Top Remote Senior Machine Learning Engineer Jobs in Boston, MA

Design, develop, and deploy machine learning models and pipelines to optimize operations. Lead full ML project lifecycle, ensure model evaluation/monitoring, collaborate cross-functionally, mentor junior engineers, and drive continuous improvement in ML applications and processes.

Design and deploy machine learning models for financial document processing, optimize large language models, collaborate with cross-functional teams, and guide junior peers in a fast-paced environment.

The Sr. Machine Learning Engineer will develop and deploy ML solutions for healthcare, manage data pipelines, and work with large datasets to enhance healthcare delivery.

Design, build, deploy, and operate production machine learning systems for personalization, recommendations, optimization, decisioning, experimentation, and measurement. Build reusable ML platforms, pipelines, and tooling; manage model monitoring, quality, drift detection, retraining, governance, and reliability. Partner with data scientists, engineers, and product teams to productionize models, make architectural decisions, and provide technical leadership through mentorship, reviews, and engineering standards.

Design and deploy production recommendation and retrieval engines, build data orchestration pipelines for multiple modalities, implement agentic workflow frameworks, and prototype, optimize, and scale models with monitoring, governance, and low-latency SLAs.

Design, optimize, and deploy deep learning models for customer behavior prediction. Perform feature engineering, implement research-informed architectures, scale training pipelines, collaborate with client teams, document findings, and uphold engineering best practices.

Design, train, and deploy scalable ML models (generative, classification, regression). Define feature roadmaps, collaborate with engineering to implement code and APIs, adapt ML methods for distributed/GPU environments, and create evaluation/annotation programs for fine-tuning and performance measurement.

Build and improve machine learning systems for ad ranking, relevance, and optimization. Responsibilities include developing active learning and LLM-assisted labeling workflows, owning experimentation and evaluation, and deploying low-latency inference services. The role partners with product, data, and platform teams to improve advertiser performance and user engagement while ensuring production reliability, scalability, latency, and data quality. Candidates will use Python, Go, AWS, distributed systems, and AI-assisted development tools.

Build and scale machine learning infrastructure, training systems, inference workflows, and agentic AI tools for protein design research. Improve distributed training performance, GPU utilization, reliability, and scalability while partnering with AI scientists and protein engineers. Translate research prototypes into reusable production systems, contribute to technical direction, evaluate emerging ML tools, and support scientific communication.

Build and operate production machine learning systems for Airbnb Payments, including LLM agents, real-time fraud detection, anomaly detection, personalization, and checkout optimization. Design, train, deploy, monitor, and continuously improve batch and streaming AI applications at global scale. Partner with product, engineering, operations, and data science teams, establish model governance and testing standards, and mentor engineers.

Own the full lifecycle of clinical text extraction models, from problem framing and annotation strategy through production deployment, evaluation, monitoring, and retraining. Build clinical NLP pipelines, establish defensible quality and error-analysis systems, and apply LLMs using rigorous evaluation, observability, and cost controls. Partner with clinical data and backend engineering teams while addressing PHI protection, de-identification, auditability, and access controls. As the first ML hire, set technical direction and potentially build and lead the future ML team.

Lead training, evaluation, and deployment of ML models for scene understanding and behavior prediction in autonomous vehicles.

You will train, evaluate, and deploy ML models for scene understanding and behavior prediction in autonomous vehicles, while collaborating with engineers.

Lead design, training, fine-tuning, and deployment of ML and generative models (LLMs, diffusion). Build scalable MLOps pipelines, vectorization and data ingestion, integrate models into microservices for low-latency inference, implement evaluation/alignment/bias-mitigation, optimize models (quantization, distillation), and mentor engineers while influencing the AI product roadmap.

As a Senior Machine Learning Engineer, you will design and maintain ML systems for content recommendations, search, and spam detection, while augmenting user experience and system performance.

As a Senior Machine Learning Engineer, you'll build and deploy ML models for risk and fraud detection, leading technical efforts and collaborating cross-functionally.

Design, build, and deploy high-throughput ML and LLM-powered personalization and agentic systems at consumer scale. Process petabyte-scale data, optimize real-time inference, implement resilient fallback paths, and balance latency, cost, and model quality while collaborating across engineering and product teams.

The Senior Machine Learning Engineer will develop core ML models, manage data pipelines, and collaborate with stakeholders to deliver scalable ML solutions.

The Senior Machine Learning Engineer will build and own production ML systems, manage end-to-end workflow, debug issues, and mentor others.

Design, build, and deploy production-grade ML systems for ICS/xOT cybersecurity, including threat detection, anomaly detection, NLP/LLM applications, and scalable data pipelines with observability and MLOps practices for cloud and on-prem environments.

As a Senior AI/ML Engineer, you will design and deploy LLM systems, collaborate with cross-functional teams, and manage model deployment in production environments.

The Senior ML Engineer will develop and deploy full-stack AI solutions, manage LLM integration, and collaborate closely with defense clients to enhance real-world applications in secure environments.

As a Senior MLOps Engineer, you will manage production ML systems, define lifecycle strategies, optimize ML pipelines, and collaborate with cross-functional teams to enhance ML operations.

The Senior Machine Learning Engineer will develop, deploy, and optimize large language models on healthcare data, collaborate with teams, and ensure compliance.

Build and scale ML development infrastructure and Agentic AI tooling. Optimize distributed training (PyTorch/DDP), improve GPU utilization, design multi-cloud Kubernetes environments, and collaborate with ML researchers and engineers to streamline the ML lifecycle.