Jobs at Xenon Pharmaceuticals Inc.

Provide biostatistical support for clinical development programs, including protocol development, statistical analysis plans, analysis specifications, statistical programming, data management input, CRO oversight, and review of scientific reports. Collaborate cross-functionally on clinical deliverables, ensure compliance with SOPs, FDA regulations, ICH guidelines, and CDISC standards, and support ad hoc analyses, manuscripts, presentations, and potential NDA/MAA submissions.

Serves as the strategic HR Business Partner to Commercial Sales and Marketing leadership. Leads workforce planning, organizational design, talent strategy, sales hiring, onboarding, employee engagement, performance management, succession planning, and organizational development. Acts as HR lead for launch readiness, coordinating Talent Acquisition, Total Rewards, HR Operations, Learning and Development, Compliance, and Legal. Advises leaders through rapid growth, commercialization, organizational change, and infrastructure development while supporting an inclusive, high-performing culture.

Provides GCP and GLP quality assurance support for early-stage clinical programs, including quality planning, risk assessments, audits, inspection readiness, compliance consultation, training, CAPA evaluation, root cause analysis, and regulatory inspection support. Collaborates with cross-functional stakeholders to identify and escalate quality issues, maintain data integrity, and advance GLP/GCP quality strategies across pharmaceutical R&D programs.

Manages end-to-end clinical supply activities, including study-specific planning, forecasting, packaging, labeling, distribution, inventory monitoring, accountability, returns, and destruction. Coordinates with clinical, regulatory, quality, CMC, supply chain, and external vendors to ensure compliant and timely site supply. Oversees IXRS specifications and monitoring, vendor budgets, supply releases, documentation, KPI reporting, root-cause analysis, and continuous improvement across international clinical trials.

Lead Quality Control activities for clinical and commercial small-molecule drug substance and drug product programs. Manage specifications, stability studies, reference standards, analytical testing, OOS/OOT investigations, release documentation, method validations, CMC submission reviews, external laboratories, CMOs, audits, and quality systems. Collaborate across CMC, QA, API, and drug product teams while leading assigned staff and supporting regulatory and commercial readiness. Up to 20% domestic and international travel is required.

The Executive Director, Total Rewards will manage and design compensation strategies, ensuring alignment with business goals, compliance, and market competitiveness to retain top talent in North America.

Leads enterprise data integration and engineering capabilities, including APIs, middleware, ELT pipelines, data governance, master data management, and cloud analytics platforms. Designs secure, compliant integrations across ERP, CRM, clinical, research, quality, finance, and commercial systems. Establishes architecture standards, data quality controls, monitoring, validation, and support processes while coordinating internal engineers, vendors, and business stakeholders. The role also provides technical leadership for trusted datasets, regulatory compliance, operational reliability, and commercialization readiness.

The Manager/Senior Manager will lead data management activities for clinical trials, collaborating across functions to design databases and manage vendors, while ensuring compliance with regulations.

Leads operational delivery of multiple Phase 3 clinical trials from startup through closeout. Responsibilities include vendor and CRO selection and oversight, site feasibility, budgets, timelines, risk mitigation, regulatory documentation, cross-functional collaboration, investigator selection, trial metrics, and adherence to ICH/GCP and applicable regulations. The role also mentors staff and supports process improvements and best practices.

Leads revenue recognition and Gross-to-Net accounting under ASC 606, including reserves, monthly close, forecasting, government pricing, reconciliations, and variance analysis. Builds scalable commercial accounting systems, data flows, SOX-compliant controls, policies, and procedures for commercial launch. Partners with Commercial, auditors, vendors, and executives on pricing strategy, financial reporting, guidance, and business performance insights.

Lead development and execution of corporate, investor, executive and R&D communications. Craft messaging, press releases, SEC filing support, earnings calls, IR materials, and executive visibility programs. Coordinate across Finance, Legal, R&D, and Commercial; manage IR events, investor meetings, website content, competitor monitoring, budgets, and stakeholder relations. Support issues management and investigator communications. Travel up to 15%.

Lead scientific contribution to design, execution, analysis, and interpretation of clinical trials for neuroscience programs. Draft and review clinical and regulatory documents, collaborate cross-functionally and with CROs/investigators, monitor safety and efficacy data, perform literature review, support study start-up and training, and help develop development strategies, SOPs, and scientific communications.

Lead commercial data management for a pre-launch/launch biotech product: build governed commercial data ecosystem, own MDM for HCP/HCO/payer identities, manage data quality and stewardship, coordinate vendors and data platforms, translate business needs to data requirements, and enable reporting-ready datasets to support analytics and launch decision-making.

Lead Quality Control for clinical and commercial drug substance and product programs, managing analytical testing, release and stability programs, reference standards, specifications, OOS/OOT investigations, vendor/CMO oversight, regulatory CMC QC content, audits, and cross-functional collaboration to ensure cGMP and ICH compliance.

Lead development and execution of US HCP education strategy to support brand and launch objectives. Design and run peer-to-peer programs, congress strategy, digital learning, workshops and advisory boards. Integrate cross-functionally with Medical, Sales, Market Access, and Compliance. Manage KOLs, agencies, budgets, KPIs, and analytics to drive HCP adoption and launch readiness.

Lead implementation, configuration, and day-to-day operations of Quality and Supply Chain IT systems (Veeva, iStability, Oracle Fusion, SAS, Egnyte). Partner with stakeholders and vendors, author and review SDLC deliverables, manage integrations/APIs, perform system administration, user/licensing management, onboarding/training, vendor relationships, change control, and ensure compliance with company IT processes.

Lead design, build, and execution of Xenon’s U.S. commercial sales organization. Define field structure, hire and develop national sales leadership and reps, set performance frameworks, partner cross-functionally (Marketing, Market Access, Medical Affairs, Ops, Legal), drive launch readiness and execution, manage budgets, and use data to optimize targeting and resources. Support KOL engagement, payer strategy, and compliant sales operations.

Lead payer engagement for the West region to secure rapid formulary coverage and access parity for Xenon products. Build and maintain strategic payer relationships, develop account plans, negotiate contracts, align with Medical Affairs and Value & Access, support field pull-through and training, deliver payer insights, manage budgets, recruit and coach staff, and represent Xenon at industry conferences. Some international travel may be required.

Lead U.S. payer market access for Azetukalner, building relationships with national/regional payers, securing formulary coverage and contracting, developing account strategies, collaborating with Commercial, Medical Affairs, and HEOR, supporting field teams, and representing Xenon at industry conferences to ensure rapid patient access.