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Top Principal Data Scientist Jobs in Boston, MA

Reposted 6 Days AgoSaved
Easy Apply
Hybrid
Boston, MA
Easy Apply
222K-275K Annually
Senior level
222K-275K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Biotech • Pharmaceutical
Lead the integration of advanced imaging analytics and AI in drug development, focusing on medical image analysis and clinical trials.
Top Skills: PythonPyTorchTensorFlow
7 Days AgoSaved
Hybrid
Boston, MA
170K-212K Annually
Senior level
170K-212K Annually
Senior level
Consumer Web • eCommerce • Software
The Principal Data Scientist will design and develop machine learning systems, manage data pipelines, and collaborate with teams to improve products and services. This role requires significant experience in ML model deployment and communication with stakeholders.
Top Skills: AWSPythonSagemakerSnowflakeSQL
Reposted 19 Days AgoSaved
In-Office or Remote
Boston, MA
160K-190K Annually
Senior level
160K-190K Annually
Senior level
Digital Media • Fintech • Information Technology • Machine Learning • Financial Services • Cybersecurity • Automation
The Principal Data Scientist will optimize marketing investments through advanced decision support systems, collaborating with multiple business stakeholders, and leading the development of analytics frameworks.
Top Skills: ConoptCplexGamsPyomoPythonScipScipy
Reposted 2 Hours AgoSaved
In-Office
Boston, MA
122K-153K Annually
Senior level
122K-153K Annually
Senior level
Software
The Principal Analytics Engineer leads customer-centric B2B analytics and ML products, ensures scalable design, and collaborates across teams to solve complex problems.
Top Skills: DatabricksPythonRSnowflakeSQL
Reposted 2 Days AgoSaved
In-Office
Boston, MA
117K-201K Annually
Mid level
117K-201K Annually
Mid level
Healthtech • Pharmaceutical • Manufacturing
The Principal Data Scientist will develop data systems for Oncology R&D, design data pipelines, and work with cross-functional teams to translate business needs into data products.
Top Skills: Aws ServicesFsxGlueLambdaPythonRRedshiftSQL
Reposted 2 Days AgoSaved
In-Office
Boston, MA
117K-201K Annually
Senior level
117K-201K Annually
Senior level
Healthtech • Pharmaceutical • Manufacturing
The Principal Data Scientist will standardize linked biomedical and clinical data, focusing on graph-based models while collaborating across teams to create AI-Ready datasets for Oncology R&D.
Top Skills: Amazon NeptuneAzure DevopsDockerGitlabGraph Data ModelingGraphQLJenkinsNeo4JOntologyRdfRest ServicesSemantic TechnologiesSparqlSQL
Reposted 3 Days AgoSaved
In-Office
Boston, MA
150K-195K Annually
Senior level
150K-195K Annually
Senior level
Fintech • HR Tech • Insurance • Consulting
Lead Data Scientist responsible for managing projects in data engineering, model design, and infrastructure deployment while collaborating with clients to develop data-driven solutions.
Top Skills: AWSAzureBicepCloudFormationPythonPyTorchScikit-LearnTensorFlowTerraform
Reposted 2 Hours AgoSaved
Remote
Boston, MA
161K-350K Annually
Senior level
161K-350K Annually
Senior level
AdTech • Digital Media • Information Technology • Other
As a Senior Principal Data Scientist, lead the application of machine learning and AI for ad measurement, optimizing advertiser outcomes through complex model and pipeline development, experimentation, and reinforcement learning systems.
Top Skills: BeamDataflowJaxPythonPyTorchSagemakerScikit-LearnSparkSQLTensorFlowVertex AiXgboost
Reposted YesterdaySaved
Remote
Boston, MA
169K-285K Annually
Expert/Leader
169K-285K Annually
Expert/Leader
Other • Real Estate • PropTech
The Principal Data Scientist will analyze complex datasets, collaborate with teams to define metrics, mentor junior staff, and communicate insights to enhance Zillow Rentals' products and strategy.
Top Skills: DatabricksExcelPythonSQLTableau
Reposted 6 Days AgoSaved
Easy Apply
Remote
Boston, MA
Easy Apply
183K-224K Annually
Senior level
183K-224K Annually
Senior level
Fintech
As a Principal Data Scientist, you'll design and deploy cutting-edge machine learning models to drive financial success for customers and guide technical teams.
Top Skills: AirflowKubernetesMachine LearningMlflowNumpyPandasScikit-LearnSpark
Reposted 10 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Big Data • Information Technology
Design, build, and deploy end-to-end production ML systems for audience targeting, lookalike generation, and propensity scoring. Own ML lifecycle from experimentation to production monitoring, leverage distributed/cloud platforms, implement vector similarity and embedding systems, engineer scalable features, and collaborate with engineering and product teams to ensure model quality and operational reliability.
