Senior Director, SOX Compliance

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Title: Senior Director, SOX Compliance

Department: Accounting

Location: Waltham, MA (Hybrid 3 days per week)

About Madrigal

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Position Overview

Madrigal Pharmaceuticals is seeking an accomplished Senior Director, SOX Compliance to lead the company’s enterprise-wide Sarbanes-Oxley (SOX) program. This role will be instrumental in making updates to Madrigal’s current control environment, focusing on ensuring a continued sustainable control framework that supports Madrigal’s global commercial expansion and public company responsibilities. The Senior Director will collaborate across functions to strengthen internal controls, mitigate risk, and ensure compliance with SOX 404 requirements while fostering a culture of operational excellence and accountability.

Key Responsibilities

SOX Program Leadership

• Maintain and enhance Madrigal’s SOX compliance program, including scoping, risk assessment, control design, documentation, testing, remediation, and ongoing monitoring.
• Partner with Finance, IT, Legal, HR, and business operations to ensure controls are properly designed and operating effectively across all key processes and systems.
• Lead the annual SOX risk assessment and control initiatives to ensure compliance efforts are efficient and aligned with business priorities.
• Lead annual internal and external process walkthroughs.
• Manage relationships with external auditors and consultants to ensure timely coordination of SOX testing and reporting.
• Drive continuous improvement of SOX-related processes, automation opportunities, and control environment maturity.
• Lead RFP and implementation process for SOX software.

Cross-Functional Collaboration & Governance

• Serve as the primary point of contact for SOX matters across the organization, including executive management and the Audit Committee.
• Communicate control deficiencies, testing results, and remediation progress in a clear, actionable manner to senior leadership.
• Partner closely with Finance and IT leadership to ensure alignment between control requirements, system implementations, and process changes.
• Provide strategic insight and guidance on internal control implications of new business initiatives, system implementations, and policy changes.

Risk Management & Continuous Improvement

• Monitor evolving regulatory expectations, PCAOB standards, and best practices in internal control frameworks (e.g., COSO 2013) to ensure Madrigal remains compliant and forward-looking.
• Evaluate emerging risks and operational changes that could impact the control environment, proposing proactive mitigations where appropriate.
• Promote a strong control culture throughout the organization by training and mentoring control owners and stakeholders.

Qualifications and Skills Required

• Bachelor’s degree in Accounting, Finance, or related field; CPA or CIA required.
• 15+ years of progressive experience Finance with 5+ years in SOX compliance, internal controls, and risk management — ideally including both public accounting and corporate experience in the biotech or pharmaceutical industry.
• Proven success building or transforming a SOX function within a complex, global organization.
• Deep knowledge of SOX 404 compliance, COSO frameworks, internal controls, and PCAOB standards.
• Strong understanding of IT general controls (ITGCs), automated controls, and system implementation risk.
• Exceptional communication and leadership skills with the ability to influence and align stakeholders across all levels of the organization.
• Demonstrated ability to build and mentor a high-performing team and effectively manage external partners.
• Willingness to travel up to ~10% (domestic and international).

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $245,000 - $299,000 per year.

#LI-Hybrid