About The Role
We are seeking a Senior Director, Enterprise Operations to drive a step-function improvement in Lyra’s internal operating leverage and effectiveness. Reporting to the Chief Clinical Operations Officer and working in close partnership with the Chief Information Officer, you will build and execute an enterprise-wide strategy aimed to transform our operating cadence, optimize operational efficiency, and embed AI-driven workflows across all core business functions.
What You’ll Do:
Define Lyra’s multi-year enterprise transformation strategy, prioritizing high-impact initiatives that transform Lyra’s pace of delivery and optimize our internal operations
Drive forward Lyra’s enterprise transformation roadmap, taking cross-functional projects from concept to measurable operational outcome
Establish transformation KPIs (e.g., productivity lift, cost-to-serve reduction, throughput velocity) and track realized ROI against Finance benchmarks
Proactively identify key blockers towards success and identify investments required to accelerate impact
Lead a cross-functional team of strategic operators to drive forward operational transformation projects and partner closely with our dedicated technical teams to bring the technical initiatives to life
Enable a high-performing work culture oriented towards ongoing operational excellence and AI fluency
Requirements:
Leadership Experience: 15+ years of overall business experience, including 8+ years leading large-scale operational or digital transformations at growth-stage or enterprise tech companies
Organizational and Process Redesign: Proven experience identifying key blockers to organizational effectiveness, scoping out potential paths forward, building alignment on the solution, and executing
AI & Tech Capabilities: Proven track record deploying enterprise AI solutions, automation workflows, and/or advanced analytics to drive operating leverage
Financial & Analytical Rigor: Deep expertise in financial modeling, business case development, and tracking post-implementation ROI alongside Finance
Change Management: Demonstrated success leading cross-functional teams through complex organizational and workflow shifts.
Leadership Approach: Strategic executor who thrives in fast-paced, high-growth, and ambiguous environments and is an effective communicator across organizations
Similar Jobs
What you need to know about the Boston Tech Scene
Key Facts About Boston Tech
- Number of Tech Workers: 269,000; 9.4% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Thermo Fisher Scientific, Toast, Klaviyo, HubSpot, DraftKings
- Key Industries: Artificial intelligence, biotechnology, robotics, software, aerospace
- Funding Landscape: $15.7 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Summit Partners, Volition Capital, Bain Capital Ventures, MassVentures, Highland Capital Partners
- Research Centers and Universities: MIT, Harvard University, Boston College, Tufts University, Boston University, Northeastern University, Smithsonian Astrophysical Observatory, National Bureau of Economic Research, Broad Institute, Lowell Center for Space Science & Technology, National Emerging Infectious Diseases Laboratories


