Top Senior Python Jobs in Boston, MA

Reposted 6 Days AgoSaved
Hybrid
Boston, MA
209K-286K Annually
Senior level
209K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a portfolio of technology projects with a team of developers to create solutions for regulatory needs, collaborating on cloud-based projects while mentoring engineers.
Top Skills: Amazon SagemakerAWSCSSDatabricksDockerGoHTMLJavaJavaScriptKubernetesLuaMcpPythonSQLTypescript
Reposted 17 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead diverse technology projects in distributed microservices and full stack systems, mentoring team members and collaborating with product managers on cloud-based solutions.
Top Skills: AWSCSSDockerGoGCPHTMLJavaJavaScriptKubernetesAzureNosql DatabasesOpen Source RdbmsPythonSQLTypescript
Reposted 2 Days AgoSaved
Remote
Boston, MA
1M-2M Annually
Senior level
1M-2M Annually
Senior level
Agency • Information Technology • Software • App development
Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.
Top Skills: AWSAzureAzure PipelinesCi/CdCosmosdbDjangoDockerFastapiFlaskGenerative AiGitlab CiGCPHugging FaceJenkinsKafkaKubernetesPythonPyTorchRabbitMQRdsRest ApisServerlessTensorFlowWebsockets
Reposted 18 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team to develop distributed systems using Golang and Python on Kubernetes, collaborate on AI/ML solutions, and drive technological innovation.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesNoSQLPythonRdbmsSQLTypescript
Reposted 20 Days AgoSaved
Hybrid
Boston, MA
179K-225K Annually
Senior level
179K-225K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team of developers to build technology projects using microservices and full stack systems, focusing on cloud-based solutions and mentoring team members.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesPysparkPythonSQLTypescript
Reposted 6 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Information Technology • Professional Services • Software
The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.
Top Skills: CSSDjangoDockerFastapiFlaskGitGnu/LinuxHTMLJavaScriptMongoDBMySQLNode.jsOraclePostgresPythonReactSvnVue
Reposted 8 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Logistics • Software • Transportation
The Principal Python Engineer will design, build, and maintain backend services and APIs, focusing on system reliability and engineering quality. The role involves working with databases, applying DevOps practices, and leveraging AI for development efficiency.
Top Skills: DockerFastapiKubernetesPostgresPulumiPythonTemporalVue
Reposted 8 Days AgoSaved
In-Office or Remote
Boston, MA
Senior level
Senior level
Cloud • Software
The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.
Top Skills: CC++DockerGoKubernetesLinuxNoSQLPythonRustSQL
18 Days AgoSaved
In-Office
Boston, MA
60K-80K Annually
Senior level
60K-80K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Develop Python-based solutions performing SQL/CRUD operations, file extraction/transformation/generation (CSV, XML, JSON, PDF), and email integration. Work in an onsite/offshore model, collaborate with teams, communicate clearly, and perform under pressure for contract assignments.
Top Skills: CsvDatabaseEmail IntegrationJSONPdfPythonSQLXML
YesterdaySaved
In-Office
Boston, MA
100K-150K Annually
Senior level
100K-150K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Design, build, and maintain enterprise-grade Python applications and data-processing systems. Deliver secure, high-performance code, optimize large-scale data workflows, produce architecture artifacts, support production incidents, and mentor engineers while collaborating with product, data, and infrastructure teams.
Top Skills: Ci/CdMs Sql ServerOraclePostgresPythonSQLSybase
Reposted 2 Days AgoSaved
In-Office
Boston, MA
115K-195K Annually
Senior level
115K-195K Annually
Senior level
Information Technology • Software • Database
Maintain and improve the LangChain Python package, enhance documentation, assist users, and build example applications.
Top Skills: Python
Reposted 22 Days AgoSaved
Easy Apply
Remote or Hybrid
Boston, MA
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
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Reposted 4 Days AgoSaved
In-Office
Boston, MA
120K-228K Annually
Senior level
120K-228K Annually
Senior level
Artificial Intelligence • Consumer Web • Digital Media • Software
Design, implement, and scale event-driven, distributed backend systems in Python on AWS to process and enrich large-scale document and media datasets. Lead technical projects, mentor engineers, integrate ML/LLM components, optimize performance, maintain observability, and collaborate with Data Science, ML Engineering, and Product to deliver reliable high-throughput content processing services.
Top Skills: AirflowAWSCloudwatchDatabricksDatadogEcsElasticacheLambdaLlmMachine LearningPythonScalaSnsSparkSqsTerraform
Reposted 6 Days AgoSaved
In-Office
Boston, MA
153K-229K Annually
Senior level
153K-229K Annually
Senior level
Healthtech
Lead the technical direction for integrating algorithms on the Prism Mapping platform, focusing on real-time signal pipelines and optimization strategies. Collaborate with teams to ensure robust clinical performance and timely delivery of new capabilities.
