Top Remote Senior Machine Learning Engineer Jobs in Boston, MA

Design, build, and support high-throughput, low-latency LLM inference and data pipelines; collaborate with data scientists to post-train and evaluate models; implement scalable, production-ready systems with strong testing, monitoring, and performance focus; mentor engineers and iterate on architecture, reliability, and user-facing AI applications.

Design, develop, and deploy machine learning models and pipelines to optimize operations. Lead full ML project lifecycle, ensure model evaluation/monitoring, collaborate cross-functionally, mentor junior engineers, and drive continuous improvement in ML applications and processes.

Design and deploy machine learning models for financial document processing, optimize large language models, collaborate with cross-functional teams, and guide junior peers in a fast-paced environment.

The Sr. Machine Learning Engineer will develop and deploy ML solutions for healthcare, manage data pipelines, and work with large datasets to enhance healthcare delivery.

Design and deploy production recommendation and retrieval engines, build data orchestration pipelines for multiple modalities, implement agentic workflow frameworks, and prototype, optimize, and scale models with monitoring, governance, and low-latency SLAs.

Build and improve machine learning systems for ad ranking, relevance, and optimization. Responsibilities include developing active learning and LLM-assisted labeling workflows, owning experimentation and evaluation, and deploying low-latency inference services. The role partners with product, data, and platform teams to improve advertiser performance and user engagement while ensuring production reliability, scalability, latency, and data quality. Candidates will use Python, Go, AWS, distributed systems, and AI-assisted development tools.

Develop, deploy, and maintain scalable ML models (batch and real-time), build end-to-end MLOps pipelines (versioning, CI/CD, containerization, monitoring), analyze large healthcare datasets, bridge research-to-production gaps, present solutions to stakeholders, mentor ML engineers, and apply best practices for model monitoring, drift detection, and retraining.

Build and scale machine learning infrastructure, training systems, inference workflows, and agentic AI tools for protein design research. Improve distributed training performance, GPU utilization, reliability, and scalability while partnering with AI scientists and protein engineers. Translate research prototypes into reusable production systems, contribute to technical direction, evaluate emerging ML tools, and support scientific communication.

Lead technical direction and deliver large-scale ML platform infrastructure including feature store, model serving, experimentation, and training pipelines. Drive architecture, mentor engineers, coordinate cross-team initiatives, resolve system-wide issues (latency, reliability, GPU utilization), and define safe ML deployment paths from registration through rollout, monitoring, and rollback.

The role involves owning and delivering AI-powered features for Calendly, collaborating with multiple teams, and applying machine learning solutions for product enhancement.

Lead development and refinement of machine learning pricing models (especially reinforcement learning) for Airbnb hosts. Collaborate with data scientists, product, and engineers to design, test, integrate, and monitor models, analyze performance, and prioritize projects to improve host outcomes.

As a Senior Machine Learning Engineer, you will design and implement systems for ML and NLP, optimizing models and tools for Clover's healthcare solutions.

Own end-to-end ML lifecycle for pricing and underwriting: improve model accuracy and coverage, reduce infrastructure cost, deploy and monitor production models on AWS, run experiments/backtests, and collaborate with domain experts to inform model improvements and product APIs.

Build and operate production machine learning systems for Airbnb Payments, including LLM agents, real-time fraud detection, anomaly detection, personalization, and checkout optimization. Design, train, deploy, monitor, and continuously improve batch and streaming AI applications at global scale. Partner with product, engineering, operations, and data science teams, establish model governance and testing standards, and mentor engineers.

Own the full lifecycle of production classification and detection models, including transformer fine-tuning, entity detection, behavioral risk scoring, training, serving, versioning, evaluation, drift detection, and retraining. Build SageMaker-based ML systems and define output contracts supporting audit and policy enforcement. Lead the evaluation harness and mentor a co-op while operating as the company’s sole ML engineer.

Own the full lifecycle of clinical text extraction models, from problem framing and annotation strategy through production deployment, evaluation, monitoring, and retraining. Build clinical NLP pipelines, establish defensible quality and error-analysis systems, and apply LLMs using rigorous evaluation, observability, and cost controls. Partner with clinical data and backend engineering teams while addressing PHI protection, de-identification, auditability, and access controls. As the first ML hire, set technical direction and potentially build and lead the future ML team.

Design, train, and deploy scalable ML models (generative, classification, regression). Define feature roadmaps, collaborate with engineering to implement code and APIs, adapt ML methods for distributed/GPU environments, and create evaluation/annotation programs for fine-tuning and performance measurement.

Lead training, evaluation, and deployment of ML models for scene understanding and behavior prediction in autonomous vehicles.

You will train, evaluate, and deploy ML models for scene understanding and behavior prediction in autonomous vehicles, while collaborating with engineers.

Lead design, training, fine-tuning, and deployment of ML and generative models (LLMs, diffusion). Build scalable MLOps pipelines, vectorization and data ingestion, integrate models into microservices for low-latency inference, implement evaluation/alignment/bias-mitigation, optimize models (quantization, distillation), and mentor engineers while influencing the AI product roadmap.

As a Senior Machine Learning Engineer, you will design and maintain ML systems for content recommendations, search, and spam detection, while augmenting user experience and system performance.

As a Senior Machine Learning Engineer, you'll build and deploy ML models for risk and fraud detection, leading technical efforts and collaborating cross-functionally.

Design, build, and deploy high-throughput ML and LLM-powered personalization and agentic systems at consumer scale. Process petabyte-scale data, optimize real-time inference, implement resilient fallback paths, and balance latency, cost, and model quality while collaborating across engineering and product teams.

The Senior Machine Learning Engineer will develop core ML models, manage data pipelines, and collaborate with stakeholders to deliver scalable ML solutions.

The Senior Machine Learning Engineer will build and own production ML systems, manage end-to-end workflow, debug issues, and mentor others.