COMPANY DESCRIPTION
Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins™, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology.
Abiologics was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.
THE ROLE
We are looking for a highly motivated, experienced cell biologist and assay developer to join our growing team and lead in vitro pharmacology efforts. In this role, the successful candidate will be responsible for conceiving, developing and executing in vitro pharmacology plans to support the progression of the Abiologics pipeline. This role includes hands-on work in the lab, as well as leadership of a cross-functional project team and mentorship of more junior scientists. Occasionally, the incumbent may contribute to in vivo and ex-vivo pharmacology activities to progress projects and the platform. In addition, this role will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company build-out.
KEY RESPONSIBILITIES
- Design, develop and execute cell-based assays to assess SynteinTM activity, target engagement and mechanism of action to drive discovery programs
- Lead cell biology efforts within the Pharmacology team to identify and implement relevant cell-based assays for diverse target classes and disease areas
- Lead a cross-functional project team, including driving strategy for progressing multiple hit series
- Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members
- Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
- Collaborate cross-functionally to enable novel methods, assays and screening workflows
- Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teams to drive design-make-test cycles
- Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings
PROFESSIONAL EXPERIENCE & QUALIFICATIONS
- PhD in molecular or cell biology or related discipline with minimum 7+ years relevant experience (with at least 5 in industry) required
- Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
- Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, ELISA, Western blot, flow cytometry, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus
- Experienced with primary cell culture and characterization, including tissue dissociation
- Experienced in assay development and testing in model systems and human with good understanding of analytical and pre-analytical methods and solutions
- In vivo pharmacology expertise highly desired
- Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays (e.g., intracellular signaling) and interpret complex results
- Disease biology expertise in oncology is highly desirable, with experience advancing compounds from discovery through preclinical development
- Proficiency in laboratory automation and semi-automated screening workflows a plus
- Industry level experience with best practices related to data records creation and maintenance and workflow integrity
- Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality
- Demonstrated ability to lead and grow people in the industry setting
ABOUT FLAGSHIP PIONEERING:
Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
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The salary range for this role is $163,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Abiologics, Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Abiologics, Inc's good faith estimate as of the date of publication and may be modified in the future.
Top Skills
Flagship Pioneering Cambridge, Massachusetts, USA Office
55 Cambridge Parkway, Suite 800E, Cambridge, MA, United States, 02142
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