We are seeking a Principal Research Associate to optimize preclinical science assays for xenotransplantation, requiring extensive experience in cell culture and assay development.
COMPANY MISSION
At eGenesis, we aspire to deliver safe and effective human transplantable cells, tissue and organs utilizing the latest advancements in genome editing.
POSITION SUMMARY
We are seeking an outstanding, highly motivated Principal Research Associate to join our Development team. This role will support preclinical science assay optimization in the context of xenotransplantation. This position provides an excellent opportunity to help develop xenotransplantation products in an exciting and dynamic environment focused on cutting-edge molecular and cellular engineering technology.
In this role, you will be part of a team responsible for generating a cell line derivation pipeline and in vitro assay optimization. The role will involve significant cell culture work, in vitro and ex vivo analyses with porcine, non-human primate, and human cells and biosamples. The ideal candidate will have strong experience in cell culture and assay development, preferably using flow cytometry techniques, and will play a critical role in driving our xenotransplantation organ programs forward.
PRIMARY RESPONSIBILITIES
- Design, execute, and analyze in vitro experiments to support pre-transplant screening in the context of xenotransplantation.
- Develop and optimize a cell line derivation pipeline to be used in immunological in vitro assay experiments.
- Develop and optimize assays to assess immune responses involving different kidney cell subtypes, including using multi-color flow cytometry, Incucyte®, ELISA, and other techniques.
- Perform and assist with assay execution for different organ programs.
- Collaborate with cross-functional teams (analytical development, preclinical, translational, computational biology) to advance projects.
- Interpret experimental data and present findings to internal and external stakeholders.
- Maintain accurate and detailed laboratory records in compliance with regulatory standards.
- Contribute to the preparation of research reports and regulatory submissions.
QUALIFICATIONS
- Bachelor’s degree in Immunology, Biology, or a related field with 8 years of related experience; or master’s degree with 6 years of related experience
- 4-6 years of hands-on experience in immunology within the biotech industry.
- Proficiency in immunological techniques, including flow cytometry, ELISAs, cell culture, and molecular biology methods.
- Strong understanding of the Incucyte® system, multi-color flow cytometry, and primary cell culture.
- Sample management, including collection, processing, storage, and documentation.
- Excellent written and verbal communication skills.
- Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
- Demonstrated ability to manage multiple projects and meet deadlines.
Top Skills
Elisa
Flow Cytometry
Incucyte
Molecular Biology
eGenesis Cambridge, Massachusetts, USA Office
300 Technology Sq, Cambridge, MA, United States, 02139
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