days AgoSaved
Remote
Boston, MA
1M-2M Annually
Senior level
1M-2M Annually
Senior level
Agency • Information Technology • Software • App development
Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.
Top Skills: AWSAzureAzure PipelinesCi/CdCosmosdbDjangoDockerFastapiFlaskGenerative AiGitlab CiGCPHugging FaceJenkinsKafkaKubernetesPythonPyTorchRabbitMQRdsRest ApisServerlessTensorFlowWebsockets
Reposted 7 Days AgoSaved
In-Office or Remote
Boston, MA
135K-155K Annually
Senior level
135K-155K Annually
Senior level
Machine Learning • Other
The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.
Top Skills: AWSCi/CdDockerPostgresPostgresql/PostgisPythonTerraform
Reposted 7 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Information Technology • Professional Services • Software
The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.
Top Skills: CSSDjangoDockerFastapiFlaskGitGnu/LinuxHTMLJavaScriptMongoDBMySQLNode.jsOraclePostgresPythonReactSvnVue
Reposted 9 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Lead Software Engineer responsible for designing, developing, testing, and maintaining a distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements, implement cloud and big-data solutions (Spark/Hadoop), and ensure program standards and reliable delivery.
Top Skills: SparkAWSDroolsHadoopIbm OdmJavaLinuxPythonShell ScriptingSnowflakeSQLVisual StudioVs Code
Reposted 9 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Develop, test, and maintain a complex distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements. Work with distributed workloads (Spark/Hadoop), SQL/Snowflake, AWS, shell scripting, and job scheduling/process automation. Support delivery under Agile/SAFe practices and ensure alignment with program standards.
Top Skills: AWSBash/Shell ScriptingDroolsHadoopJavaLinux (Cli)OdmPythonSnowflakeSparkSQLVs Code
Reposted 9 Days AgoSaved
Remote
Boston, MA
4K-5K Hourly
Senior level
4K-5K Hourly
Senior level
Travel
Lead development of Python-based web applications using Django and FastAPI, architect scalable solutions, and establish technical standards while mentoring developers and optimizing infrastructure.
Top Skills: Ai Coding AssistantsAWSDjangoFastapiGitPostgresPythonRailway
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