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Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.
We are looking for a highly motivated Research Associate I to join our DNA & Strain Construction (DNASC) team on a contract basis, with the potential for full-time hire after six months. In this role, you will support our high-throughput molecular biology pipeline, contributing to the efficient cloning, assembly, and sequencing of DNA constructs. You will gain hands-on experience with cutting-edge molecular biology techniques, automation, and process optimization while working in a dynamic synthetic biology environment.
About the Role:
- Perform high-throughput cloning workflows, including PCR, Gibson Assembly, and Golden Gate Assembly to construct plasmids.
- Operate liquid handlers (e.g., Echo, Bravo, Hamilton STAR), run the MiSeq for NGS, and utilize other automation tools for NGS library preparation and molecular cloning.
- Conduct PCR, Golden Gate or Gibson Assembly, plasmid purification, and sequencing prep to validate DNA constructs.
- Maintain accurate sample tracking and documentation in LIMS to ensure data integrity and reproducibility.
- Assist with large-scale plasmid preparations (LSPs) to support internal and external projects.
- Collaborate with scientists and other RAs to troubleshoot workflows and improve efficiency.
- Follow standard operating procedures (SOPs) and contribute to continuous process improvements.
- This role will begin as a full-time, 6 month contract. Dependent on business needs, there is potential for the contract to be extended or converted into a permanent position.
About You:
- B.S. in Biology, Biochemistry, Bioengineering, or a related field (recent graduates encouraged to apply).
- Hands-on experience with molecular cloning techniques (PCR, restriction digestion, ligation, transformation, and plasmid purification).
- Familiarity with DNA assembly methods (Golden Gate, Gibson) and bacterial culturing techniques.
- Comfortable working in a fast-paced lab environment, following protocols, and maintaining detailed records.
- Experience with automated liquid handlers (Echo, Bravo, Hamilton STAR) or NGS workflows is a plus.
- Highly organized, detail-oriented, and able to work independently or as part of a team.
We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.
Asimov Boston, Massachusetts, USA Office
We're in the Fenway neighborhood! Our office/lab is near the Kenmore and Fenway stops on the green line. We also have a shuttle service from Ruggles (orange line) to/from our building. There's plenty of coffee shops, bars, and restaurants nearby too!
What you need to know about the Boston Tech Scene
Boston is a powerhouse for technology innovation thanks to world-class research universities like MIT and Harvard and a robust pipeline of venture capital investment. Host to the first telephone call and one of the first general-purpose computers ever put into use, Boston is now a hub for biotechnology, robotics and artificial intelligence — though it’s also home to several B2B software giants. So it’s no surprise that the city consistently ranks among the greatest startup ecosystems in the world.
Key Facts About Boston Tech
- Number of Tech Workers: 269,000; 9.4% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Thermo Fisher Scientific, Toast, Klaviyo, HubSpot, DraftKings
- Key Industries: Artificial intelligence, biotechnology, robotics, software, aerospace
- Funding Landscape: $15.7 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Summit Partners, Volition Capital, Bain Capital Ventures, MassVentures, Highland Capital Partners
- Research Centers and Universities: MIT, Harvard University, Boston College, Tufts University, Boston University, Northeastern University, Smithsonian Astrophysical Observatory, National Bureau of Economic Research, Broad Institute, Lowell Center for Space Science & Technology, National Emerging Infectious Diseases Laboratories
