Top Senior Systems Engineer Jobs in Boston, MA

Designs system architectures, requirements, interfaces, and performance metrics for robotaxi systems spanning autonomy, remote operations, fleet orchestration, mapping, and customer-facing software. Evaluates system performance through data pipelines, simulation, verification, and validation campaigns; collaborates across engineering and operations teams; documents complex workflows; and supports safety-focused autonomous vehicle deployment.

Design, secure, administer, and improve on-premises, cloud, and hybrid infrastructure. Manage servers, networks, operating systems, virtualization, firewalls, endpoints, and monitoring tools. Strengthen security controls, investigate incidents with a third-party SOC, manage vulnerabilities and risks, maintain documentation, and lead infrastructure and security projects including upgrades, migrations, automation, and tool deployments.

Build and operate identity, endpoint, SaaS, and IT automation infrastructure. Develop API integrations, AI-powered workflows, identity lifecycle automation, device management, security controls, and audit-readiness processes. Manage macOS and iOS fleets, strengthen access security, and own complex technical projects from design through operation. Collaborate with IT Operations, Security, Revenue Operations, and business teams to deliver reliable, scalable systems using code, infrastructure as code, testing, monitoring, and documentation.

Design and commission vacuum-system machinery for Stack Forging thermal manufacturing, bringing products from laboratory development into mass production. Responsibilities include machine and subsystem design, CAD and documentation, thermal and structural analysis, vacuum calculations, FEA, tolerance stack-up analysis, root-cause investigation, equipment reliability and automation improvements, prototype testing, requirements development, design reviews, and vendor management. The role requires four onsite days per week in Burlington, Massachusetts.

Designs, implements, secures, and supports enterprise IT systems across a multi-site manufacturing environment. Owns Tier 3 incident resolution, hybrid and multi-cloud infrastructure, identity, endpoints, servers, networking, virtualization, and enterprise migrations. Leads modernization initiatives, supports regulated government cloud environments, develops automation and documentation, and mentors IT teams. The role requires strong expertise in Azure, AWS, Microsoft 365, Active Directory, Windows environments, hybrid architectures, and security-focused infrastructure operations.

Design and guide secure, scalable enterprise and cloud architectures (DNS, Azure, AWS, on-prem). Lead cloud migrations, implement monitoring, integrate hybrid environments, present technical briefings, and mentor staff while ensuring security and performance for a mission-focused government client.

Supports the IHS Electronic Health Records Modernization program by designing, integrating, installing, configuring, testing, and maintaining biomedical and end-user devices. Develops solutions for complex device engineering, infrastructure, security, backup, and redundancy challenges; maintains technical documentation; collaborates with cyber and implementation teams; and may lead or mentor others. The role is fully remote, requires Oracle Health experience, and may involve up to 25% travel.

Provides presales technical support for HPE Networking solutions serving Rhode Island state government and higher education accounts. Designs complex networking solutions, delivers presentations and demonstrations, supports proposals and proofs of concept, manages technical customer and partner relationships, and collaborates with territory managers to advance sales opportunities. The role requires expertise in WLAN, switching, NAC/AAA, routing, LAN/WAN technologies, consultative selling, solution design, and executive-level customer engagement.

Lead power systems engineering for utility distribution planning, DER interconnection, protection coordination, and grid integration. Perform power-flow, short-circuit, and hosting-capacity analyses; develop controls, communications, and operational technology integration solutions; guide utility technical reviews; and support battery storage and distributed generation programs. Build scalable engineering standards and processes while collaborating with utilities, technology providers, commercial teams, and project delivery.

Lead the architecture and implementation of Amplify’s design system, including reusable React components, design tokens, frontend infrastructure, documentation, and contribution workflows. Partner with Product, Design, and Engineering teams to establish standards, accessibility practices, governance, and adoption across products. Mentor engineers, guide technical decisions, improve development workflows, and explore AI-assisted development practices.

Leads architecture, engineering, security, integration, deployment, and sustainment of the Informatica Data Governance Suite in AWS GovCloud. Designs high availability, disaster recovery, Infrastructure as Code, CI/CD, monitoring, identity, security, and compliance capabilities. Coordinates Informatica, cloud, database, cybersecurity, and testing teams; supports RMF/ATO and STIG activities; reviews technical artifacts; manages risks; and transfers operational knowledge to government personnel.

Build and operate Node.js and TypeScript backend services using durable workflows and AI-assisted development. Define service patterns, orchestrate migrations, maintain MCP and AI workflow tooling, and improve observability through metrics, alerts, dashboards, and tracing. Handle production incidents, contribute targeted frontend changes in React and Angular, and collaborate on architecture and code reviews in a fully remote environment.

