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Top Principal Engineer Jobs in Boston, MA
Biotech
Lead engineering strategy and implementation for cGMP bioprocess and bioconjugation manufacturing. Design, optimize, and scale processes and equipment, develop PAT and automation control strategies, oversee CDMO activities, ensure regulatory compliance, and drive continuous improvement across cross-functional teams.
Top Skills:
Advanced Process AnalyticsAutomationBioconjugationBiologics Downstream PurificationCdmoCgmpContinuous ManufacturingControl SystemsLeanManufacturing SkidsPatProcess CharacterizationProcess Control Strategy (Pcs)Process ModelingReal-Time MonitoringScale-Down Model Qualification (Sdmq)Six Sigma
Cloud • Information Technology
The Principal Cloud Support Engineer at Wasabi leads technical support, mentors engineers, resolves complex issues, and advises enterprise clients, focusing on cloud storage solutions.
Top Skills:
Aws S3Cloud StorageDnsHTTPLinuxTcp/IpTls
Machine Learning • Security • Software • Analytics • Defense
The Principal Radar Systems Engineer leads radar system development, collaborates with multi-disciplinary teams, and ensures effective solutions to customer needs while applying systems engineering principles.
Top Skills:
CC++MatlabPythonRadar SystemsRf SensingSysml
Appliances • Manufacturing
The Principal Engineer for Customer Quality acts as the key customer contact for quality issues, addressing complaints, and driving continuous improvement. This role requires collaboration with multiple teams to establish quality standards and facilitate customer audits, while managing quality performance and supporting product lifecycle decisions.
Top Skills:
Iatf16949Iso13485Iso9000MS OfficeVda
Artificial Intelligence • Cloud • Software • Infrastructure as a Service (IaaS)
As a Security Engineer, safeguard Runpod's GPU cloud platform, conduct security assessments, implement fixes, and foster a security-first culture with development teams.
Top Skills:
CDockerEdrGoKubernetesLinuxPythonSIEMWaf
Gaming
Lead the design of Xsolla's identity platform, develop Golang microservices for user management, and implement security protocols for compliance.
Top Skills:
AWSAzureGCPGoHashicorp VaultKubernetesOauth2OidcSAMLScim
Healthtech • Software
The Principal Engineer will lead the design and development of ML infrastructure, mentor engineers, and provide strategic technical leadership for AI-powered applications in healthcare.
Top Skills:
AWSBigtableGCPGenaiKubernetesMlopsPostgresRedisSpannerVitess
Big Data • Information Technology • Software • Database • Analytics • Infrastructure as a Service (IaaS) • Big Data Analytics
The Principal Engineer will lead AI-driven productivity initiatives, develop a strategy for integrating AI in engineering workflows, and improve collaboration across teams. Responsibilities include executing projects, ensuring code quality, and setting success metrics.
Top Skills:
AIAutomationCloudLlmSaaS
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Artificial Intelligence • Big Data • Healthtech • Machine Learning • Software • Database • Analytics
Design, build, train, and deploy AI models for healthcare applications, collaborate with product management, and integrate solutions.
Top Skills:
Aws BedrockIntersystems IrisKerasNumpyObjectscriptPandasPythonPyTorchRest ApisScikit-LearnTensorFlow
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Consumer Web • eCommerce • Marketing Tech • Retail • Software • Analytics • Generative AI
The Principal Engineer will lead enterprise scalability efforts, driving architectural changes, optimizing systems, and integrating AI for improved operational performance across multi-tenant SaaS platforms.
Top Skills:
AIBack-PressureCachingCapacity PlanningMulti-Region ReadinessPartitioningPerformance EngineeringSharding
Beauty • Robotics • Design • Appliances • Manufacturing
The Principal Electrical Systems Engineer will lead the development of prototypes, design reusable modules, and evaluate new technologies for future product platforms, collaborating across teams.
Top Skills:
ArduinoEmbedded SystemsPower ElectronicsRaspberry PiSensorsWireless Communication
Reposted 6 Days AgoSaved
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Cloud • Healthtech • Professional Services • Software • Pharmaceutical
The Director, Enterprise AI will spearhead AI initiatives across the organization, oversee deployment strategies, and drive innovation.
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Automotive • Big Data • Insurance • Software • Transportation
The Principal ML Engineer at Agero will develop and productionize a Dispatch System using ML models, optimize decision-making processes, and lead a team to improve operational performance.
