Top Remote Senior Machine Learning Engineer Jobs in Boston, MA

Build and ship production AI systems for enterprise portfolio and planning workflows. Develop anomaly and signal detection, LLM-powered insight synthesis, natural-language planning rule translation, evaluation frameworks, and MCP tools. Partner with external AI providers initially, then establish internal standards for prompt design, model selection, agent architecture, reliability, and evaluation. Collaborate closely with product, design, and domain engineering teams.

Lead AI/ML initiatives for Air Force condition-based maintenance, from predictive model development through production deployment. Architect data pipelines, develop machine learning, deep learning, NLP, and generative AI solutions, and build knowledge graph capabilities. Provide technical leadership, integrate models into applications and workflows, and monitor data quality, model performance, drift, and bias. Collaborate with engineering, cloud, software, and product teams while supporting defense aviation logistics and sustainment missions.

Design and build production-grade AI memory systems, including retrieval pipelines, storage tiers, privacy filtering, memory extraction, adaptive updates, hybrid search, and evaluation frameworks. Ship and maintain LLM-powered features, diagnose RAG and prompt failures, implement agentic workflows and tool integrations, and ensure reliable degradation and fallback strategies. Collaborate with product management to define feasible memory-system capabilities while owning production reliability.

Lead design, development, and production deployment of ML and algorithmic solutions. Own end-to-end ML systems, support distributed production reliability, communicate tradeoffs, and apply generative AI, LLM fine-tuning, RAG, and agentic techniques to product problems.

Build and operate production machine learning systems for Airbnb Payments, including LLM agents, real-time fraud detection, anomaly detection, personalization, and checkout optimization. Design, train, deploy, monitor, and continuously improve batch and streaming AI applications at global scale. Partner with product, engineering, operations, and data science teams, establish model governance and testing standards, and mentor engineers.

Designs, deploys, and operates production machine learning systems for identity resolution, scoring, deliverability, and personalization. Responsibilities include feature engineering, model training, real-time inference, graph database integration, monitoring, drift detection, retraining, low-latency APIs, and scalable data processing. The role also contributes to MLOps standards, GPU acceleration, and ML architecture while partnering with platform engineering.

Own the production lifecycle of ranking and recommendation models, including training, validation, deployment, monitoring, retraining, versioning, rollback, and retirement. Build scalable Spark-based feature and data pipelines, orchestration workflows, model hubs, observability, CI/CD, and reliability standards. Partner with data science and engineering teams to improve model quality, deployment speed, infrastructure efficiency, and operational resilience while mentoring teammates.

Lead the design, development, deployment, and operation of production-grade generative AI and LLM solutions. Build data and ML pipelines, fine-tune and evaluate models, implement RAG and prompt engineering, and establish MLOps practices on AWS. Drive use cases across insurance workflows, ensure security and responsible AI compliance, mentor engineers, and collaborate with product, engineering, security, finance, and go-to-market teams.

Lead exploration and application of large language models and generative AI for enterprise contact-center automation. Translate research into high-performing, deployable ML systems; contribute across experimentation, implementation, and deployment; collaborate with engineering and product teams; optimize performance; and help shape team strategy, innovation, and professional growth.

Lead exploration and application of large language models and generative AI, translate research into deployable ML systems, and guide strategic direction. Develop solutions across experimentation, implementation, and deployment while collaborating with engineering and product teams to optimize performance and customer outcomes in contact center automation.

Own the complete machine learning model lifecycle, from experimentation and validation through deployment, monitoring, retraining, rollback, and retirement. Build reusable training, evaluation, deployment, orchestration, and CI/CD infrastructure. Establish model promotion standards, versioning, lineage, monitoring, alerting, and incident-response processes. Partner with data scientists to preserve scientific validity, improve reliability and efficiency, support delayed-label use cases, mentor teammates, and define MLOps priorities.

Own the production lifecycle for machine learning and LLM-backed systems, including training and post-training pipelines, inference serving, model releases, monitoring, retrieval infrastructure, and cost and latency optimization. Partner with AI researchers and engineering teams to move prototypes into reliable production capabilities across customer tenants. Develop ETL and GraphQL features, enforce tenant isolation, and support deployments in regulated or customer-controlled environments.

