Top Senior Python Jobs in Boston, MA

Reposted YesterdaySaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead diverse technology projects in distributed microservices and full stack systems, mentoring team members and collaborating with product managers on cloud-based solutions.
Top Skills: AWSCSSDockerGoGCPHTMLJavaJavaScriptKubernetesAzureNosql DatabasesOpen Source RdbmsPythonSQLTypescript
Reposted 2 Days AgoSaved
Hybrid
Boston, MA
230K-286K Annually
Senior level
230K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team to develop distributed systems using Golang and Python on Kubernetes, collaborate on AI/ML solutions, and drive technological innovation.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesNoSQLPythonRdbmsSQLTypescript
Reposted 4 Days AgoSaved
Hybrid
Boston, MA
179K-225K Annually
Senior level
179K-225K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a team of developers to build technology projects using microservices and full stack systems, focusing on cloud-based solutions and mentoring team members.
Top Skills: AWSAzureCSSDockerGCPGoHTMLJavaJavaScriptKubernetesPysparkPythonSQLTypescript
2 Days AgoSaved
In-Office
Boston, MA
60K-80K Annually
Senior level
60K-80K Annually
Senior level
Hardware • Information Technology • Software • Cybersecurity
Senior Python developer responsible for backend development and DB CRUD using Python, performing file ETL (CSV, XML, JSON, PDF), integrating email workflows, and collaborating in an onsite/offshore model. Requires strong communication and ability to work under pressure.
Top Skills: CsvDatabasesEmail Integration (Smtp)JSONPdfPythonSQLXML
2 Days AgoSaved
In-Office
Boston, MA
60K-80K Annually
Senior level
60K-80K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Develop Python-based solutions performing SQL/CRUD operations, file extraction/transformation/generation (CSV, XML, JSON, PDF), and email integration. Work in an onsite/offshore model, collaborate with teams, communicate clearly, and perform under pressure for contract assignments.
Top Skills: CsvDatabaseEmail IntegrationJSONPdfPythonSQLXML
Reposted 6 Days AgoSaved
Easy Apply
Remote or Hybrid
Boston, MA
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
Reposted 16 Days AgoSaved
Hybrid
Boston, MA
209K-286K Annually
Senior level
209K-286K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead a portfolio of technology projects with a team of developers to create solutions for regulatory needs, collaborating on cloud-based projects while mentoring engineers.
Top Skills: Amazon SagemakerAWSCSSDatabricksDockerGoHTMLJavaJavaScriptKubernetesLuaMcpPythonSQLTypescript
2 Days AgoSaved
In-Office or Remote
Boston, MA
83K-150K Annually
Senior level
83K-150K Annually
Senior level
Information Technology
Senior Full Stack Python Engineer responsible for full SDLC: design, implement, test, deploy, and support cloud-native applications. Collaborate with architects and clients, perform code reviews, mentor junior engineers, create technical documentation and user stories, and participate in Agile ceremonies. Leverage AWS services and AI tools to modernize applications and improve delivery.
Top Skills: Ai ToolsAmazon S3AWSAws LambdaGenerative AiPythonReact
Reposted 11 Days AgoSaved
Remote
Boston, MA
1M-2M Annually
Senior level
1M-2M Annually
Senior level
Agency • Information Technology • Software • App development
Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.
Top Skills: AWSAzureAzure PipelinesCi/CdCosmosdbDjangoDockerFastapiFlaskGenerative AiGitlab CiGCPHugging FaceJenkinsKafkaKubernetesPythonPyTorchRabbitMQRdsRest ApisServerlessTensorFlowWebsockets
Reposted 16 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Information Technology • Professional Services • Software
The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.
Top Skills: CSSDjangoDockerFastapiFlaskGitGnu/LinuxHTMLJavaScriptMongoDBMySQLNode.jsOraclePostgresPythonReactSvnVue
Reposted 18 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Logistics • Software • Transportation
The Principal Python Engineer will design, build, and maintain backend services and APIs, focusing on system reliability and engineering quality. The role involves working with databases, applying DevOps practices, and leveraging AI for development efficiency.
Top Skills: DockerFastapiKubernetesPostgresPulumiPythonTemporalVue
Reposted 18 Days AgoSaved
In-Office or Remote
Boston, MA
Senior level
Senior level
Cloud • Software
The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.
Top Skills: CC++DockerGoKubernetesLinuxNoSQLPythonRustSQL
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Reposted YesterdaySaved
Remote
Boston, MA
200K-225K Annually
Senior level
200K-225K Annually
Senior level
Artificial Intelligence • eCommerce • Software
Design and build backend systems and APIs for AI-driven products, ensuring scalability, reliability, and integration of ML models while collaborating with engineering and product teams.
Top Skills: APIsAWSAzureDockerGCPKubernetesLlmsMachine LearningNoSQLPythonSQL
Reposted YesterdaySaved
Remote
Boston, MA
165K-215K Annually
Senior level
165K-215K Annually
Senior level
Legal Tech • Software
Design and implement durable, fault-tolerant AI orchestration and backend systems using Temporal and agentic ReAct patterns. Deliver features end-to-end with testing, CI/CD, monitoring, and observability; mentor engineers and collaborate with cross-functional teams to translate legal workflows into reliable AI-powered features.
