Senior Manager/Associate Director, Access Marketing

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting, and continue to advance an early-stage pipeline of novel therapeutic candidates. In 2025, we initiated Phase 1 trials for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7). Nav1.7 and Kv7 are important pain targets, and data from these Phase 1 studies are expected in 2026 to support Phase 2 proof-of-concept studies in acute pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Manager/Associate Director, Access Marketing, to join our team. This person will be an integral member of the US Market Access team, responsible for executing the azetukalner access strategy to ensure payer and patient access. This role will play a significant role in the development and execution of the payer value proposition through various market access channels and the patient services marketing materials needed to support patient access. This individual will play a pivotal role in orchestrating communication and alignment across the market access, marketing, and sales to ensure optimal azetukalner coverage and pull-through efforts. Externally, this individual must successfully partner with various agencies to effectively lead the implementation of access marketing strategies and tactical plans.

This position reports to the Director of Value & Access and will be based out of Boston, MA, USA in our Needham office. We will consider other jurisdictions for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.

RESPONSIBILITIES:

• Support the execution of pre-launch and post-launch market access strategy and tactical plan

• Lead the development and evolution of a strong product value proposition for payers, population-based decision-makers, and channel customers

• Lead the development of patient- and office-facing materials and enhance resources to support patient access

• Develop and gain approvals for access marketing tactics and materials that effectively communicate the value story. This may include items “above-brand” and/or branded promotional pieces through internal review process (ex. PRC), training of internal stakeholders (ex. field account teams), and development of KPIs to measure effectiveness

• Collaborate with medical affairs and HEOR/RWE to inform real-world evidence generation plans and ensure evidence generation activities meet the needs of payers

• Collaborate across the patient access team to identify opportunities for evolving office and patient support messaging

• Act as the field account team liaison by interfacing with the account directors to keep a pulse check on customer needs/market access trends and ensure field insights are used to refine and improve strategic considerations and/or field tool development

• Identify gaps and opportunities in the evolving market access landscape, especially as it relates to best practices when supporting field account team engagement and pull-through initiatives

• Coordinate and contribute to payer market research efforts where applicable (ex. advisory boards, in-depth interviews, syndicated reports, etc.)

• Build cross-functional relationships with key internal stakeholders (HEOR/RWE, Market Access Analytics, Patient Access, Marketing, Sales, Medical Affairs) and external stakeholders (payers, KOLs, professional organizations)

• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans

• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices

• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any

• Some international travel may be required

• Other duties as assigned

QUALIFICATIONS:

• Minimum Bachelor’s degree required; advanced degree preferred (ex. MBA).

• 3+ (Senior Manager level) or 5+ years (Associate Director level) of experience in pharma or biotech industry, including 3+ years of related market access or marketing experience.

• US market access launch experience with pharmacy benefit products preferred.

• Strong understanding of US payer and channel market dynamics and how managed care organizations make decisions across commercial and government channels.

• A highly organized and self-motivated individual who has demonstrated the ability to prioritize and manage multiple projects to meet project objectives, timelines, and budget.

• Ability to take resources, concepts, and tools effectively through internal PRC review processes.

• Proven ability to drive results at a high level of quality.

• Driven by intellectual curiosity, “roll-up your sleeves” attitude, and highly effective despite ambiguity.

• Strong analytical skills with proven ability to effectively analyze data to determine trends and inform strategy

• Excellent oral and written communication skills and presentation skills, especially with senior leadership.

• Up to 20% travel may be required based upon business needs

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.