Top Senior Systems Engineer Jobs in Boston, MA

Leads system integration, verification, validation, defect analysis, and remediation for medical device products. Translates user needs and system requirements into traceable test cases, executes system-level testing, analyzes risks and results, supports DFMEA and risk-control verification, and ensures compliance with medical device standards and regulations. Collaborates with cross-functional teams on issue resolution, product safety, design reviews, and readiness milestones. Some domestic and international travel may be required.

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Own and scale Cribl’s corporate IT systems, including Okta identity, AWS infrastructure, endpoint management, ServiceNow, SaaS integrations, automation, and AI tool governance. Lead lifecycle workflows, security baselines, compliance reporting, incident escalation, and on-call operations while partnering with Security, Enterprise Applications, Finance, Compliance, and People teams.

Lead systems engineering for advanced audio platforms across embedded, cloud, mobile, and AI/ML domains. Define architecture and requirements, perform trade studies and risk analysis, ensure traceability and verification, drive platform reuse, influence hardware/software decisions, and partner cross-functionally to deliver consumer and automotive audio products from concept through launch.

Leads the design, implementation, and optimization of enterprise infrastructure, cloud services, identity, endpoint management, and monitoring systems. Drives automation, security hardening, incident response, root-cause analysis, migrations, disaster recovery, and operational improvements. Mentors junior administrators, maintains technical documentation, manages vendor escalations, and supports cross-functional technology initiatives. Requires strong infrastructure, cloud, security, troubleshooting, scripting, observability, and IT service management expertise.

Designs and delivers EPMS, electrical telemetry, and industrial controls solutions for Microsoft AI datacenters. Responsibilities include defining instrumentation and communications requirements, configuring EPMS hardware and networks, developing system integrations, testing and commissioning technologies, troubleshooting complex electrical and controls issues, producing technical documentation, and coordinating with multidisciplinary engineering, vendor, commissioning, and deployment teams.

Lead design and implementation of data architecture and scalable storage solutions, drive AI/GenAI thought leadership, oversee data governance and security, translate business requirements into technical plans, implement FastAPI endpoints, enhance LLMs through prompt engineering, and manage cross-functional teams to deliver advanced data and AI solutions.

Owns end-to-end system architecture for robotic manipulation platforms. Defines requirements, functional allocations, interfaces, roadmaps, and architecture documentation; leads cross-domain requirements decomposition, trade studies, integration, verification, validation, and acceptance planning. Drives technical decisions, manages architectural risks, establishes systems engineering governance, and mentors engineering teams through design and architecture reviews.

Design, implement, and ensure quality of systems stack, tools, and SDK integration for AI frameworks. Collaborate with hardware and ML teams, apply engineering principles, write low-level/high-performance code, define architecture, estimate scope, and drive coding standards.

Serve as the senior LabVantage LIMS expert for Moderna’s Digital Laboratory Systems organization. Lead continuous improvements, support cross-functional projects, and design integrations with MES, SAP, LIMS, and eQMS. Provide level 2/3 application support, including upgrades, patching, deployments, maintenance, and version control. Help shape the integrated digital laboratory systems strategy, manage risks, support demand planning, and develop business cases for system changes in a GxP and GMP environment.

Supports the Air Force E-7 program through systems engineering, acquisition documentation, requirements analysis, technical reviews, risk and configuration management, trade studies, system validation, and lifecycle engineering. Develops requirements and certification approaches, evaluates system concepts and proposals, supports verification and validation, and prepares engineering plans, assessments, and technical documentation. The role is hybrid at Hanscom Air Force Base and requires active Secret clearance and U.S. citizenship.

Lead complex presales engagements for Boomi’s API Management solutions across North America. Design API-first strategies, governance models, security policies, developer portals, and enterprise architectures. Advise executive stakeholders on digital ecosystems and business value, lead proofs of concept and RFI/RFP responses, and demonstrate integration between API Management and iPaaS capabilities. The role requires deep expertise in API lifecycle management, gateways, identity and security frameworks, cloud platforms, microservices, service mesh, and event-driven architectures.

Develop and govern scalable NetSuite customizations and integrations using SuiteScript, automated testing, and AI-assisted development. Partner with Finance, Supply Chain, Logistics, and business users to translate requirements into durable solutions. Establish coding, testing, documentation, configuration, change-management, and AI-use standards while supporting integrations with Workato, billing platforms, payment processors, 3PL partners, and enterprise APIs.

