Top Senior Systems Engineer Jobs in Boston, MA

Lead systems engineering for a next-generation autonomous UAS, including system architecture, requirements decomposition, behavior modeling, avionics and autonomy integration, safety analysis, trade studies, flight testing, and performance validation. Collaborate with hardware, software, propulsion, manufacturing, flight operations, DoD stakeholders, and government agencies to develop a mission-ready aircraft from clean sheet through first flight and deployment.

Lead and contribute to the design, integration, deployment, and sustainment of mission-focused systems. Translate stakeholder needs into technical requirements, architectures, interface definitions, deployment patterns, and operational processes. Partner with software engineers and data scientists to integrate applications, data pipelines, infrastructure, and external systems. Support testing, verification, troubleshooting, operational readiness, documentation, and reliability improvements for secure, scalable, data-intensive systems.

Leads systems engineering for wearable hardware programs, including requirements management, system architecture, interface definitions, verification and validation, technical documentation, design reviews, risk resolution, and cross-functional integration across electrical, mechanical, firmware, signal processing, manufacturing, and product teams. Provides technical leadership and mentorship while collaborating with partners, suppliers, and manufacturers through up to 15% domestic and international travel.

Develop and lead mechanical and ocean engineering solutions for uncrewed undersea systems, including vehicles, buoys, pressure vessels, hydrodynamic structures, and sensor subsystems. Responsibilities include modeling and simulation, prototyping, fabrication, integration, testing, peer reviews, technical documentation, and collaboration across mechanical, electrical, acoustic, software, and systems teams. The role supports advanced defense and ISR research involving fielded undersea systems.

Leads architecture and systems engineering for vacuum SEMI platforms in semiconductor automation. Responsibilities include cross-functional project leadership, technology integration, customer engagement, technical innovation, mentoring engineers, and presenting to management. Requires advanced expertise in vacuum systems and semiconductor automation design, with international travel potentially expected.

Defines, integrates, and evaluates advanced technology prototypes and proofs of concept for surgical robotics and digital orthopaedic applications. Develops system architectures, requirements, interfaces, demonstration plans, feasibility studies, and performance evaluations. Collaborates with engineering, clinical, quality, regulatory, and external partners; investigates anomalies, performs root-cause analysis, supports testing, cadaveric studies, surgeon engagement, and technical demonstrations. Applies risk-based engineering, statistical analysis, and medical-device principles to guide technology maturation.

Lead systems engineering for advanced audio platforms across embedded, cloud, mobile, and AI/ML domains. Define architecture and requirements, perform trade studies and risk analysis, ensure traceability and verification, drive platform reuse, influence hardware/software decisions, and partner cross-functionally to deliver consumer and automotive audio products from concept through launch.

Lead design and implementation of data architecture and scalable storage solutions, drive AI/GenAI thought leadership, oversee data governance and security, translate business requirements into technical plans, implement FastAPI endpoints, enhance LLMs through prompt engineering, and manage cross-functional teams to deliver advanced data and AI solutions.

Develop and optimize AI and machine learning algorithms, models, and scalable Python systems. Transform raw data into actionable insights, apply machine learning libraries and NLP techniques, improve data quality, and deliver automation solutions for clients. The role also involves complex data analysis, stakeholder collaboration, client relationship management, and navigating ambiguous business challenges.

Serve as the senior LabVantage LIMS expert for Moderna’s Digital Laboratory Systems organization. Lead continuous improvements, support cross-functional projects, and design integrations with MES, SAP, LIMS, and eQMS. Provide level 2/3 application support, including upgrades, patching, deployments, maintenance, and version control. Help shape the integrated digital laboratory systems strategy, manage risks, support demand planning, and develop business cases for system changes in a GxP and GMP environment.

Lead complex presales engagements for Boomi’s API Management solutions across North America. Design API-first strategies, governance models, security policies, developer portals, and enterprise architectures. Advise executive stakeholders on digital ecosystems and business value, lead proofs of concept and RFI/RFP responses, and demonstrate integration between API Management and iPaaS capabilities. The role requires deep expertise in API lifecycle management, gateways, identity and security frameworks, cloud platforms, microservices, service mesh, and event-driven architectures.

Own the design, administration, reliability, security, and roadmap of enterprise identity, endpoint, and SaaS systems. Lead SSO, SCIM, device management, integrations, automation, and AI-assisted workflow projects end to end. Translate ambiguous business needs into scalable solutions, troubleshoot complex incidents, maintain audit-ready controls, evaluate vendors, document systems, mentor engineers, and participate in an after-hours on-call rotation.