Top Skills: Aws S3Ci/CdDatabricksFaissGitPythonSnowflakeSparkSQL
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Reposted 10 Days AgoSaved
Remote
Boston, MA
100K-206K Annually
Senior level
100K-206K Annually
Senior level
Healthtech
Lead analytics for claim decisioning by framing ambiguous problems, building scalable data models and pipelines, designing metrics, and deploying analytical and ML solutions. Partner cross-functionally to measure decision quality, operational performance, and payment accuracy, iterating quickly to deliver measurable impact.
Top Skills: DbtLookerPythonSnowflakeSQL
14 Days AgoSaved
Remote
Boston, MA
142K-237K Annually
Senior level
142K-237K Annually
Senior level
Fashion
As a Principal Data Scientist, you'll develop ML systems, improve models, collaborate cross-functionally, and drive innovation in recommendations.
Top Skills: Container OrchestrationDatadogPrometheusPythonPyTorchSparkSQLTensorFlow
Reposted 6 Days AgoSaved
In-Office
Boston, MA
189K-352K Annually
Expert/Leader
189K-352K Annually
Expert/Leader
Healthtech • Biotech
The Senior Principal Data Scientist develops scalable tools for statistical computing in healthcare, providing leadership for data science capabilities, driving automation, and ensuring compliance in complex projects while guiding technical strategy and cross-functional initiatives.
Top Skills: PythonR
Reposted 20 Days AgoSaved
Remote
Boston, MA
169K-285K Annually
Expert/Leader
169K-285K Annually
Expert/Leader
Other • Real Estate • PropTech
Lead data science efforts for the Rentals Shopping pillar, driving strategy, modeling, experimentation, and cross-functional collaboration to improve user experience and business performance.
Top Skills: DatabricksPythonSnowflakeSQL
Reposted 2 Hours AgoSaved
Easy Apply
Remote
Boston, MA
Easy Apply
Senior level
Senior level
Energy
The Data Scientist III/Sr/Principal role focuses on leading complex analytics initiatives, developing analytical solutions, and enforcing coding standards within the business intelligence team, utilizing SQL, Python, and R.
Top Skills: DatabricksPysparkPythonRSQL
Reposted 13 Days AgoSaved
Easy Apply
In-Office
Boston, MA
Easy Apply
Senior level
Senior level
Artificial Intelligence
Lead the Generative AI team at Xometry, focusing on developing and optimizing AI-driven solutions, generative models, and multimodal data processing.
Top Skills: AWSNumpyPandasPythonPyTorchTensorFlow
14 Days AgoSaved
In-Office or Remote
Boston, MA
138K-260K Annually
Expert/Leader
138K-260K Annually
Expert/Leader
Insurance
Responsible for designing and operationalizing advanced data science and AI solutions for insurance, including model deployment and data pipeline development.
Top Skills: Azure Machine LearningDatabricksKnowledge GraphsNatural Language Processing (Nlp)PysparkPythonSnowflakeSQLVector Databases
Reposted 6 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Artificial Intelligence • Big Data • Internet of Things • Software
The Senior Data Scientist will lead innovative data science efforts, leveraging advanced analytics, visualization, and insights from complex datasets to boost productivity.
Top Skills: PythonRScalaSQL
Reposted 6 Days AgoSaved
Remote
Boston, MA
Mid level
Mid level
Artificial Intelligence • Big Data • Internet of Things • Software
Entefy seeks a Senior Data Scientist with a Master's or PhD in a relevant field, and 3+ years of experience. Responsibilities include delivering advanced analytics, leading teams, and extracting insights from datasets.
Top Skills: PythonRScalaSQL
Reposted 10 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Fintech • Software • Financial Services
As a Senior Machine Learning Engineer, you'll build and deploy ML models for risk and fraud detection, leading technical efforts and collaborating cross-functionally.
Top Skills: Machine LearningPythonSQL
Reposted 25 Days AgoSaved
Remote
Boston, MA
Senior level
Senior level
Biotech
The Principal Bioinformatics Data Scientist will develop advanced computational methods and ML models for genomic analysis and lead innovation in bioinformatics, driving integration of large-scale genomic data.
Top Skills: AWSAzureC/C++DatabricksGCPJavaPythonPyTorchRScikit-LearnSnowflakeSQLTensorFlowXgboost
Reposted 8 Days AgoSaved
Easy Apply
Remote
Boston, MA
Easy Apply
Mid level
Mid level
Agency • Machine Learning • Software • Design
Looking for a Data Scientist with experience in ML and AI alignment research to work on client projects and alignment research.
Top Skills: JavaScriptNode.jsPython
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