Senior Biomarker Scientist, BioX Genetics and Genomics Chapter

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.

That’s what makes us Roche.

Roche pRED's  BioX Genetics & Genomics (G&G) team within the Pharmaceutical Sciences (PS) organization is seeking a highly skilled and motivated Senior Biomarker Scientist to drive cutting-edge genetic and genomics research. Based in Basel within our BioX Genetics and Genomics Chapter, you will lead the development and implementation of advanced genomic solutions for early clinical trials and preclinical safety studies across diverse disease areas.

This impactful role offers a chance to provide matrix leadership, leveraging your creative ideas and deep technological insights to deliver high-quality, decision-enabling data in early drug development.

As a senior and engaged Biomarker Scientist, you will:

• Collaborate with cross-functional teams to design and execute biomarker studies

• Lead the development, validation, and implementation of clinical genetics and genomics assays for novel therapeutics (e.g., small molecules, large molecules, gene therapies) across therapeutic areas like Cardiovascular & Metabolic, Neuroscience, Ophthalmology, Oncology and Immunology.

• Manage technology/assay transfers and ensure assay reliability with CRO partners.

• Provide translational safety assessments, offering mechanistic insights for various drug modalities (eg. siRNAs and Antisense Oligonucleotides).

• Innovate by evaluating and applying novel genetics and genomics technologies to maximize insights from precious samples.

• Enhance scientific reputation through data interpretation, presentations, and publications.

• Mentor junior scientists and manage external collaborations.

• A PhD, MD, or equivalent in molecular biology, biochemistry, genomics, or a related field, with 5+ years of experience in clinical genomics assay development within pharma (preferred), biotech, or academia.

• Extensive experience in the development, validation, implementation, and GLP-quality reporting of clinical (genetic and genomic) biomarker assays and related understanding of regulations.

• Deep expertise in tissue processing, qPCR/ddPCR, NGS, RNA profiling, single-cell RNAseq, spatial transcriptomics, and multi-omic approaches.

• Strong knowledge of bioinformatic tools for genomic data analysis and interpretation; expertise in population genetics is a plus.

• Familiarity with preclinical safety strategies is a plus.

• A strategic mindset, self-initiative, and strong accountability, with an ability to challenge, be challenged, and continuously learn

• A collaborative spirit, thriving in an agile matrix environment, simplifying complexity, and prioritizing for patient impact.

We offer an impactful role in a state-of-the-art genetics and genomics team at Roche pRED. You will have opportunities to shape pre-clinical safety, early clinical trials, and precision medicine in a collaborative, interdisciplinary research environment. We offer a competitive salary, excellent benefits, and professional development opportunities.

Join us in shaping the future of healthcare through genomics and cutting-edge science.

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.