Design, build, deploy, and optimize scalable AI and machine learning systems using large datasets. Develop predictive models, recommendation systems, personalization engines, forecasting solutions, generative AI applications, and production ML pipelines. Collaborate with data, backend, and product teams to integrate models into applications, while monitoring performance, data quality, drift, reliability, and cost. Establish best practices for evaluation, experimentation, reproducibility, and deployment, and research emerging AI technologies.

Design and deploy machine learning models for financial document processing, optimize large language models, collaborate with cross-functional teams, and guide junior peers in a fast-paced environment.

Designs, evaluates, and improves ranking and recommendation systems through experimentation, feature engineering, and production machine learning. Builds reliable data and feature pipelines, incorporates multimodal signals, manages uncertainty, calibration, and model drift, and monitors system performance. Partners cross-functionally with Engineering, Product, Business, and Analytics to deliver scalable, latency-sensitive solutions with measurable business impact.

Develop and deploy machine learning models and production software for multi-object tracking in autonomous trucks. Responsibilities include sensor fusion across camera, LiDAR, and radar; scalable PyTorch training workflows; tracking algorithm development; large-scale data analysis; C++ and Python engineering; safety and validation strategy; architecture decisions; and cross-functional collaboration. The role also provides technical leadership through design reviews, code reviews, mentoring, and engineering best practices.

The Sr. Machine Learning Engineer will develop and deploy ML solutions for healthcare, manage data pipelines, and work with large datasets to enhance healthcare delivery.

Develop and optimize large-scale advertising ranking models for CTR and CVR prediction, calibration, user representations, and sequence modeling. Own machine learning systems end to end, including data pipelines, feature engineering, training, evaluation, deployment, and maintenance. Collaborate with platform, product, data science, and engineering teams to run experiments and improve advertiser outcomes, revenue, and user relevance. Apply deep learning and recommendation techniques within production latency, reliability, and cost constraints.

Build and deploy production machine-learning systems within client environments, covering data discovery, modeling, validation, deployment, scheduling, monitoring, and retraining. Develop forecasting and detection models for imperfect time-series data, establish honest evaluation and KPI frameworks, and ship usable APIs or interfaces. Work directly with client IT and data teams through discovery, demos, and feedback cycles. The role also involves data engineering, software development, basic cloud and DevOps work, and advising clients when ML is not appropriate.

Build and operate scalable ML infrastructure and platform capabilities across cloud and on-premises environments. Develop Python-based developer tooling, services, and production systems supporting experimentation, distributed training, model deployment, and operations. Lead complex initiatives from architecture through rollout, improve reliability and developer productivity, and partner with ML and infrastructure teams. The role emphasizes Kubernetes, AWS, distributed compute, GPU-intensive workloads, observability, and production excellence.

Develop and maintain open-source Python frameworks and ML developer tools, architect scalable libraries, grow early-stage projects, build real-time streaming capabilities, integrate modern frontend technologies, and collaborate with open-source contributors and the broader developer community.

Build and scale machine learning infrastructure, training systems, inference workflows, and agentic AI tools for protein design research. Improve distributed training performance, GPU utilization, reliability, and scalability while partnering with AI scientists and protein engineers. Translate research prototypes into reusable production systems, contribute to technical direction, evaluate emerging ML tools, and support scientific communication.

Build and improve machine learning systems for ad ranking, relevance, and optimization. Responsibilities include developing active learning and LLM-assisted labeling workflows, owning experimentation and evaluation, and deploying low-latency inference services. The role partners with product, data, and platform teams to improve advertiser performance and user engagement while ensuring production reliability, scalability, latency, and data quality. Candidates will use Python, Go, AWS, distributed systems, and AI-assisted development tools.

Own the full lifecycle of clinical text extraction models, from problem framing and annotation strategy through production deployment, evaluation, monitoring, and retraining. Build clinical NLP pipelines, establish defensible quality and error-analysis systems, and apply LLMs using rigorous evaluation, observability, and cost controls. Partner with clinical data and backend engineering teams while addressing PHI protection, de-identification, auditability, and access controls. As the first ML hire, set technical direction and potentially build and lead the future ML team.

Lead design, training, fine-tuning, and deployment of ML and generative models (LLMs, diffusion). Build scalable MLOps pipelines, vectorization and data ingestion, integrate models into microservices for low-latency inference, implement evaluation/alignment/bias-mitigation, optimize models (quantization, distillation), and mentor engineers while influencing the AI product roadmap.