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Supports downstream process development, manufacturing science and technology, external manufacturing, and tech transfer for monoclonal antibody products. Responsibilities include purification process development and characterization, CDMO collaboration, process monitoring database ownership, campaign readiness reviews, batch record review, change control implementation, technical presentations, and comprehensive experimental documentation.
Scholar Rock is a late-stage global biopharmaceutical company focused on developing and commercializing apitegromab for children and adults with spinal muscular atrophy (SMA) and other rare, severe, and debilitating neuromuscular diseases. As a global leader in myostatin biology, a field focused on proteins that regulate muscle mass, the Company is named for the visual resemblance of a scholar rock to protein structures. Our commitment to unlock fundamentally different treatment approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. Scholar Rock works every day to create new possibilities for patients through its highly innovative anti-myostatin program, including opportunities in additional rare neuromuscular diseases. Learn more at ScholarRock.com and follow @ScholarRock on X and on LinkedIn.
Summary of Position:
The Technical Operations Department at Scholar Rock is seeking a scientifically curious and motivated engineer in the Downstream PD & MSAT group. The successful candidate is expected to be proficient in all aspects of the purification process and be comfortable working with a multifunctional team. Experience in late-stage process development and support of external manufacturing is preferred. The selected candidate will work alongside in-house scientists to advance existing projects through the development lifecycle and transfer to CMOs.
Proficiency in AKTA operation, TFF, VRF, JMP for data trending and presentation, and design of experiment skills are key traits that will ensure success in this role.
Position Responsibilities
- Support external manufacturing of clinical and commercial assets
- Own and maintain process monitoring databases (CPV and lot history)
- Support manufacturing campaign readiness review process
- Drive batch production record review processes
- Author and drive Downstream change control implementation
- Work closely with CDMO to support tech transfer and manufacturing activities
- Technical presentation to greater TechOps team
- Support process development experiments to develop, optimize, and characterize purification processes for antibodies.
- Detailed documentation of all experimental studies
Candidate Requirements
- Educational background in Chemical Engineering, Biochemistry, Biotechnology, or related biological Sciences.
- Direct experience working with mAbs is preferred, and MSAT experience is highly desirable
- BS with 6+ years of experience
- MS with 4+ years of experience
- Ph.D. with 0-2 years of experience
Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Scholar Rock Cambridge, Massachusetts, USA Office
301 Binney St, , Cambridge, Massachusetts , United States, 02142
What you need to know about the Boston Tech Scene
Boston is a powerhouse for technology innovation thanks to world-class research universities like MIT and Harvard and a robust pipeline of venture capital investment. Host to the first telephone call and one of the first general-purpose computers ever put into use, Boston is now a hub for biotechnology, robotics and artificial intelligence — though it’s also home to several B2B software giants. So it’s no surprise that the city consistently ranks among the greatest startup ecosystems in the world.
Key Facts About Boston Tech
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