Lead research and development of autonomous internal network and Active Directory attack capabilities for the NodeZero platform. Build production-grade Python systems, exploit vulnerabilities and misconfigurations, extend graph-based attack models, validate complex attack scenarios, and maintain safe, scalable offensive tooling. Mentor engineers, conduct code reviews, shape coverage priorities, document technical decisions, and collaborate with product, engineering, and customer-facing teams.

Provides system-level technical leadership for commercial medical devices across design changes, lifecycle management, reliability, risk management, requirements, integration, verification, and complex issue resolution. Partners with multidisciplinary teams across engineering, quality, manufacturing, regulatory, service, and operations. Requires regulated-industry engineering experience, with preferred medical device post-commercialization expertise and knowledge of systems engineering, reliability methods, design controls, and medical device standards.

Provides system-level technical leadership for commercial medical devices across commercialization and sustaining engineering. Leads requirements, architecture, risk management, reliability assessments, integration, verification testing, and complex product issue investigations. Partners with engineering, quality, manufacturing, regulatory, service, and operations teams to maintain safe, reliable, compliant products. Mentors engineers and guides systems engineering practices, design controls, and industry standards.

Leads technical pre-sales activities for enterprise storage solutions, partnering with sales teams, customers, and channel partners. Translates business requirements into storage and cloud architectures, manages evaluations and benchmarks, delivers technical presentations, supports RFPs and competitive positioning, and drives technical wins. The role requires deep expertise in storage architectures, Linux, networking, distributed systems, cloud-native technologies, containers, and enterprise applications.

Leads system integration, verification, validation, defect analysis, and remediation for medical device products. Translates user needs and system requirements into traceable test cases, executes system-level testing, analyzes risks and results, supports DFMEA and risk-control verification, and ensures compliance with medical device standards and regulations. Collaborates with cross-functional teams on issue resolution, product safety, design reviews, and readiness milestones. Some domestic and international travel may be required.

Leads reliability and maintainability activities across unmanned aircraft product lifecycles. Develops R&M architectures, reliability predictions, FMEA/FMECA, fault trees, reliability block diagrams, FRACAS processes, test plans, and reliability growth programs. Conducts failure investigations, corrective actions, maintenance analyses, and R&M risk mitigation. Presents analyses and compliance status to customers during milestone and design reviews, while ensuring adherence to defense reliability standards.

Lead systems engineering for advanced audio platforms across embedded, cloud, mobile, and AI/ML domains. Define architecture and requirements, perform trade studies and risk analysis, ensure traceability and verification, drive platform reuse, influence hardware/software decisions, and partner cross-functionally to deliver consumer and automotive audio products from concept through launch.

Own and scale Cribl’s corporate IT systems, including Okta identity, AWS infrastructure, endpoint management, ServiceNow, SaaS integrations, automation, and AI tool governance. Lead lifecycle workflows, security baselines, compliance reporting, incident escalation, and on-call operations while partnering with Security, Enterprise Applications, Finance, Compliance, and People teams.

Leads the design, implementation, and optimization of enterprise infrastructure, cloud services, identity, endpoint management, and monitoring systems. Drives automation, security hardening, incident response, root-cause analysis, migrations, disaster recovery, and operational improvements. Mentors junior administrators, maintains technical documentation, manages vendor escalations, and supports cross-functional technology initiatives. Requires strong infrastructure, cloud, security, troubleshooting, scripting, observability, and IT service management expertise.

Owns end-to-end system architecture for robotic manipulation platforms. Defines requirements, functional allocations, interfaces, roadmaps, and architecture documentation; leads cross-domain requirements decomposition, trade studies, integration, verification, validation, and acceptance planning. Drives technical decisions, manages architectural risks, establishes systems engineering governance, and mentors engineering teams through design and architecture reviews.

Serve as the senior LabVantage LIMS expert for Moderna’s Digital Laboratory Systems organization. Lead continuous improvements, support cross-functional projects, and design integrations with MES, SAP, LIMS, and eQMS. Provide level 2/3 application support, including upgrades, patching, deployments, maintenance, and version control. Help shape the integrated digital laboratory systems strategy, manage risks, support demand planning, and develop business cases for system changes in a GxP and GMP environment.

Supports the Air Force E-7 program through systems engineering, acquisition documentation, requirements analysis, technical reviews, risk and configuration management, trade studies, system validation, and lifecycle engineering. Develops requirements and certification approaches, evaluates system concepts and proposals, supports verification and validation, and prepares engineering plans, assessments, and technical documentation. The role is hybrid at Hanscom Air Force Base and requires active Secret clearance and U.S. citizenship.

Lead complex presales engagements for Boomi’s API Management solutions across North America. Design API-first strategies, governance models, security policies, developer portals, and enterprise architectures. Advise executive stakeholders on digital ecosystems and business value, lead proofs of concept and RFI/RFP responses, and demonstrate integration between API Management and iPaaS capabilities. The role requires deep expertise in API lifecycle management, gateways, identity and security frameworks, cloud platforms, microservices, service mesh, and event-driven architectures.