Top Skills:
AirflowAWSAzureGCPPythonPyTorchSagemakerSQLXgboost
Hardware • Semiconductor
The Principal Engineer - Process will support manufacturing and development of the Chip Scale Atomic Clock, focusing on process optimization, materials analysis, and lean manufacturing methodologies.
Top Skills:
BomsErpLean ManufacturingPlmSix SigmaStatistical Methods
Artificial Intelligence • Cloud • Information Technology • Consulting
The Principal Engineer, Hardware will design and develop hardware architectures, collaborate with engineering teams, and mentor junior staff while ensuring project goals are met.
Top Skills:
Bus Protocol AnalyzersCadence System CaptureComputer EngineeringElectrical EngineeringFpgaHigh-Speed CircuitryLinuxOscilloscopesPcbPerlPythonTclUnix
Information Technology
The Principal Consulting Engineer will design, deploy, and optimize VMware Cloud Foundation automation solutions, ensuring they meet customer requirements while leading engagements and providing technical expertise.
Top Skills:
Active DirectoryAnsibleCi/CdGitGitlabPowershellPythonServicenowTerraformVmware Cloud Foundation
Information Technology
The Principal Consulting Engineer designs, deploys, and optimizes private cloud infrastructures, ensuring solutions meet customer approval and providing technical leadership.
Top Skills:
AnsiblePythonSddc ManagerTerraformVcf 9.0Vmware Cloud Foundation
7 Days AgoSaved
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Cloud • Information Technology • Security • Software • Cybersecurity
As a Principal Specialist Sales Engineer for Data Security, you will partner with sales teams, deliver technical presentations, gather customer requirements, and lead product evaluations for SLED and Healthcare customers.
Top Skills:
AIData ProtectionData SecurityNetworking SolutionsSaas TechnologiesSecurity SolutionsWeb-Related Technologies
AdTech • Artificial Intelligence • Marketing Tech • Software • Analytics
The Principal DevOps Engineer will lead the design and operation of CI/CD pipelines, platform reliability, and compliance for software deployment, while influencing DevOps practices and simplifying operational management across teams.
Top Skills:
Apache KafkaAWSDockerDynamoDBGitlab Ci/CdGrafanaKubernetesPrometheusSqsTerraform
Consumer Web • Coupons • Healthtech • Social Impact • Pharmaceutical
Lead the machine learning strategy, design scalable ML systems, drive MLOps, mentor engineers, and comply with AI governance.
Top Skills:
AirflowAWSAzureGCPGoPythonPyTorchTensorFlowXgboost
Artificial Intelligence • Fintech • Machine Learning • Social Impact • Software
Lead the architectural design and development of a new consumer credit product, focusing on backend systems, distributed services, and integrating AI tools. Mentor team members and influence product direction through engineering insights.
Top Skills:
APIsAvroC#DatabasesJavaKafkaKinesisKotlinProtobufPythonRubySqs
Biotech
The role involves developing applications and tools for data visualization in clinical trials, managing projects, and ensuring compliance with data standards. Responsibilities include programming in R, creating dashboards, and integrating data across clinical systems.
Top Skills:
Azure DevopsData.TableDplyrGgplot2GitKnitrLeafletPlotlyPurrrRRcolorbrewerStringrTidyr
Artificial Intelligence • Food • Machine Learning • Software
The Principal Engineer leads architectural decisions, influences engineering standards, and designs high-complexity systems using ASP.NET, while mentoring teams and integrating AI solutions.
Top Skills:
.NetAIAsp.NetBlazorEf CoreMlPostgres
18 Days AgoSaved
Artificial Intelligence • Fintech • Insurance • Marketing Tech • Software • Analytics
The Principal Front-Office Engineer will lead the design and implementation of AI-driven solutions in investment strategies, collaborating with analysts to enhance toolsets and reporting systems.
Top Skills:
CvxpyDashGitNumpyPandasPlotlyPythonScikit-LearnScipySQL
Cloud • Fintech • Food • Information Technology • Software • Hospitality
The Principal Product Analytics Engineer leads the design and architecture of Toast's product analytics ecosystem, ensuring reliable and scalable data for analysis across various platforms. This role involves creating data frameworks, implementing quality controls, and collaborating with cross-functional teams to support data-driven product development and AI insights.
Top Skills:
AirflowAmazon S3AmplitudeChatgptClaudeCursorDbtHexMcpPythonSigmaSnowflakeSQL
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