Senior Scientist - PKPD

At MetrumRG, we’re a diverse, mission-driven team working to transform biomedical decision-making and improve global health. We’re passionate about continuous learning and committed to openly sharing knowledge with the scientific community.

We’re looking for a PK/PD Modeling and Simulation Scientist with a minimum of 5 years of post-doctoral experience to join our collaborative, fast-moving environment. We know our success depends on the well-being and fulfillment of our team, so we strive to make work engaging, rewarding, and fun.

In this role, you’ll contribute to biomedical research, development, and post-marketing efforts across drugs, biologics, devices, and diagnostics. You’ll design and apply quantitative pharmacometric strategies to guide decision-making and accelerate innovation. You’ll also take part in reporting, publications, and ongoing professional development in modeling and simulation.

If you’re energized by scientific growth, meaningful work, and collaboration—we’d love to hear from you.

• Lead interactions with biomedical industry collaborators
• Develop strategies and conduct modeling and simulation to support biomedical decision making
• Develop population pharmacokinetic (PK), pharmacodynamic (PD), exposure-response, disease progression, and/or systems pharmacology models
• Apply models to support decision-making through Monte-Carlo simulation
• Perform model-based meta-analysis of therapeutic area summary-level data
• Perform quality control of modeling and simulation analyses
• Prepare technical reports, manuscripts, and presentations
• Work collaboratively within assigned agile project team(s) to accomplish team goals

• Required: Strong proficiency with a scriptable modeling and simulation language (e.g. R, MatLab, Python)
• Required: Advanced expertise with domain-specific modeling software (e.g. NONMEM, ADAPT, Monolix) and Bayesian modeling software (e.g. Stan, JAGS, OpenBUGS)
• Desirable: Experience with Shiny, Markdown, LaTeX, unix/Linux, subversion, git
• Desirable: A strong understanding of statistical analysis of longitudinal, landmark, and repeated-measures, continuous or categorical data, within a multi-level hierarchy

• Required: M.S. or Ph.D. Degree in Mathematics, Statistics, Pharmacometrics, Pharmacokinetics, Bioinformatics, Chemical or Biomedical Engineering, or related quantitative field
• Required: Minimum five years of experience in PKPD modeling and simulation post-graduate degree

The job frequently requires working at a computer terminal, standing or sitting, and the ability to operate a computer with proficiency.

The work environment is quiet with no adverse conditions.

Metrum Research Group offers competitive salaries and an excellent benefits package. You can read more about us by clicking the link at the top of this page, 'Company Website'.

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