General Manager, Rare Diseases

The Role:

As the General Manager for Rare Diseases, you will report to the Chief Marketing Officer and have end-to-end accountability for the Rare Disease Business Unit (BU), including mRNA-3927 for Propionic Acidemia (PA), mRNA-3705 for Methylmalonic Acidemia (MMA) and a pipeline of pre-clinical candidates. This is an enterprise-level leadership role with cross-functional accountability.

In addition to managing the P&L, setting strategy and leading commercialization efforts, you will integrate activities across critical functions such as Manufacturing, Research and Clinical Development. While you will have dotted-line functional reports from these areas, you will also maintain dual accountability to relevant enterprise leaders. This includes ensuring that strategic planning, execution, and communication align with the broader corporate goals and stakeholder expectations.

You will also serve as the Rare Disease Franchise Lead, managing the marketing team directly, while also acting as a key integrator across internal teams to drive prioritization, resourcing, and global-to-local readiness for successful asset launches and long-term portfolio growth.

Here’s What You’ll Do:

• Lead Moderna’s Rare Disease Franchise with full strategic, operational, and financial accountability 

• Manage the Business Unit P&L

• Own the integrated franchise strategy, including pipeline prioritization, lifecycle planning, and long-range forecasting

• Develop compelling business cases and value narratives that shape investment and development decisions

• Represent Rare Disease in governance forums and drive cross-functional priority-setting aligned with company strategy

• Orchestrate execution across Marketing, R&D, Medical, Access, CMC, and Supply to deliver launches on time and within budget

• Shape the go-to-market model, brand strategy, and external positioning to ensure global readiness and local adaptability

• Partner with country and regional teams to drive alignment, insight-sharing, and sustained execution across markets

• Build and scale commercial infrastructure and capabilities to support asset launches and portfolio expansion

• Identify and develop long-term opportunity spaces and commercial innovation within the rare disease landscape

• Lead structured planning, forecasting, budget management, and KPI tracking across the franchise

• Influence enterprise-level portfolio prioritization and long-term growth strategy through active participation in global forums

Here’s What You’ll Need (Minimum Qualifications):

• Bachelor’s degree required

• 15+ years of progressive experience with significant commercial leadership exposure

• Proven track record in end-to-end portfolio leadership, including launch execution, and lifecycle management

• Direct U.S. launch experience in rare or specialty disease areas

• Experience leading high-performing teams and cross-functional collaborations

Here’s What You’ll Bring to the Table (Preferred Qualifications):

• Full P&L ownership and accountability for the BU

• Experience building and scaling commercial infrastructure in emerging or fast-growth therapeutic areas

• Depth in rare or ultra-rare diseases, with working knowledge of clinical and regulatory pathways.

• Strong understanding of global healthcare systems, access models, and payer engagement

• Demonstrated success building and scaling teams in ambiguous or early-growth environments

• Proven ability to influence across R&D, Medical, Access, and G&A functions

• Strategic thinker with high learning agility, systems orientation, and disciplined operational follow-through

• Executive presence with clear communication and alignment-building skills across senior leadership.

At Moderna, we believe that when you feel your best, you can do your best work.  That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between.

• Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs
• A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
• Lifestyle Spending Accounts to personalize your well-being journey
• Family planning and adoption benefits
• Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
• Savings and investment opportunities
• Location-specific perks and extras

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.  

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. 

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. 

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. 

Our Working Model 

As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. 

Moderna is a smoke-free, alcohol-free, and drug-free work environment. 

Equal Opportunities

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law.  Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. 

Accommodations

We’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. 

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at [email protected]. 

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