Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
Job Summary:
The Director, Compliance Operations is a key strategic and operational leader responsible for driving the execution and continuous enhancement of Madrigal’s enterprise Compliance Program. This individual serves as a cross-functional business partner, embedding compliance principles into business operations while enabling proactive risk mitigation and regulatory readiness.
This role balances hands-on program execution with leadership-level responsibilities, contributing to long-term functional strategy, influencing key stakeholders, and shaping compliance infrastructure to scale with the organization’s growth. The ideal candidate brings deep pharmaceutical compliance expertise, a collaborative mindset, and the ability to lead initiatives in a fast-paced, evolving environment.
Key Responsibilities
- Lead the development, implementation, and continuous improvement of compliance operations infrastructure that supports a strong ethical culture across the organization.
- Serve as a strategic partner to business functions, translating complex regulatory requirements into actionable, risk-based compliance solutions.
- Oversee the management, optimization, and adoption of compliance tools, dashboards, and reporting systems to monitor program effectiveness.
- Facilitate Executive Level Contributions Review Committee meetings, including agenda planning, tracking action items, and synthesizing outcomes for executive visibility.
- Collaborate with Legal, Medical, Commercial, and other stakeholders to review, assess, and document high-risk activities (e.g., HCP engagements, sponsorships, advisory boards).
- Provide direction for the development and dissemination of compliance policies, SOPs, and guidance—ensuring alignment with regulatory expectations and business needs.
- Design and deliver targeted, role-specific compliance training and communications that support awareness, accountability, and behavioral change.
- Support enterprise risk assessment processes, including data analysis, stakeholder engagement, and remediation tracking.
- Analyze outcomes from audits, investigations, and monitoring activities, identifying themes and advising on continuous improvement opportunities.
- Stay abreast of evolving healthcare laws, regulations, and enforcement trends (e.g., OIG, DOJ, PhRMA, state-level requirements); apply insights to refine program elements.
- Build relationships and influence across functions to embed compliance into strategic and operational planning.
- Lead or contribute to enterprise-wide compliance projects, workstreams, and systems implementations as needed.
Qualifications:
Education
- Bachelor’s degree required; advanced degree (e.g., JD, MPH, MBA) preferred.
Experience
- 9–12 years of progressive experience in pharmaceutical, biotech, or life sciences industry, with at least 3–5 years in a leadership or matrixed role.
- Proven ability to lead cross-functional initiatives and influence at all levels of the organization.
- Strong knowledge of healthcare compliance frameworks, regulatory requirements, and industry codes.
- Experience building or scaling operational compliance tools, systems, and workflows.
- Demonstrated success in policy development, risk assessments, and compliance training programs.
- Excellent written and verbal communication skills; able to convey complex concepts to diverse audiences.
- Strong project management and organizational capabilities; comfortable managing multiple priorities in a dynamic environment.
- Travel up to ~25%, including occasional overnights for field monitoring or business meetings.
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $207,000 to $253,000 per year.
All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].
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