Scientist II or Senior Scientist, Targeted Proteomics

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

• Develop, optimize, and implement targeted proteomics analysis workflows, including automated enrichment strategies, to deliver precise, accurate, and sensitive protein measurements that inform drug discovery and development decisions.
• Collaborate cross-functionally to implement and qualify assays that drive pipeline decision-making.
• Communicate proactively with project teams and within the proteomics function to coordinate sample availability, align timelines, and ensure timely delivery of high-quality results.
• Manage and oversee activities at contract research organizations (CROs), including assay transfer, qualification, and performance monitoring, ensuring adherence to project specifications, timelines, and data quality standards.
• Perform targeted protein mass spectrometry (MS) assays using state-of-the-art LC-MS systems—including nano-LC and Orbitrap platforms—to determine pharmacodynamic (PD) effects, quantify biomarkers, and qualify assays for clinical studies.
• Prepare samples from a wide variety of biological matrices (cultured cells, tissues, plasma, biofluids) from both human and preclinical species using manual and automated bead-based workflows.
• Perform and interpret quantitative proteomics data analyses using software such as Skyline, MaxQuant, DIANN, and Spectronaut; generate clear, data-driven reports for cross-functional stakeholders.
• Maintain, qualify, and troubleshoot HPLC and MS instrument performance to ensure reliability and reproducibility.
• Present scientific results and strategic recommendations to internal project teams, senior leadership, and external collaborators in a clear, concise, and influential manner.

• PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with a minimum of 2 years of experience in targeted, mass spectrometry–based proteomics in an industry or startup biotech setting; or BS/MS with 8+ years of relevant experience.
• Broad expertise in targeted proteomics, including:
• Development and deployment of highly multiplexed and sensitive PRM or MRM stable isotope–labeled peptide assays using DDA and DIA data.
• Development of immunoaffinity enrichment methods to enhance MS sensitivity.
• Optimization of protein recovery from complex biological matrices (cells, tissues, plasma, biofluids) and various sample formulations (fresh, frozen, FFPE) across preclinical species.
• Operation, maintenance, and troubleshooting of nanoLC and Orbitrap MS instrumentation.
• Quantitative analysis and report generation using Skyline and related proteomics data tools.
• Demonstrated ability to independently analyze, interpret, and clearly communicate targeted proteomics data and conclusions to multidisciplinary teams.
• Proven success collaborating across functional areas and managing CRO relationships to deliver qualified assays that support drug discovery and clinical development.
• Strong organizational, problem-solving, and time-management skills with the ability to prioritize multiple projects to meet TPD drug discovery timelines.
• Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to both technical and non-technical audiences.
• Familiarity with regulatory filings (e.g., IND) and qualification of MS assays for clinical applications preferred.
• Working knowledge of automated sample processing, including immunoaffinity capture MS assays, is a plus.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $90,000 – $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.