Own the design, administration, reliability, security, and roadmap of enterprise identity, endpoint, and SaaS systems. Lead SSO, SCIM, device management, integrations, automation, and AI-assisted workflow projects end to end. Translate ambiguous business needs into scalable solutions, troubleshoot complex incidents, maintain audit-ready controls, evaluate vendors, document systems, mentor engineers, and participate in an after-hours on-call rotation.

Provides senior systems engineering support for a Foreign Military Sales Japan program within the Air Force ISR/SOF portfolio. Responsibilities include portfolio reviews, requirements and architecture analysis, technical baseline and configuration management, system validation and testing, trade studies, risk management, technical reviews, acquisition and sustainment support, and engineering documentation. The role is based at Hanscom Air Force Base and supports systems development, integration, deployment, fielding, and operations oversight.

Lead design, implementation, and maintenance of system architectures across applications, infrastructure, and cloud platforms for federal IT modernization. Provide technical leadership, ensure performance, reliability, and integration, produce documentation, and collaborate with DevOps, security, and stakeholders within Agile teams.

Architect, deploy, and operate highly available multi-cloud infrastructure across AWS and Azure. Manage Kubernetes, Linux systems, databases, caching platforms, CI/CD pipelines, infrastructure as code, observability, security, incident response, and performance optimization. The role also requires automation with Python and Bash, comprehensive documentation, client collaboration, and participation in a 24/7 on-call rotation.

Provides advanced remote IT support, systems administration, infrastructure troubleshooting, and technical escalation across client environments. Administers Microsoft 365, Windows Server, identity systems, Azure, networking, virtualization, endpoint management, and cybersecurity technologies. Mentors junior engineers, resolves complex tickets, maintains documentation and change controls, supports infrastructure initiatives, and evaluates emerging technologies. The role requires remote availability during West Coast Pacific Time business hours and effective communication in a managed services environment.

Defines and verifies the operating domain for autonomous robotaxi deployments, collaborates with autonomy, mapping, infrastructure, and operations teams, and develops AI-powered tools to assess expansion opportunities. The role includes analyzing system performance, validating map releases against constraints, documenting tools, supporting testing and coverage analysis, and contributing to the safety case for commercial launch. Requires strong Python, SQL, visualization, version control, software development, data analysis, and communication skills.

Own the reliability, availability, performance, observability, and security of Ophelia’s GCP telehealth platform. Define SLOs, improve monitoring and incident response, expand Terraform infrastructure, strengthen CI/CD, manage disaster recovery, and address latency and Cloud Run performance. Lead on-call maturity, HIPAA/SOC 2 infrastructure controls, and reliability education for engineers. Use AI-assisted tools for automation and incident triage while partnering with technical and non-technical stakeholders.

The Senior Systems Engineer I will develop and enhance mobile applications for cardiac health solutions, collaborating with engineers and cross-functional teams to ensure compliance with standards and successful project delivery.

Own the architecture and evolution of Backblaze’s observability platform across multiple data centers. Lead metrics, logging, tracing, dashboards, infrastructure automation, Kubernetes deployments, Ceph monitoring, and network observability. Establish technical standards, capacity strategies, documentation, and operational practices while mentoring engineers and partnering across SRE, storage, network, security, and application teams. Evaluate AIOps and agentic AI solutions to improve incident detection, correlation, and response.

Support NVIDIA enterprise customers using GPU-accelerated platforms, triage hardware and AI/ML workload issues, collaborate with engineering teams, and drive cases through resolution. Develop support tools and products using AI, document customer interactions, and troubleshoot Linux-based multi-GPU systems, firmware, kernels, drivers, containers, and distributed workloads. The role also requires customer communication, technical analysis, and occasional weekend or holiday support.

Provide technical support to NVIDIA Enterprise customers by triaging and resolving issues, working with engineering on reproductions/logs, applying AI/ML and agentic AI to build support tools and products, documenting interactions and knowledge, and owning cases to resolution (occasional weekend/holiday support).

Design, develop, optimize, and test real-time acoustic signal-processing algorithms for distributed undersea systems. Implement embedded software across low-SWAP, ARM, DSP, and server-class hardware while meeting stringent performance requirements. Collaborate on hardware integration and validation using C/C++, Python, MATLAB, Linux, Git, containers, and Jira. The role requires embedded systems, signal processing, hardware-interface, optimization, and debugging expertise, plus an active security clearance and eligibility for special access programs.