Asimov Logo

Asimov

Senior Scientist, Analytical Development

Posted 10 Days Ago
Be an Early Applicant
Hybrid
Boston, MA, USA
145K-165K Annually
Senior level
Hybrid
Boston, MA, USA
145K-165K Annually
Senior level
Lead analytical development for antibodies, multispecifics, Fc-fusions, proteins, and cell and gene therapy therapeutics. Design experiments, develop and optimize HPLC/UPLC, mass spectrometry, capillary electrophoresis, and related characterization methods, and communicate findings across cross-functional teams. Mentor junior scientists, address complex analytical challenges, improve workflow throughput and reproducibility, and support transparent, data-driven project decisions.
The summary above was generated by AI

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

We are seeking a Senior Scientist to join our Analytical Sciences team. In this role, you will lead analytical efforts to develop and optimize methods supporting the characterization of antibodies and diverse antibody formats (including bispecifics and other multispecifics, Fc-fusions, and other engineered architectures), proteins, and CGT therapeutics. You will actively collaborate with multiple teams, ensuring that your work and insights are aligned with broader program goals. You will apply your technical skills to address complex analytical challenges, continuously grow your expertise, and contribute to a culture of scientific rigor.

About the Role:

  • Lead analytical development efforts for key projects, designing and implementing experiments to generate actionable results.

  • Engage with cross-functional teams to share findings, raise critical analytical issues, and support aligned decision-making.

  • Manage and mentor junior scientists, focusing on experimental design, problem-solving, and fostering a culture of scientific rigor.

  • Ensure transparency and maintain consistent communication with project stakeholders about progress, risks, and results.

  • Continuously develop and apply technical skills in analytical method development (HPLC/UPLC, MS, CE, and other protein characterization techniques) to address evolving project needs.

  • Identify opportunities to improve workflows, analytical throughput, and reproducibility.

About You:

  • Ph.D. in Analytical Chemistry, Biochemistry, Molecular Biology, or related field with 4+ years of relevant biopharma analytical experience, or M.S. with 7+ years of relevant experience.

  • Hands-on experience in analytical method development (HPLC/UPLC, MS, CE, UV, etc.) across diverse antibody formats, with a willingness and aptitude to rapidly expand technical expertise.

  • Strong understanding of antibody structural formats and how format-specific architecture (bispecifics/multispecifics, Fc-fusions, biosimilars, and other engineered constructs) shapes analytical strategy and method selection.

  • Strong collaboration and alignment skills, with the ability to communicate findings clearly and maintain transparency with stakeholders.

  • Experience mentoring junior scientists, guiding them in experimental design and problem-solving, and fostering a culture of rigorous science.

  • Proactive problem-solving mindset, with the ability to apply analytical skills to address complex project challenges.

  • Experience engaging across teams and functions, influencing decisions through effective data-driven communication.

  • Excellent written and verbal communication skills.

We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

HQ

Asimov Cambridge, Massachusetts, USA Office

Cambridge, MA, United States

Similar Jobs

3 Days Ago
Hybrid
Lexington, MA, USA
137K-215K Annually
Senior level
137K-215K Annually
Senior level
Healthtech • Software • Analytics • Biotech • Pharmaceutical • Manufacturing
Leads analytical method development for biologics process development programs. Develops, optimizes, validates, transfers, and manages high-throughput methods using phase-appropriate and AQbD approaches. Partners with process development, analytical development, quality, compliance, and stability teams; supports automation integration, method implementation, training, troubleshooting, lifecycle management, and evaluation of laboratory technologies and vendors.
Top Skills: Ai ToolsAnalytical Quality By Design (Aqbd)Ce-SdsDispensersElisaLab Chip GxiiLaboratory AutomationLaboratory Information Management Systems (Lims)Liquid HandlersMauriceMobile RobotsScara RobotsU/Hplc
6 Days Ago
In-Office
131K-209K Annually
Senior level
131K-209K Annually
Senior level
Healthtech • Biotech
Leads analytical development programs supporting IND, BLA, and MAA filings and post-approval lifecycle activities. Defines specifications, control strategies, comparability plans, assay lifecycle management, and analytical readiness for clinical and commercial manufacturing. Authors regulatory CMC sections and responses to health authority questions while partnering with Quality, Regulatory, Manufacturing, MS&T, and QC teams. Requires biologics or nucleic acid therapeutics expertise, strong regulatory knowledge, and cross-functional leadership.
Top Skills: Analytical ChemistryBiochemistryBiologicsGmpIch GuidelinesMethod ValidationNucleic Acid TherapeuticsTechnology Transfer
11 Days Ago
In-Office
Cambridge, MA, USA
94K-114K Annually
Senior level
94K-114K Annually
Senior level
Healthtech
Develops and optimizes analytical methods for RNA therapeutics, lipid nanoparticles, antibodies, and related components. Performs method development, qualification, validation, transfer, routine testing, troubleshooting, data interpretation, and technical documentation. Collaborates with process development, formulation, research, manufacturing, CRO, and CDMO teams to support CMC strategies and program milestones. Operates and maintains analytical instrumentation while ensuring data quality, integrity, and regulatory compliance.
Top Skills: Cad DetectionConfocal MicroscopyDynamic Light Scattering (Dls)ElisaFdaHplcIchIp-RpLight MicroscopyLipid NanoparticlesRaman SpectroscopyRibogreenRna TherapeuticsRpUhplcUv-Vis Spectrophotometry

What you need to know about the Boston Tech Scene

Boston is a powerhouse for technology innovation thanks to world-class research universities like MIT and Harvard and a robust pipeline of venture capital investment. Host to the first telephone call and one of the first general-purpose computers ever put into use, Boston is now a hub for biotechnology, robotics and artificial intelligence — though it’s also home to several B2B software giants. So it’s no surprise that the city consistently ranks among the greatest startup ecosystems in the world.

Key Facts About Boston Tech

  • Number of Tech Workers: 269,000; 9.4% of overall workforce (2024 CompTIA survey)
  • Major Tech Employers: Thermo Fisher Scientific, Toast, Klaviyo, HubSpot, DraftKings
  • Key Industries: Artificial intelligence, biotechnology, robotics, software, aerospace
  • Funding Landscape: $15.7 billion in venture capital funding in 2024 (Pitchbook)
  • Notable Investors: Summit Partners, Volition Capital, Bain Capital Ventures, MassVentures, Highland Capital Partners
  • Research Centers and Universities: MIT, Harvard University, Boston College, Tufts University, Boston University, Northeastern University, Smithsonian Astrophysical Observatory, National Bureau of Economic Research, Broad Institute, Lowell Center for Space Science & Technology, National Emerging Infectious Diseases Laboratories

Sign up now Access later

Create Free Account

Please log in or sign up to report this job.

Create Free Account