Execute experiments on transcription factors to inform target engagement, utilizing proteomics techniques and collaborate with various teams for discovery initiatives.
In this role you will…
• Execute experiments to inform target engagement on transcription factors using a variety of approaches which include tissue cell culture, automated workflows and characterization using mass-spectrometry based proteomics
• Execute high-throughput global proteomics characterization of transcription factors using isotope labeling, TMT, alternative proteases, targeted proteomics (PRM or equivalent) label-free workflows
• Generate data in a timely manner; support lead discovery initiatives and regularly contribute at the bench
• Work closely with senior staff to set experimental strategy, project goals, and timelines to drive projects toward successful completion
• Work closely with biology, biochemistry, chemistry and compound management teams in early discovery to optimize screening on high-value transcription factors
About you…
• You have a B.S or M.S in chemoproteomics, chemical biology, biochemistry or analytical chemistry
• You have 1-3 years of experience in industry
• You have knowledge of proteomics principles and hands-on experience in mass spectrometry-based quantitative proteomics that includes DDA, DIA and/or LFQ
• You may have experience in targeted proteomics and TMT-based workflows,
• You may also have understanding of proteomics sample preparations using both 96- and 384-well plate formats using SP3
• You may have prior experience with assay development, sample prep automation, HPLC fractionation
• You have a desire to work in a lab-based role within a highly adaptive, fast-paced collaborative environment and can creatively solve problems through innovation and communication
• You have self-motivation, great decision making, organizational, analytical, interpersonal and communication skills
This is a 6 month contract position through end of year 2026 with possibility for extension.
Flare is proud to foster a diverse, equitable and inclusive company culture that embraces all people; this is key to who we are, what we do and what we believe. To ensure that we continue to incorporate everyone’s perspectives and experience, we never discriminate based on race, religion, national origin, gender identity or expression, sexual orientation, age, or marital, veteran, or disability status. All your information will be kept confidential in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
TO ALL AGENCIES: Please, no phone calls or emails to any employee of Flare about our openings. All resumes submitted by search firms/employment agencies to any employee at Flare via email, the internet or in any form and/or method will be deemed the sole property of Flare, unless such search firms/employment agencies were engaged by Flare for this position and a valid agreement with Flare is in place. In the event a candidate who was submitted outside of the Flare agency engagement process is hired, no fee or payment of any kind will be paid.
Top Skills
Dda
Dia
Hplc
Lfq
Mass Spectrometry
Proteomics
Tmt
Flare Therapeutics Cambridge, Massachusetts, USA Office
Cambridge, MA, United States
Similar Jobs
HR Tech • Information Technology • Software
The Product Operations Manager ensures efficient product development by optimizing governance, tooling, and communication across teams, driving consistency and quality in product releases.
Top Skills:
JIRALaunchdarklyMiroSlack
Fitness • Hardware • Healthtech • Sports • Wearables
The role involves developing automated test software for manufacturing tests, analyzing results, and optimizing processes while ensuring team collaboration and effective communication.
Top Skills:
C#C++GitPython
Healthtech • Information Technology • Security • Software • Cybersecurity
The Associate Renewals Manager manages the subscription renewal process, drives revenue retention, negotiates contracts, and collaborates with internal teams.
Top Skills:
Salesforce
What you need to know about the Boston Tech Scene
Boston is a powerhouse for technology innovation thanks to world-class research universities like MIT and Harvard and a robust pipeline of venture capital investment. Host to the first telephone call and one of the first general-purpose computers ever put into use, Boston is now a hub for biotechnology, robotics and artificial intelligence — though it’s also home to several B2B software giants. So it’s no surprise that the city consistently ranks among the greatest startup ecosystems in the world.
Key Facts About Boston Tech
- Number of Tech Workers: 269,000; 9.4% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Thermo Fisher Scientific, Toast, Klaviyo, HubSpot, DraftKings
- Key Industries: Artificial intelligence, biotechnology, robotics, software, aerospace
- Funding Landscape: $15.7 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Summit Partners, Volition Capital, Bain Capital Ventures, MassVentures, Highland Capital Partners
- Research Centers and Universities: MIT, Harvard University, Boston College, Tufts University, Boston University, Northeastern University, Smithsonian Astrophysical Observatory, National Bureau of Economic Research, Broad Institute, Lowell Center for Space Science & Technology, National Emerging Infectious Diseases Laboratories
