Join Us in Tackling Autoimmune Disease at Its Root
At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.
When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care.
Why Work at Vor?
Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.
Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.
Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.
Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.
Vor Biopharma is seeking a highly motivated and experienced Senior Director, Program Management to oversee the strategic and operational management of a late-stage clinical program in autoimmune diseases. This individual will provide leadership across cross-functional teams to ensure successful execution of Phase 3 clinical trials, regulatory interactions, and preparation for potential product launch.
The Director will play a pivotal role in aligning scientific, clinical, regulatory, and commercial strategies to drive the program forward in a fast-paced, small biotech environment.
Key areas of responsibility
Program Leadership
- Lead the overall strategy and execution of a global Phase 3 clinical program in autoimmune diseases.
- Leads effective Program Team meetings and presents program strategy to various audiences
- Accountable for the cross-functional execution of one or more program strategy plans, independent of indication or asset.
- Manages program timeline, cost, quality, and risk mitigation as well as timely escalation where needed
- Acts as a leader in the clinical development organization to help build cross-portfolio capabilities. Recognizes consistent challenges and innovates solutions, shares best practices and coaches more junior staff
- Evaluating new assets, determining time to approval, risks, budget, overall development plan
- Manages the effective operations of Vor Bio cross-functional program teams, focused on the development of one or more disease area programs
- Proactively coordinates risk management and ensures contingency and/or risk mitigation plans are developed
Clinical & Regulatory Oversight
- Partner with Clinical Operations, Medical, Regulatory, and Biostatistics teams to ensure Phase 3 trial execution meets quality, compliance, and regulatory standards.
- Support preparation and submission of regulatory documents (NDA/BLA, briefing books, responses to regulatory queries).
- Oversee interactions with the FDA, EMA, and other global regulatory agencies.
Cross-functional Collaboration
- Lead cross-functional core teams (Clinical, Regulatory, CMC, Commercial, Medical Affairs) to ensure integrated program planning and decision-making.
- Partners with the Program Lead and management to drive development of the Program Strategy Plan, adding value by deriving insights from cross-functional discussions and summarizing those insights in a plan that can be easily communicated and implemented across the enterprise
- Facilitates effective business decisions by ensuring integration of key cross-functional input and robust analysis of scenarios. Ensures all decisions are assessed as to their impacts and communicated to stakeholders in a transparent and timely manner
- Provide clear communication of program progress, risks, and mitigation strategies to executive leadership and the Board of Directors.
- Collaborate with Commercial and Medical Affairs to prepare for launch readiness and market access planning.
External Partnerships
- Manage relationships with CROs, investigators, advisory boards, and key opinion leaders in autoimmune diseases.
- Represent the company at scientific conferences, investor updates, and industry meetings as appropriate.
- Operational & Financial Management
- Oversee program budgets, contracts, and resource planning.
- Identify risks and proactively develop contingency plans to maintain trial integrity and timelines.
Qualifications
- Advanced degree preferred (PhD, MD, PharmD, or equivalent in life sciences).
- 12+ years of biotech/pharma experience, with at least 5 years in program or project leadership.
- Proven track record leading late-stage (Phase 2/3) clinical programs, ideally in autoimmune or immunology-related indications.
- Experience in regulatory submissions (NDA/BLA) and health authority interactions.
- Strong knowledge in drug discovery and development and/ or clinical research or related health sciences field with solid understanding of project strategy, interdependencies, and disease content to contribute to strategic discussions
- Experience with operational study start-up into Registrational/Phase 3 trials with a deep understanding of the necessary steps required for market application submissions in multiple regions (US, EU, Japan, China)
- Demonstrated ability to thrive in a small-company, fast-paced environment with limited infrastructure.
- Strong leadership, strategic thinking, and communication skills.
Competencies
- Visionary leadership with hands-on execution ability.
- Deep understanding of clinical development and regulatory pathways.
- Excellent cross-functional collaboration and influence.
- Entrepreneurial mindset and adaptability.
- High integrity and commitment to patients and compliance.
The salary range for this position is expected to be between $223,000 and $254,000 per year. Individual pay may vary based on multiple factors including but not limited to relevant job-related skills, experience, education or training, market factors, and work location.
At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well-being so you can thrive at work and beyond.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
Top Skills
Vor Bio Cambridge, Massachusetts, USA Office
100 Cambridgepark Dr, Suite 101, Cambridge, MA, United States, 02140
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