Top Remote Senior Full-Stack Engineer Jobs in Boston, MA

Lead end-to-end design, development, and delivery of full‑stack features; drive architecture and code reviews; coordinate engineering work, write design docs and tests, and participate in Agile ceremonies. Must have blockchain/crypto experience.

Design, architect, develop, test, and support scalable full-stack applications for a data catalog platform. Own features end to end, contribute to technical strategy and roadmaps, ensure operational excellence, collaborate across distributed teams, and mentor engineers. Build multi-tenant systems supporting high data volumes and near-real-time analytics while applying AI-assisted development practices.

As a Senior Software Engineer, you'll design, develop, and maintain full-stack applications, utilizing TypeScript and modern frameworks while collaborating cross-functionally to enhance user experience and performance.

Lead frontend development for a satellite-data monitoring application serving defense and intelligence customers. Design and implement React and TypeScript features, guide frontend architecture, contribute to backend APIs, mentor engineers through reviews and technical discussions, and collaborate with product managers and designers. Own feature delivery from discovery through deployment while improving state management, data fetching, component design, testing, and frontend best practices.

Build and maintain Alpaca Connect developer-platform experiences using TypeScript, React, and Go. Improve onboarding, app management, compliance review, publishing, consent, and permissions workflows. Design APIs and integrations with identity, account, trading, and market-data systems while creating secure, auditable self-service tools. Own features from design through production and collaborate with Product, Design, Compliance, Support, Partnerships, and Platform teams.

Design and build a high-performance, AI-native web trading experience for sophisticated retail traders. Ship core trading workflows (order entry, positions, blotter, watchlists, alerts), implement trustworthy AI UI patterns, collaborate with backend engineers on low-latency contracts, and iterate quickly with users and stakeholders to deliver end-to-end product features.

Lead full‑stack engineering initiatives to build AI-enabled healthcare products. Ship physician-facing web and mobile features, integrate ML/LLM tooling, architect scalable back-end systems and health data pipelines, and collaborate cross-functionally with product, clinical, and research teams.

Build end-to-end features in a JS/TS stack, designing scalable backend services and responsive real-time frontends. Improve observability, performance, and reliability, collaborate with product/design, and own full-stack implementation from APIs and data models to UI.

Lead architecture and implementation of scalable web applications using NestJS and Next.js. Build and optimize PostgreSQL schemas and queries, implement responsive UIs with Tailwind CSS, integrate LangChain-driven AI features, manage authentication with Clerk, and create end-to-end tests and automation with Puppeteer to ensure launch readiness and reliable user experiences.

As a Senior Fullstack Engineer, you'll design and develop healthcare AI applications, architect scalable solutions, collaborate with teams, and optimize performance.

Lead architecture and rollout of scalable platform services and customer-facing APIs. Define API standards, service boundaries, security, reliability, and developer experience; collaborate with data-platform teams; drive RFCs and complex multi-quarter initiatives; mentor engineers; and contribute across the stack using TypeScript, Node.js, React, and AI tools.

Owns the technical design, development, maintenance, and operations of software products for CMS’s QMARS healthcare systems. Researches technologies, develops proofs of concept, mentors engineers, enforces team processes, and contributes to modernization using Python, React or Angular, TypeScript, and AI technologies. The role requires prior supervisory or lead experience and supports a remote-first team serving public health and healthcare quality improvement programs.

Lead full-stack development for secure, scalable mission planning and command-and-control software supporting space communications programs. Build frontend interfaces and backend services, design APIs, translate mockups into applications, conduct code reviews, improve quality and security, and mentor junior engineers. Work with modern web frameworks, containerized microservices, and highly secure government environments while owning technical problems end to end.

Design and implement full-stack applications for GenAI, build developer tooling, collaborate with product teams, and enhance AI agent delivery.

Build and maintain core platform features, expand Infisical PKI/SSH/KMS product lines, collaborate with CTO and engineers, communicate with enterprise customers, and prototype AI applications for secrets management.

Lead and improve engineering practices for a global pricing platform: design and build scalable Java Spring Boot microservices and React frontends, own APIs and data integrations (Kafka, BigQuery), mentor engineers, drive testability, CI/CD, observability, and adoption of AI-assisted development workflows.

As a Senior Fullstack Developer, you will build and maintain moderation and user-safety applications for Bluesky's Trust & Safety team, collaborating with product teams and improving tools based on user feedback.

As a Senior Full Stack Engineer, you'll design and develop custom Shopify applications, integrate solutions, and collaborate with clients to meet their needs.

The Senior Full Stack Developer will design and build cloud-native applications, using TypeScript, Node.js, and Angular while working in an agile environment.

Design, build, test, and maintain scalable web applications. Create responsive UIs with Angular or React (TypeScript), implement Python/Flask backends and RESTful APIs, design relational schemas, troubleshoot production issues, perform code reviews, and mentor junior developers.

Build and ship features for Cohere’s North AI workspace platform, develop autonomous agents that interact with sensitive enterprise data, and deploy highly performant, secure applications in low-resource environments. Collaborate with researchers to productionize advanced AI models and techniques while contributing across the full stack using Python and React.

Build and own Pepper’s regulated audit platform across internal auditor tools, client and partner portals, data models, integrations, security, and reliability. Develop end-to-end features using TypeScript, React, Node.js, PostgreSQL, and Supabase. Design secure multi-tenant data isolation, authentication, audit logging, evidence integrity, integrations, observability, CI/CD, and deployment workflows. Partner with founders, auditors, CPAs, engineers, and external partners in a high-autonomy environment.

Design, build, and maintain scalable web applications using Python and React. Collaborate with teams and ensure application security and performance.

Design, develop, and maintain web-based UI and REST middleware for federal health IT systems. Participate in Agile/SAFe ceremonies, write design documents, implement features, resolve bugs, and support CI/CD pipelines while collaborating with product, QA, and stakeholders.

Build and operate full-stack, production-ready systems: design and ship AI-native mortgage automation, integrate third-party lending APIs, and architect scalable AWS infrastructure and job processing. Mentor engineers and ensure security, observability, and high reliability.