Principal Research Associate, mRNA Process Development

Company Overview

Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.

Position Overview:

Beam is seeking a highly talented and motivated Principal Research Associate to join our growing mRNA Process Development team.  The Principal Research Associate will be responsible for executing late-stage mRNA process development activities, with a focus on downstream purification. The individual will have the opportunity to work with a dynamic and collaborative team across a range of technical areas. They will be tasked with supporting experimental design, execution and data analysis as well as authoring technical documents and reports.

This role is onsite 5 days/week in Cambridge, MA

Responsibilities:

• Support the design and execution of mRNA purification studies to support process development
• Use DoE and other statistical tools to help characterize our processes and to develop control strategies
• Help manufacture materials for use in process development
• Support external and internal tech transfers
• Effectively document, interpret and communicate technical results
• Work cross-functionally to support Beam programs to ensure critical timelines are met

Qualifications:

• Bachelor’s or Master’s Degree in related science with 10 years of relevant experience (e.g. chemical engineering, biochemical engineering, biochemistry etc)
• Experience with mRNA purification technologies is preferred (chromatography and TFF)
• Knowledge of mRNA manufacturing processes
• Highly organized and detail oriented with strong communication skills
• Motivated to learn and to execute process development studies in the lab
• A collaborative mindset