Top Principal Engineer Jobs in Boston, MA

The Principal Engineer will lead tech transfer and manufacturing processes for gene editing products, oversee manufacturing campaigns, and collaborate with various teams to ensure quality and regulatory compliance.

The Principal AI/ML Engineer will develop machine learning models for campaign optimization in AdTech, collaborating across engineering and product teams to enhance advertising capabilities.

As a Principal Software Engineer, you'll architect and code backend services and ML models, integrate them with Salesforce, and mentor junior engineers.

The Principal Engineer will take ownership of production-grade systems, improve customer outcomes with high-leverage features, and ensure technical quality across the stack, utilizing deep expertise in backend and AI systems.

As a Principal Software Engineer, you will solve complex technical problems, mentor teams, and lead the development of cloud-based applications for customer service solutions.

Lead the development of perception capabilities for self-driving vehicles, focusing on computer vision and deep learning to enhance product impact and safety evaluation.

As a Principal Engineer, you will lead architectural design, mentor teams, drive software development, and enhance product capabilities for PaaS offerings.

The role involves architecting a developer experience for 500+ engineers by integrating CI/CD, testing infrastructure, and AI tools to enhance productivity and reduce friction in the software delivery lifecycle.

As a Principal Developer, you will guide technical direction and architectural strategy, mentor engineers, and elevate engineering practices in the Exposure Management product area, focusing on cybersecurity solutions.

Lead engineering strategy and implementation for cGMP bioprocess and bioconjugation manufacturing. Design, optimize, and scale processes and equipment, develop PAT and automation control strategies, oversee CDMO activities, ensure regulatory compliance, and drive continuous improvement across cross-functional teams.

The Principal Engineer, Hardware will design and develop hardware architectures, collaborate with engineering teams, and mentor junior staff while ensuring project goals are met.

As a Principal Software Engineer, you will architect and develop virtualization technology for vehicle testing, mentor teams, and enhance code quality across GM products.

Design, build, train, and deploy AI models for healthcare applications, collaborate with product management, and integrate solutions.

The Principal Software Engineer will set technical direction, own cross-team initiatives, evolve platform architecture, and lead experimentation efforts while mentoring others in the Personal Loans team.

Lead the design of Xsolla's identity platform, develop Golang microservices for user management, and implement security protocols for compliance.

The Principal Perception Hardware Engineer leads the design and execution of camera-based sensing systems and optical subsystems, ensuring integration of vision technologies and delivering high-quality hardware solutions while collaborating with cross-functional teams and mentoring junior members.

The Principal Engineer will lead enterprise scalability efforts, driving architectural changes, optimizing systems, and integrating AI for improved operational performance across multi-tenant SaaS platforms.

The Principal Software Engineer will tackle platform-level challenges, assist team members, write secure and scalable code, and develop features for cloud storage solutions.

The Principal Engineer - AI will lead AI/ML strategy, design solutions, mentor teams, and collaborate across functions to enhance environmental and social risk management through innovative applications of AI.

The Principal Software Engineer will lead AI automation efforts at Coinbase, designing AI-driven systems, mentoring teams, and solving complex AI challenges to improve operations and developer productivity.

Lead architecture and development of high-performance, scalable cloud firewall services. Design, implement, and test low-latency L3-L7 security systems, build CI/CD and test infrastructure, coordinate across product, QA, and support, and ensure reliability, scalability, and observability for enterprise customers.

Lead systems engineering for infusion medical devices: develop and manage system/subsystem requirements, ensure regulatory compliance (DHF, ISO, IEC, FDA), support risk management, V&V, and cross-functional design activities, investigate root causes, and document system assessments throughout the product lifecycle.

Lead the technical direction of PaaS at DigitalOcean by architecting and implementing robust cloud-native services while mentoring engineers and ensuring system reliability.

This role leads the ML Acceleration team, focusing on enhancing ML model training efficiency and team management, while driving technical strategy and collaboration.

The Principal Packaging Engineer will oversee lab operations, manage packaging development projects, ensure compliance with standards, and provide strategic direction to teams.