Top Senior Systems Engineer Jobs in Boston, MA

Designs, implements, secures, and supports enterprise IT systems across a multi-site manufacturing environment. Owns Tier 3 incident resolution, hybrid and multi-cloud infrastructure, identity, endpoints, servers, networking, virtualization, and enterprise migrations. Leads modernization initiatives, supports regulated government cloud environments, develops automation and documentation, and mentors IT teams. The role requires strong expertise in Azure, AWS, Microsoft 365, Active Directory, Windows environments, hybrid architectures, and security-focused infrastructure operations.

Design, deploy, maintain, tune, and secure enterprise Linux environments supporting high-performance EDA compute farms. Lead infrastructure-as-code automation, configuration management, continuous deployment, and tooling development using Python, Bash, or Go. Manage LDAP/SSSD naming services, NFS and Autofs storage, virtualization, container infrastructure, registries, networking, and infrastructure telemetry. Support highly available, scalable systems and potentially integrate cloud platforms, CI/CD pipelines, EDA toolchains, and HPC clusters.

Provides presales technical support for HPE Networking solutions serving Rhode Island state government and higher education accounts. Designs complex networking solutions, delivers presentations and demonstrations, supports proposals and proofs of concept, manages technical customer and partner relationships, and collaborates with territory managers to advance sales opportunities. The role requires expertise in WLAN, switching, NAC/AAA, routing, LAN/WAN technologies, consultative selling, solution design, and executive-level customer engagement.

Build and operate Node.js and TypeScript backend services using durable workflows and AI-assisted development. Define service patterns, orchestrate migrations, maintain MCP and AI workflow tooling, and improve observability through metrics, alerts, dashboards, and tracing. Handle production incidents, contribute targeted frontend changes in React and Angular, and collaborate on architecture and code reviews in a fully remote environment.

Lead research and development of autonomous internal network and Active Directory attack capabilities for the NodeZero platform. Build production-grade Python systems, exploit vulnerabilities and misconfigurations, extend graph-based attack models, validate complex attack scenarios, and maintain safe, scalable offensive tooling. Mentor engineers, conduct code reviews, shape coverage priorities, document technical decisions, and collaborate with product, engineering, and customer-facing teams.

Provides system-level technical leadership for commercial medical devices across design changes, lifecycle management, reliability, risk management, requirements, integration, verification, and complex issue resolution. Partners with multidisciplinary teams across engineering, quality, manufacturing, regulatory, service, and operations. Requires regulated-industry engineering experience, with preferred medical device post-commercialization expertise and knowledge of systems engineering, reliability methods, design controls, and medical device standards.

Provides system-level technical leadership for commercial medical devices across commercialization and sustaining engineering. Leads requirements, architecture, risk management, reliability assessments, integration, verification testing, and complex product issue investigations. Partners with engineering, quality, manufacturing, regulatory, service, and operations teams to maintain safe, reliable, compliant products. Mentors engineers and guides systems engineering practices, design controls, and industry standards.

Serves as the senior IT escalation point for U.S. sites, resolving complex infrastructure, networking, identity, Microsoft 365, Azure, and end-user issues. Establishes security standards, manages access controls, and supports export-control compliance. Leads IT migrations, upgrades, rollouts, AI-tool integration, documentation, vendor and asset management, and technical coaching across a global IT team.

Develop and lead mechanical and ocean engineering solutions for uncrewed undersea systems, including vehicles, buoys, pressure vessels, hydrodynamic structures, and sensor subsystems. Responsibilities include modeling and simulation, prototyping, fabrication, integration, testing, peer reviews, technical documentation, and collaboration across mechanical, electrical, acoustic, software, and systems teams. The role supports advanced defense and ISR research involving fielded undersea systems.

Leads technical pre-sales activities for enterprise storage solutions, partnering with sales teams, customers, and channel partners. Translates business requirements into storage and cloud architectures, manages evaluations and benchmarks, delivers technical presentations, supports RFPs and competitive positioning, and drives technical wins. The role requires deep expertise in storage architectures, Linux, networking, distributed systems, cloud-native technologies, containers, and enterprise applications.

Leads system integration, verification, validation, defect analysis, and remediation for medical device products. Translates user needs and system requirements into traceable test cases, executes system-level testing, analyzes risks and results, supports DFMEA and risk-control verification, and ensures compliance with medical device standards and regulations. Collaborates with cross-functional teams on issue resolution, product safety, design reviews, and readiness milestones. Some domestic and international travel may be required.

