Lead architecture and engineering for global endpoint fleet across Windows and macOS. Design UEM infrastructure, automate provisioning (Autopilot, ABM), build scripts and API integrations, enforce security baselines (BitLocker, FileVault, EDR), integrate with identity providers, act as Tier 3/4 escalation, and mentor junior staff while driving roadmap and documentation.
Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
Location: Hybrid: Chicago (3 days on-site)
Position Overview:
Position Overview:
We are seeking a highly skilled and strategic Senior Endpoint Systems Engineer to join our IT team. In this role, you will serve as the primary architect and technical lead for the health, security, compliance, and lifecycle management of our global endpoint fleet.
Our environment features a balanced mix of both Windows and macOS devices. We need a senior professional with deep, dual-platform expertise who can design scalable deployment workflows, architect robust endpoint security configurations, and optimize our enterprise toolset—specifically Microsoft Intune, Jamf Pro, and Workspace ONE. As a senior member of the team, you will drive technical strategy, lead complex integration projects, and mentor junior IT staff to ensure a seamless and secure digital employee experience.
Key Responsibilities:
- Enterprise MDM Architecture: Architect, optimize, and maintain our global Unified Endpoint Management (UEM) infrastructure using Microsoft Intune, Jamf Pro, and VMware Workspace ONE.
- Strategic Fleet Engineering: Design and scale automated deployment, provisioning, and configuration management workflows for a balanced fleet of Windows 10/11 and macOS hardware.
- Modern Provisioning & Lifecycle: Standardize and evolve modern deployment frameworks utilizing Windows Autopilot, Apple Business Manager (ABM), and Automated Device Enrollment to achieve zero-touch provisioning.
- Advanced Scripting & Automation: Develop, test, and maintain robust code repositories (PowerShell for Windows; Bash/Zsh/Python for macOS) to automate complex administrative tasks, custom reporting, and API integrations.
- Security & Compliance Governance: Partner closely with the Security team to engineer and enforce endpoint security baselines (e.g., CIS Benchmarks), disk encryption protocols (BitLocker, FileVault), and EDR/antivirus agent deployments.
- Identity & Access Architecture: Lead the integration of endpoint platforms with enterprise identity and access management (IAM) systems (e.g., Entra ID, Okta), including modern single sign-on (SSO) extensions.
- Tier 3/4 Escalation & Mentorship: Act as the highest tier of technical escalation for complex endpoint, OS, and software issues. Provide mentorship, guidance, and technical training to Tier 1/2 service desk and junior systems administrators.
- Roadmapping & Documentation: Maintain a forward-looking roadmap for endpoint technologies, evaluate emerging tools, and author authoritative architectural diagrams and standard operating procedures (SOPs).
Required Skills & Qualifications:
- Experience: 5–8+ years of dedicated experience in endpoint engineering, systems administration, or infrastructure architecture within an enterprise environment.
- Dual-Platform Mastery: Comprehensive, expert-level knowledge of both Windows and macOS operating systems, system internals, and enterprise deployment methodologies.
- Enterprise Tooling Expertise: Deep hands-on engineering experience configuring and managing Microsoft Intune, Jamf Pro, and Workspace ONE at scale.
- Advanced Scripting: Strong proficiency in PowerShell and Bash/Zsh (Python or Swift is a significant plus) for advanced automation, custom scripts, and utilizing MDM APIs.
- Leadership & Communication: Proven ability to lead projects independently, collaborate across multi-functional engineering teams, and explain complex technical concepts to non-technical stakeholders.
$130,000-$145,000 annually
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Tempus AI Boston, Massachusetts, USA Office
Tempus AI Boston - Tempus Office Office
Our Boston office is a co-working space right in the heart of downtown Boston, minutes away from cobblestone streets, iconic landmarks, and waterfront views.
Similar Jobs at Tempus AI
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Analytics • Biotech • Generative AI
Lead end-to-end coordination of major IT incidents, run incident bridges, communicate status to stakeholders, drive RCA and post-incident remediation, maintain SOPs/runbooks and dashboards, and identify process improvements and automation opportunities.
Top Skills:
AgileAi ToolingExcelItsmMachine LearningSdlcServicenowSQL
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Analytics • Biotech • Generative AI
Lead product marketing and launches for oncology and life-sciences research products. Translate clinical, genomic, and AI data into compelling messaging and campaigns, produce sales and digital assets, manage MLR/compliance, run market and competitive analysis, enable commercial teams through training and events, and contribute to strategic marketing plans and conference programs to drive adoption and growth.
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Analytics • Biotech • Generative AI
Lead late-stage molecular diagnostic product development (IVD, CDx, IUO, LDT) from validation through launch. Provide scientific and strategic leadership for design controls, regulatory submissions, documentation, inspection readiness, and cross-functional coordination. Drive process standardization, issue resolution, and continuous improvement while mentoring teams and supporting partner/companion diagnostic programs.
Top Skills:
21 Cfr Part 11AutomationElnLimsSequencing-Based Assays
What you need to know about the Boston Tech Scene
Boston is a powerhouse for technology innovation thanks to world-class research universities like MIT and Harvard and a robust pipeline of venture capital investment. Host to the first telephone call and one of the first general-purpose computers ever put into use, Boston is now a hub for biotechnology, robotics and artificial intelligence — though it’s also home to several B2B software giants. So it’s no surprise that the city consistently ranks among the greatest startup ecosystems in the world.
Key Facts About Boston Tech
- Number of Tech Workers: 269,000; 9.4% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Thermo Fisher Scientific, Toast, Klaviyo, HubSpot, DraftKings
- Key Industries: Artificial intelligence, biotechnology, robotics, software, aerospace
- Funding Landscape: $15.7 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Summit Partners, Volition Capital, Bain Capital Ventures, MassVentures, Highland Capital Partners
- Research Centers and Universities: MIT, Harvard University, Boston College, Tufts University, Boston University, Northeastern University, Smithsonian Astrophysical Observatory, National Bureau of Economic Research, Broad Institute, Lowell Center for Space Science & Technology, National Emerging Infectious Diseases Laboratories