Top Skills: C++Python
Reposted 6 Days AgoSaved
In-Office
Boston, MA
125K-187K Annually
Senior level
125K-187K Annually
Senior level
Healthtech
As a Senior Software Engineer, you'll develop signals and algorithm interfaces, collaborate with developers, optimize algorithms, and mentor engineers in a regulated environment.
Top Skills: C++Python
58 Minutes AgoSaved
Remote
Boston, MA
Senior level
Senior level
Cloud • Information Technology
Lead development of a document-centric web interface integrating Vertex AI Search. Build React frontends and Python backends, implement document processing, vector search/RAG pipelines, optimize performance and scalability, write tests, and collaborate with cloud and architecture teams to deliver an enterprise-grade AI platform.
Top Skills: Agentic AiDjangoElasticsearchFastapiFlaskGoogle Cloud PlatformPineconePythonRagReactReact HooksRestful ApisState ManagementVector SearchVertex Ai Search
Reposted 13 Hours AgoSaved
Remote
Boston, MA
Senior level
Senior level
Automotive
The Senior Software Engineer will build a large-scale data ingestion and classification system using web scraping, data processing, and search technologies, overseeing data extraction from various sources and developing search capabilities.
Top Skills: AirflowAWSElasticsearchKubernetesOcrOpensearchPythonScrapySpark
Reposted 13 Hours AgoSaved
Remote
Boston, MA
Senior level
Senior level
Travel
As a Staff Software Engineer, you’ll lead the design and reliability of Duetto's data lakehouse, evolving data systems using Python and AWS, ensuring data quality, and implementing AI-driven solutions.
Top Skills: AirflowAWSDatadogDockerGithub ActionsGlueIcebergPysparkPythonSagemakerSentrySumo LogicTerraform
Reposted 13 Hours AgoSaved
Remote
Boston, MA
141K-208K Annually
Senior level
141K-208K Annually
Senior level
Database • Analytics
Own and evolve ClickHouse's Python connector and SDKs; build and maintain integrations with orchestration and transformation tools; design AI/LLM integration patterns (RAG, embeddings, feature stores); engage with open-source community; collaborate with Product and Cloud teams to prioritize and ship production-grade data integrations.
Top Skills: Apache AirflowApache FlinkSparkAsyncClickhouseDagsterDbtFivetranKafka ConnectLangchainLlamaindexMultiprocessingN8NNumpyPandasPrefectPydanticPythonSQLSqlmeshThreading
Reposted 2 Days AgoSaved
Remote
Boston, MA
139K-203K Annually
Senior level
139K-203K Annually
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Marketing Tech • Software • Biotech • Design
Develop and maintain backend solutions, ensuring performance, security, and regulatory compliance, while collaborating in cross-functional teams.
Top Skills: AWSFastapiPython
Reposted 12 Days AgoSaved
In-Office
Boston, MA
107K-216K Annually
Senior level
107K-216K Annually
Senior level
Fintech
The Principal Python Backend Engineer will design and build high-performance backend systems for AI/ML services, focus on clean code, maintainability, and automation, while leading teams through a collaborative and innovative approach.
Top Skills: AWSCi/CdDockerKubernetesPython
Reposted 4 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Information Technology • Consulting
Design and build applications using Python, manage component design, optimize performance, and collaborate with clients on innovative products.
Top Skills: Ai ToolsCi/CdGitGoKubernetesPythonReact
Reposted 6 Days AgoSaved
In-Office or Remote
Boston, MA
135K-155K Annually
Senior level
135K-155K Annually
Senior level
Machine Learning • Other
The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.
Top Skills: AWSCi/CdDockerPostgresPostgresql/PostgisPythonTerraform
7 Days AgoSaved
Remote or Hybrid
Boston, MA
Senior level
Senior level
Aerospace • Artificial Intelligence • Defense • Manufacturing
Develop and maintain flight and ground station software for satellite communications subsystems. Design and validate constrained-hardware platform applications, improve test coverage and documentation, contribute to architecture and peer reviews, and provide expert support to satellite operations.
Top Skills: BashCi/CdDockerGitGitlabGnu/LinuxHTTPKubernetesPythonTcp/Ip
Senior level
Gaming • Software
As a Senior Full Stack Software Engineer, you will design and maintain the core platform for sports betting, developing APIs and frontend features, optimizing performance, and ensuring compliance while mentoring junior engineers.
Top Skills: Next.JsPythonReactTypescript
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