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Leads reliability and maintainability activities across unmanned aircraft product lifecycles. Develops R&M architectures, reliability predictions, FMEA/FMECA, fault trees, reliability block diagrams, FRACAS processes, test plans, and reliability growth programs. Conducts failure investigations, corrective actions, maintenance analyses, and R&M risk mitigation. Presents analyses and compliance status to customers during milestone and design reviews, while ensuring adherence to defense reliability standards.

Own and scale Cribl’s corporate IT systems, including Okta identity, AWS infrastructure, endpoint management, ServiceNow, SaaS integrations, automation, and AI tool governance. Lead lifecycle workflows, security baselines, compliance reporting, incident escalation, and on-call operations while partnering with Security, Enterprise Applications, Finance, Compliance, and People teams.

Lead systems engineering for advanced audio platforms across embedded, cloud, mobile, and AI/ML domains. Define architecture and requirements, perform trade studies and risk analysis, ensure traceability and verification, drive platform reuse, influence hardware/software decisions, and partner cross-functionally to deliver consumer and automotive audio products from concept through launch.

Leads the design, implementation, and optimization of enterprise infrastructure, cloud services, identity, endpoint management, and monitoring systems. Drives automation, security hardening, incident response, root-cause analysis, migrations, disaster recovery, and operational improvements. Mentors junior administrators, maintains technical documentation, manages vendor escalations, and supports cross-functional technology initiatives. Requires strong infrastructure, cloud, security, troubleshooting, scripting, observability, and IT service management expertise.

Designs and delivers EPMS, electrical telemetry, and industrial controls solutions for Microsoft AI datacenters. Responsibilities include defining instrumentation and communications requirements, configuring EPMS hardware and networks, developing system integrations, testing and commissioning technologies, troubleshooting complex electrical and controls issues, producing technical documentation, and coordinating with multidisciplinary engineering, vendor, commissioning, and deployment teams.

Lead design and implementation of data architecture and scalable storage solutions, drive AI/GenAI thought leadership, oversee data governance and security, translate business requirements into technical plans, implement FastAPI endpoints, enhance LLMs through prompt engineering, and manage cross-functional teams to deliver advanced data and AI solutions.

Owns end-to-end system architecture for robotic manipulation platforms. Defines requirements, functional allocations, interfaces, roadmaps, and architecture documentation; leads cross-domain requirements decomposition, trade studies, integration, verification, validation, and acceptance planning. Drives technical decisions, manages architectural risks, establishes systems engineering governance, and mentors engineering teams through design and architecture reviews.

Design, implement, and ensure quality of systems stack, tools, and SDK integration for AI frameworks. Collaborate with hardware and ML teams, apply engineering principles, write low-level/high-performance code, define architecture, estimate scope, and drive coding standards.

Serve as the senior LabVantage LIMS expert for Moderna’s Digital Laboratory Systems organization. Lead continuous improvements, support cross-functional projects, and design integrations with MES, SAP, LIMS, and eQMS. Provide level 2/3 application support, including upgrades, patching, deployments, maintenance, and version control. Help shape the integrated digital laboratory systems strategy, manage risks, support demand planning, and develop business cases for system changes in a GxP and GMP environment.

Supports the Air Force E-7 program through systems engineering, acquisition documentation, requirements analysis, technical reviews, risk and configuration management, trade studies, system validation, and lifecycle engineering. Develops requirements and certification approaches, evaluates system concepts and proposals, supports verification and validation, and prepares engineering plans, assessments, and technical documentation. The role is hybrid at Hanscom Air Force Base and requires active Secret clearance and U.S. citizenship.

Lead complex presales engagements for Boomi’s API Management solutions across North America. Design API-first strategies, governance models, security policies, developer portals, and enterprise architectures. Advise executive stakeholders on digital ecosystems and business value, lead proofs of concept and RFI/RFP responses, and demonstrate integration between API Management and iPaaS capabilities. The role requires deep expertise in API lifecycle management, gateways, identity and security frameworks, cloud platforms, microservices, service mesh, and event-driven architectures.

Develop and govern scalable NetSuite customizations and integrations using SuiteScript, automated testing, and AI-assisted development. Partner with Finance, Supply Chain, Logistics, and business users to translate requirements into durable solutions. Establish coding, testing, documentation, configuration, change-management, and AI-use standards while supporting integrations with Workato, billing platforms, payment processors, 3PL partners, and enterprise APIs.

Own the design, administration, reliability, security, and roadmap of enterprise identity, endpoint, and SaaS systems. Lead SSO, SCIM, device management, integrations, automation, and AI-assisted workflow projects end to end. Translate ambiguous business needs into scalable solutions, troubleshoot complex incidents, maintain audit-ready controls, evaluate vendors, document systems, mentor engineers, and participate in an after-hours on-call rotation.