Top Skills: Async/AwaitClaude (Llm)Event-Driven ArchitectureFastapiGitlab Ci/CdMessage QueuesNew Relic ApmOctopus DeployPlaywrightPydantic V2Pydantic-AiPytestPython 3.12+ReactStructlogSyrupyTemporal
Reposted 12 Days AgoSaved
In-Office
Boston, MA
115K-195K Annually
Senior level
115K-195K Annually
Senior level
Information Technology • Software • Database
Maintain and improve the LangChain Python package, enhance documentation, assist users, and build example applications.
Top Skills: Python
Reposted 13 Days AgoSaved
In-Office
Boston, MA
153K-229K Annually
Senior level
153K-229K Annually
Senior level
Healthtech
Lead the technical direction for integrating algorithms on the Prism Mapping platform, focusing on real-time signal pipelines and optimization strategies. Collaborate with teams to ensure robust clinical performance and timely delivery of new capabilities.
Top Skills: C++Python
Reposted 13 Days AgoSaved
In-Office
Boston, MA
125K-187K Annually
Senior level
125K-187K Annually
Senior level
Healthtech
As a Senior Software Engineer, you'll develop signals and algorithm interfaces, collaborate with developers, optimize algorithms, and mentor engineers in a regulated environment.
Top Skills: C++Python
Reposted 4 Days AgoSaved
Remote
Boston, MA
100K-200K Annually
Senior level
100K-200K Annually
Senior level
Artificial Intelligence • HR Tech • Information Technology • Software
As a Founding Staff Software Engineer, you will lead the design and development of robust backend systems and APIs, optimize large-scale data workflows, and mentor a growing engineering team.
Top Skills: AWSCeleryFastapiOpensearchPostgresPythonRedisTemporal
Reposted 14 Days AgoSaved
In-Office
Boston, MA
120K-228K Annually
Senior level
120K-228K Annually
Senior level
Artificial Intelligence • Consumer Web • Digital Media • Software
Design, build, and scale event-driven, distributed backend systems in Python to extract and enrich metadata at massive scale. Lead architecture, mentor engineers, integrate ML/LLM components, optimize performance, and ensure observability and reliability across AWS-based pipelines.
Top Skills: AirflowAws CloudwatchAws EcsAws ElasticacheAws LambdaAws SnsAws SqsDatabricksDatadogLlmMachine LearningPythonScalaSparkTerraform
Reposted 14 Days AgoSaved
In-Office
Boston, MA
120K-228K Annually
Senior level
120K-228K Annually
Senior level
Artificial Intelligence • Consumer Web • Digital Media • Software
Design, implement, and scale event-driven, distributed backend systems in Python on AWS to process and enrich large-scale document and media datasets. Lead technical projects, mentor engineers, integrate ML/LLM components, optimize performance, maintain observability, and collaborate with Data Science, ML Engineering, and Product to deliver reliable high-throughput content processing services.
Top Skills: AirflowAWSCloudwatchDatabricksDatadogEcsElasticacheLambdaLlmMachine LearningPythonScalaSnsSparkSqsTerraform
Reposted 6 Days AgoSaved
Remote
Boston, MA
125K-200K Annually
Senior level
125K-200K Annually
Senior level
Software • Cybersecurity
The Forward Deployed Engineer will serve as a technical bridge between clients and engineering teams, writing custom code and integrations, while ensuring customer success with Socket's security platform through strong relationships and expert technical guidance.
Top Skills: Automation ScriptsCi/CdDevOpsPythonSastWebhook Implementations
Reposted 6 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Logistics • Software • Transportation
Design, develop, deploy, monitor, and support APIs and system integrations (Salesforce, REST, third-party). Work directly with clients to gather requirements, troubleshoot and optimize integrations, operate solutions in AWS, collaborate with teams, and mentor junior developers.
Top Skills: Aws Api GatewayAws EcsAws LambdaAws RdsPythonRest ApiSalesforceSnsSqsTerraform
Reposted 6 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Information Technology • Logistics • Transportation • Consulting
Build and ship full‑stack features for transportation management and other client products. Design and implement APIs and UIs, collaborate with product and design, own delivery, write modular testable code, troubleshoot and iterate quickly, and mentor peers.
Top Skills: .NetC#Ci/CdDevOpsDockerElectronFastapiGraphQLJavaJavaScriptLlmsLookmlMlMongoDBMySQLNode.jsPythonReact NativeReactRestSpringTypescriptVue
Reposted 9 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Automotive
The Senior Software Engineer will build a large-scale data ingestion and classification system using web scraping, data processing, and search technologies, overseeing data extraction from various sources and developing search capabilities.
Top Skills: AirflowAWSElasticsearchKubernetesOcrOpensearchPythonScrapySpark
10 Days AgoSaved
Remote
Boston, MA
141K-208K Annually
Senior level
141K-208K Annually
Senior level
Database • Analytics
Own and evolve ClickHouse's Python connector and SDKs; build and maintain integrations with orchestration and transformation tools; design AI/LLM integration patterns (RAG, embeddings, feature stores); engage with open-source community; collaborate with Product and Cloud teams to prioritize and ship production-grade data integrations.
Top Skills: Apache AirflowApache FlinkSparkAsyncClickhouseDagsterDbtFivetranKafka ConnectLangchainLlamaindexMultiprocessingN8NNumpyPandasPrefectPydanticPythonSQLSqlmeshThreading
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