Leads complex audio product development from concept through launch, coordinating multidisciplinary internal teams, external partners, and contract manufacturers. Designs and integrates acoustics, DSP, algorithms, firmware, software, hardware, and SoC elements. Drives engineering plans, feasibility assessments, risk resolution, technical deliverables, regulatory compliance, and product-cost targets. Develops and validates audio algorithms and system-level processing architectures using C, MATLAB, Simulink, and real-time DSP techniques.

Defines and verifies the operating domain for autonomous robotaxi deployments, collaborates with autonomy, mapping, infrastructure, and operations teams, and develops AI-powered tools to assess expansion opportunities. The role includes analyzing system performance, validating map releases against constraints, documenting tools, supporting testing and coverage analysis, and contributing to the safety case for commercial launch. Requires strong Python, SQL, visualization, version control, software development, data analysis, and communication skills.

Support U.S. Air Force weapon system acquisition and sustainment programs through engineering analyses, acquisition planning, milestone preparation, technical evaluations, design reviews, testing, integration, deficiency resolution, and airworthiness documentation. Collaborate with government program offices, contractors, and stakeholders on engineering change proposals, requirements, certification activities, and program reviews.

Design, develop, optimize, and test real-time acoustic signal-processing algorithms for distributed undersea systems. Implement embedded software across low-SWAP, ARM, DSP, and server-class hardware while meeting stringent performance requirements. Collaborate on hardware integration and validation using C/C++, Python, MATLAB, Linux, Git, containers, and Jira. The role requires embedded systems, signal processing, hardware-interface, optimization, and debugging expertise, plus an active security clearance and eligibility for special access programs.

Own OT security engineering for laboratory instruments, automation, and building systems. Translate OT security architecture into controls (segmentation, identity, PAM, PKI), build detection and response, validate vendor integrations, run vulnerability and lifecycle management, and mentor engineers while partnering with SOC, OT engineering, and lab operations.

Integrate and test advanced RF hardware and software systems in laboratory, software-in-the-loop, and field environments. Develop hardware test sets, test software, plans, and procedures; execute testing against system requirements; document results and metrics; support technical reviews and briefings. Collaborate with development and systems engineering teams to integrate verification artifacts into Digital Engineering and MBSE workflows.

Build and operate secure, scalable multi-cloud infrastructure across AWS, GCP, and networking platforms. Develop self-service tooling, infrastructure-as-code defaults, cloud guardrails, and standardized platform patterns. Lead cross-team infrastructure initiatives, technical investigations, and operational improvements while partnering with security, compute, routing, and other infrastructure teams.

Design, develop, and maintain scalable backend services, APIs, integrations, data pipelines, automation, and workflows for internal business systems. Partner with cross-functional stakeholders to translate business needs into technical solutions. Ensure system reliability, performance, security, and scalability while contributing to technical strategy, code reviews, engineering best practices, mentorship, and process improvement.

Design and develop scalable, highly available software systems for NinjaOne’s IT Operations platform. Build Java and Kotlin applications, implement enterprise design patterns, optimize systems serving millions of endpoints, and contribute production code. Responsibilities include REST service development, relational database work, client-server messaging, caching, scalability improvements, and quality testing. The role collaborates with engineers to deliver reliable cloud services supporting worldwide operations.

Develop and execute systems engineering lifecycle assignments for complex defense, space, electronic, and biotechnology systems. Build and integrate multidisciplinary models, conduct simulation-based analysis and trade-space exploration, assess technical risks, recommend design modifications, and support system-level decision-making. Lead small teams, collaborate with customers and stakeholders, mentor engineers, and apply digital engineering, modeling, machine learning, and data-driven methods across the product lifecycle.

Design, develop, and deploy advanced software systems using systems engineering and MBSE. Derive and document requirements from incomplete software implementations, create SysML models in Cameo, perform capability gap analyses, and maintain traceability across the systems lifecycle. Collaborate with domain experts and software teams on mission planning, ISR management, and decision-support applications. The role requires an active DoD Top Secret clearance with SCI eligibility and supports a hybrid work environment.

Designs, implements, administers, and supports critical Linux infrastructure and enterprise systems. Diagnoses system issues, develops remediation plans, supports application infrastructure, and contributes to compliance activities. Builds automation, deployment pipelines, and infrastructure-as-code solutions using Linux, cloud, Kubernetes, GitOps, and configuration-management tools. Partners with engineering, security, and operations teams to improve reliability, scalability, security, and deployment efficiency while mentoring junior engineers.

Develop and document complex autonomy-system architectures using MBSE, SysML, DoDAF, and service-oriented patterns. Establish modeling standards, ontologies, traceability, and toolchain workflows; integrate systems models and verification activities into CI/CD pipelines. Facilitate architecture sessions, support distributed implementations and multi-system integration, and collaborate with software, platform, and integration teams in DevOps environments. Communicate architectural concepts and maintain alignment across technical baselines and program milestones.