Senior Principal Scientist, ETCT (ADCs / TCEs)

This is a Hybrid position available at our GSK site in Waltham, MA or Cambridge, MA.

The Extracellular Targeted Cancer Therapeutics (ETCT) Biology Unit within the Oncology Research Unit is seeking an experienced Principal Scientist to contribute to internal initiatives designed to accelerate the build of a targeted biologics portfolio in Oncology. The candidate will collaborate with an experienced team of scientists in using bioinformatic data for target ID/validation and interface with key internal/external business partners to accelerate next generation biologics asset development. The successful applicant will have prior experience managing cross-functional biologics matrix teams with oversight of critical path biology in the preclinical development of novel biologics for cancer therapy.

Responsibilities:

• Lead target discovery screening and early biologics programs, specifically antibody drug conjugates (ADCs) and T cell engaging bispecific antibodies (TCEs).

• Collaborate with internal platform groups to deliver success on externally partnered programs and/or technologies.

• Contribute to analyses of external technology to build next generation ADCs and TCEs.

Basic Qualifications:

• PhD or equivalent experience in Cancer Biology, Pharmacology, Cellular Biology, or related life science fields with 2+ years pharmaceutical or biotechnology industry research and leadership experience in preclinical oncology biologics drug discovery.
• Experience in progressing cancer therapies from target ID to candidate selection and supporting critical path mechanistic biology and/or in vivo translational studies.
• Experience executing target discovery/validation and experimental medicine development of biologics assets for cancer therapy.
• Experience leading cross-functional drug discovery project teams.
• Scientific experience leading hybrid internal/external collaboration teams

Preferred Qualifications:

• Strong organizational and interpersonal skills and the ability to work independently.

• Excellent communication and collaboration skills, with a proven track record of working effectively in a multidisciplinary environment.

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