Senior Principal Computational Biologist (m/f/d) focus on multi-omics

A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Right now, we are seeking highly qualified candidates to fill the position:
Senior Principal Computational Biologist (m/f/d) focus on multi-omics
Pfizer's cross-functional 'omics ecosystem team is actively seeking a highly motivated, creative, and enthusiastic computational biology researcher with a strong background in data handling, integration and analysis, exceptional full-stack software engineering skills, and a sound understanding of drug discovery and biology. The ideal candidate will have a relevant background in the field of bioinformatics research and will play a key role in our dynamic and pioneering cross-functional team dedicated to advancing the development of a cutting-edge 'omics ecosystem platform for Pfizer R&D. In this role, the candidate will leverage their expertise to design innovative approaches that extract valuable insights from Pfizer's proprietary data and external datasets, enabling the generation of testable hypotheses across the entire drug discovery value chain.
What You Will Achieve
In this role, you will:

• Develop and implement of an omics data platform to enable efficient and scalable analysis of omics data
• Develop and integrate innovative machine learning methods for omics data together with the machine learning team
• Processing, analysis and integration of internal omics datasets
• Curation and integration of relevant datasets from the public domain
• Development of analysis pipelines
• Development of a data dissemination concept for omics data
• Implementation of new methods for omics data analysis and visualization techniques
• Drive collaborations with external companies
• Develop Pfizer omics data strategy together with other functions from the research units
• Onboarding of computational biology community members to data platform and organization of workshops, hackathons, trainings and scientific talks
• Strengthen external visibility and scientific excellence through publishing / presenting work in reputed journals and conference/workshop venues and engaging with the scientific community

Here Is What You Need (Minimum Requirements)

• Formal training in Computational Biology, Computer Science, Biology, Physics, Statistics, or a related technical discipline
• PhD and >5 years of relevant research experience in developing data products and data integration solutions aswell as a sincere interest for computational life sciences
• In-depth knowledge in either single-cell/NGS, functional genomics, genetics or proteomics data and analysis
• Highly creative person with outstanding problem-solving skills to tackle complex analysis tasks in a timely fashion
• Strong full-stack developer with focus on python, in-depth database expertise with a focus on postgres, ETL frameworks. Exceptional programming skills in Python are a prerequisite. Familiarity with pertinent libraries within the Python scientific stack would be highly advantageous
• Nextflow pipeline development
• Hands-on experience in handling, processing, integrating, and analyzing large heterogenous data sets data in a drug discovery research environment
• Strong publication record and demonstrated contributions to the field
• Passion and curiosity for data and proven ability to take ideas from prototype to production.
• Strong interpersonal skills, distinct collaborative attitude, excellent written and verbal communication

Bonus Points If You Have (Preferred Requirements)

• Proficiency in front-end technologies such as typescript, reactjs and browser-based visualization techniques is a plus
• Proficiency in utilizing AI/ML libraries including PyTorch and Lightning is a plus
• Experience with LLMs/RAG systems is a plus
• Proven expertise in software engineering, package development, cloud architectures, CI/CD and software engineering tooling

Together we stand for:
Breakthroughs that change patients' lives - In order to fulfill our corporate purpose, a value-oriented corporate culture guides our actions. Pfizer's values are: Courage, Excellence, Equity & Joy .
Courage: One bold way we are achieving our goals is our company-wide digital transformation strategy. Our flat hierarchies enable short decision-making paths.
Excellence: We focus on what is really important, take responsibility, measure progress and work together in a spirit of trust. Together we rely on an agile way of working that encourages our employees to balance their private and work lives and to promote personal development.
Equity: We believe that different experiences are valuable, which is why every opinion is heard and valued. These experiences and opinions enrich the entire company. In this way, we promote a diverse and inclusive working environment in which colleagues in various Diversity, Equity & Inclusion (DE&I) working groups such as, e.g. Engage Empowered Women, LGBT*IQ , DisAbility, X-Gen.
Joy: If we experience our work as meaningful, we get a lot in return. We achieve this by being proud of the contribution we make, appreciating each other and sharing this with joy and recognition. Our BRAVO Award program gives us an appreciative opportunity to do so. Our employees benefit from a comprehensive company health management "Pfizer in Balance" also during working hours.
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