Sr. Manager, Site Engagement Lead- Central or West

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

The Senior Manager, Site Engagement Lead (SEL) plays a pivotal role in fostering productive and lasting partnerships with clinical trial sites participating in Kymera studies. This position serves as the primary field-facing liaison between Kymera, its CRO partners, and site staff across North America, ensuring that sites are well supported, engaged, and positioned for recruitment success.

The SEL is responsible for executing site engagement strategies, proactively addressing recruitment and retention challenges, and relaying critical site insights to cross-functional teams. The ideal candidate is a self-motivated and collaborative clinical operations professional who thrives on building relationships, solving problems, and contributing to Kymera’s reputation as a sponsor of choice.

 Site Engagement & Relationship Management

• Serve as the “face of Kymera” for assigned clinical trial sites, establishing and maintaining strong, trust-based relationships with investigators, coordinators, and site staff.
• Conduct regular site visits (virtual and in-person) to assess engagement, identify challenges, and recognize achievements.
• Collaborate with sites to develop and implement tailored action plans that accelerate enrollment and support patient retention.
• Facilitate two-way communication between sites and internal stakeholders, ensuring timely sharing of information, materials, and updates.

Operational Support & Collaboration

• Partner closely with Clinical Operations, CRO teams, and internal study leads to align on site engagement goals and recruitment milestones.
• Identify and escalate operational or logistical barriers impacting site performance, and work with cross-functional partners to drive resolution.
• Contribute to the planning and delivery of Investigator Meetings, Site Initiation Visits (SIVs), and study milestone touchpoints.
• Support the adoption of standardized tools, best practices, and communications frameworks across Kymera’s SEL network.

Insights & Continuous Improvement

• Capture and communicate site-level insights to inform trial planning, operational strategy, and risk mitigation.
• Track and report on recruitment metrics, engagement activity, and performance trends across assigned sites.
• Participate in internal debriefs and knowledge-sharing forums to highlight best practices and lessons learned.

Collaboration & Team Contribution

• Act as a role model for collaboration, accountability, and proactive communication within the SEL team.
• Support peer development by sharing successful engagement approaches and field insights.
• Partner with SEL colleagues on regional initiatives to harmonize site support and enhance engagement quality.

• Bachelor’s degree in Life Sciences, Nursing, Public Health, or related field required; advanced degree preferred.
• 5–7 years of experience in clinical research, site management, or clinical operations, with 2+ years focused on site engagement or patient recruitment.
• Strong understanding of clinical trial conduct, GCP, and site operations.
• Excellent communication, relationship-building, and presentation skills.
• Proven ability to work autonomously while maintaining close collaboration with internal and external stakeholders.
• Experience in immunology, inflammation, or respiratory therapeutic areas preferred (e.g., severe asthma).
• Willingness to travel regionally (up to 50%).

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $145,000 – $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.