Research Scientist

Job Description

General Summary:

Vertex Pharmaceuticals is seeking a highly motivated and innovative Research Scientist with expertise in Immunology and Molecular Cell Biology to join our Functional Genomics group in the Human Assays Technology Department. The successful candidate will play a critical role in advancing our drug discovery efforts by designing and executing cutting-edge assays, unraveling disease biology, and uncovering therapeutic mechanisms of action. The ideal candidate will have foundational knowledge in chronic inflammatory disease biology and technical expertise in the molecular biology of immune cell signaling pathways.

Key Duties and Responsibilities:

• Design and execute flow cytometry-based experiments for molecular characterization of immune cell composition from primary human tissue samples.
• Design and execute molecular profiling experiments using spatial transcriptomics, single cell RNA sequencing, and proteomics.
• Support processing of samples for Next-Generation Sequencing (NGS).
• Support development for miniaturization and automation of screening assays.
• Design and execute functional genomics studies for target engagement and mechanism of action studies of therapeutics.  
• Collaborate with Data and Computational Sciences to develop and apply data-driven approaches, including AI/ML, for analyzing complex biological datasets.
• Maintain rigorous and accurate record-keeping using electronic lab notebooks (ELNs).
• Analyze and interpret experimental data and effectively communicate results across cross-functional teams.
• Collaborate with teams across multiple sites to drive research projects forward.

Knowledge and Skills:

• Strong expertise in Immunology and chronic inflammation diseases, with a deep understanding of molecular and cell biology techniques.
• Proven experience in designing and executing experiments in a laboratory setting.
• Excellent organizational skills with a commitment to meticulous record-keeping.
• Strong communication and collaboration skills, with the ability to work effectively in a cross-functional and multi-site team environment.
• Basic computational skills to analyze NGS-based and complex biological data sets with an interest in developing this skill set.

Education and Experience:

• Ph.D. (or equivalent degree) in Immunology, Molecular Biology, or a related field with 0-3 years of industry experience.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.  

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]