Senior Principal Scientist, Clinical and Biomarker Data Analytics (Neuroscience)

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world.  We provide an inclusive work environment where each person is considered as an individual.  At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

Boston, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America

Job Description:

Johnson & Johnson, is recruiting for a Senior Principal Scientist, Clinical and Biomarker Data Analytics (Neuroscience) to be based at one of our sites in San Diego, CA; Titusville, NJ; Spring House, PA; or Boston, MA.

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Neuroscience team tackles the world’s toughest brain health challenges including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, myasthenia gravis, epilepsy, major depressive disorder, bipolar disorder, schizophrenia, and autism. This patient-focused team helps address some of the most complex diseases of our time.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

The Neuroscience Precision Measures (PM) Team is an integrated scientific organization supporting the delivery of precision therapeutics to patients with CNS disorders across neuropsychiatry, neurodegeneration, and ophthalmology. The team brings together disease experts, biomarker scientists, computational biologists, and leaders in imaging and digital health, and partners closely with Neuroscience Discovery and Development organizations to advance an industry‑leading portfolio of novel mechanisms.

Precision Measures advances measurement science grounded in human data—including fluids, tissues, high‑dimensional biology, and neuroimaging—to support the end‑to‑end portfolio. In close collaboration with internal and external partners, the organization delivers decision‑enabling insights spanning target selection, early and late clinical development, regulatory submissions, and post‑market evidence generation.

The Senior Principal Scientist, Clinical and Biomarker Data Analytics is a senior individual contributor who serves as a scientific and analytical leader supporting neuroscience biomarker discovery, screening funnel optimization, and biomarker endpoint development from discovery through clinical development. Reporting to the Head of Quantitative Imaging and Clinical Biomarkers, the incumbent works in close partnership with Precision Measures and across Neuroscience functions on advanced quantitative and modeling approaches to enable robust biomarker strategies and development decisions.

Operating with minimal direction, the incumbent leads biomarkers analyses across disease areas and measurement modalities. The role requires independent scientific judgment and deep quantitative expertise to evaluate and validate biomarkers in their context of use. The incumbent serves as a key scientific authority on cross‑functional teams and contributes to biomarker strategy development, analytical evidence packages, and expert input.

Key Responsibilities

• Serve as a senior scientific leader for clinical and biomarker data analytics, partnering with Precision Measures and Neuroscience functions to drive data-informed biomarker strategy across discovery and development.

• Lead quantitative analyses supporting biomarker discovery, screening funnel performance, and endpoint development, ensuring analytical rigor and fitness-for-purpose in a clinical trial context.

• Apply advanced modeling and statistical methods to integrate multimodal biomarker data (e.g., imaging, fluid, clinical endpoints) and generate interpretable evidence to inform decision-making.

• Quantify and interpret relationships between biomarkers and clinical outcomes, supporting assessment of biomarker utility for enrichment, stratification, and endpoint development.

• Provide hands-on analytical leadership for biomarker datasets, including data curation, modeling, validation, and interpretation, with emphasis on reproducibility and scalability.

• Partner closely with Clinical, Statistics, Data Science, and operational teams to ensure analytical approaches are aligned with study objectives, protocols, and development timelines.

• Operate effectively in cross functional teams, influencing strategy and execution while leading complex analytical workstreams with broad autonomy and minimal supervision.

• Provide technical guidance and mentorship to project teams, contributing to capability building and scientific excellence across the organization.

• 10% travel

Required Qualifications

• A Ph.D. degree in bioinformatics, biomedical engineering, applied statistics, or related fields.

• At least 10 years of relevant experience.

• A strong publication record, including first author publications in peer-reviewed journals.

• Excellent communication, collaboration, and influencing skills.

• Proven ability to work in teams with diverse expertise and lead projects with broad autonomy.

Preferred Qualifications

• Hands-on experience with biomarker discovery or use of Neuroscience biomarkers in clinical trials.

• Hands-on experience with advanced modeling methods (e.g., statistical modeling, multivariate methods, machine learning, or related quantitative approaches).

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource.

#LI-Hybrid

Required Skills:

Preferred Skills:

Biomarkers, Drug Discovery Development, Industry Analysis, Scientific Research

The anticipated base pay range for this position is :

$137,000.00 - $235,750.00

Additional Description for Pay Transparency:

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
•Vacation –120 hours per calendar year
•Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
•Holiday pay, including Floating Holidays –13 days per calendar year
•Work, Personal and Family Time - up to 40 hours per calendar year
•Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
•Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
•Caregiver Leave – 80 hours in a 52-week rolling period10 days
•Volunteer Leave – 32 hours per calendar year
•Military Spouse Time-Off – 80 hours per calendar year
For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits