Senior Director, Supply Chain, Logistics

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting, and continue to advance an early-stage pipeline of novel therapeutic candidates. In 2025, we initiated Phase 1 trials for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7). Nav1.7 and Kv7 are important pain targets, and data from these Phase 1 studies are expected in 2026 to support Phase 2 proof-of-concept studies in acute pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Director, Supply Chain, Logistics, to join our Supply Chain Management team. The candidate will be responsible for supply chain logistics across a number of small molecule drug development programs in support of Xenon’s clinical trials and future Commercial product. The Senior Director, Supply Chain, Logistics, will lead all import and export trade compliance activities for the business, as well as the logistics, warehouse, distribution, and 3PL functions.

The Senior Director, Supply Chain, Logistics will build a highly efficient and effective global logistics team by overseeing import trade compliance and customs broker, freight forwarder and carrier management. The Senior Director, Supply Chain, Logistics will also manage a team responsible for coordinating inbound and outbound shipping, warehousing, 3PL and transportation ensuring delivery to patients. The candidate will collaborate closely with the CMC and Supply Chain Management teams, as well as with key internal stakeholders such as Finance, Clinical Operations, Regulatory Affairs, and Quality Assurance.

This position reports to the Executive Director, Supply Chain, and will be located in Boston, MA, USA in our Needham Office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

• Build and establish a global trade program ensuring compliance to U.S. Customs and Border Protection (CBP) regulations and other global jurisdictions including HTS classification, valuation, and country of origin determination.

• Liaise with customs broker(s) to oversee all import and export filings and customs bond management. Manage all import licenses, permits, and certifications as required by government agencies.

• Manage selected freight forwarder and freight carrier relationships. Monitor all shipments to ensure most cost efficient and timely routing. Track all freight movement, and associated inventory; inform business partners of delivery status.

• Oversee logistics operations including parcel/LTL carrier interactions, document preparation, and material handling for the parts department and the repair facility.

• Develop and provide support for warehouse, distribution and 3PL (including serialization) management team, systems, and processes, as required. Drive excellence in processing to meet customer needs. Manage preventative maintenance of warehouse equipment and tools.

• Develop and implement continuous improvements in warehousing, distribution, reverse logistics, trade compliance, and 3PL management strategies.

• Prepare, develop, and monitor KPI metrics for all aspects of Logistics and Distribution and provide updates and recommendations that improve overall customer satisfaction and profitability. Provide all Supply Chain groups with all required business analytics and reporting. Conduct formal reviews of 3rd party service level agreements (SLAs) to maintain best in class performance while minimizing freight and accessorial expenses.

• Effectively partner with in-direct procurement vendors on key activities, as needed.

• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans.

• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies,

• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.

• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

• Some international travel may be required.

• Other duties as assigned.

QUALIFICATIONS:

• Bachelor’s degree in health sciences, life sciences or physical sciences (or equivalent) with 10+ years’ experience in the pharmaceutical/biotechnology industry.

• Experience and deep knowledge of pharmaceutical Supply Chain Logistics, Trade Compliance, warehousing, and 3PL as they pertain to people, process and technology needs.

• Thorough knowledge of Good Manufacturing Practices (GMP), Good Clinical Practices (GCP), Good Distribution Practices (GDP), International Conference on Harmonization (ICH) Guidelines and other relevant global pharmaceutical regulations, guidelines and directives.

• Experience with Master Data and ERP systems, as well as planning applications [design, implementation, and user acceptance testing (UAT)] is required.

• Proficiency with Microsoft applications, electronic data capture systems and inventory management systems.

• Excellent written and oral communication skills, including the ability to communicate with scientific and non-scientific personnel.

• Excellent attention to detail and commitment to providing accurate, high-quality work.

• Good organizational skills and the ability to manage multiple competing priorities.

• Strong interpersonal and team skills to work both independently and collaboratively as part of a multidisciplinary team.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.