Pioneering Medicines: Scientist, Invitro Pharmacology

What if…

We could harness the power of Flagship’s breakthrough scientific platforms to create entirely new therapeutic modalities — and deliver transformative medicines to patients faster?

Pioneering Medicines, a division of Flagship Pioneering, is building a premier biopharmaceutical R&D organization dedicated to conceiving and advancing life-changing therapies. By integrating and applying Flagship’s innovative platform technologies to serious diseases with high unmet need, we aim to redefine how medicines are discovered and developed. A defining strength of our approach is the ability to combine multiple platforms to generate truly novel and potentially transformative treatments.

About Flagship Pioneering

Flagship Pioneering is a life sciences innovation company that conceives, creates, resources, and develops first-in-category scientific ventures to transform human health and sustainability. Since its founding in 2000, Flagship has originated and fostered more than 100 scientific ventures, generating tens of billions in aggregate value and advancing breakthroughs across biotechnology and sustainability. Flagship’s unique hypothesis-driven innovation model has enabled the creation and growth of an ecosystem of 40+ companies — including high-impact ventures such as Moderna, Tessera Therapeutics, Generate:Biomedicines, Sana Biotechnology, Indigo Agriculture, and Inari — that span cutting-edge platform technologies and therapeutic modalities

Position Summary

Pioneering Medicines is seeking a scientifically rigorous, innovative, and collaborative Scientist to join our In Vitro Pharmacology team. This role is ideal for a PhD-trained scientist with industry experience who thrives at the intersection of in vitro pharmacology and translational science.

The successful candidate will lead in vitro pharmacology efforts for one or more discovery programs, designing and executing critical experiments that inform candidate selection and go/no-go decisions. You will contribute to the evaluation of novel therapeutic modalities across multiple disease areas, including immunology, oncology, cardiovascular, and metabolic diseases.

This role requires deep expertise in cell-based assay development, mechanistic biology, and translational thinking, along with the ability to operate in a fast-paced, highly collaborative environment.

Key Responsibilities

• Provide scientific leadership for in vitro biology and pharmacology activities on designated discovery programs
• Design, develop, and optimize robust, physiologically relevant cell-based assays to evaluate potency, efficacy, mechanism of action, and differentiation of candidate therapeutics
• Develop and execute assays using cell lines, human primary cells, peripheral blood cells, and complex ex vivo systems to support translational strategy
• Drive experimental strategy to rapidly generate decision-enabling data and advance programs toward development milestones
• Collaborate closely with in vivo, translational, platform, and CMC teams to ensure alignment from early discovery through clinical development
• Partner with external collaborators and CROs to design, oversee, and interpret in vitro studies
• Contribute to scientific strategy discussions and present findings to cross-functional stakeholders and leadership
• Mentor and guide junior scientists as appropriate

Basic Qualifications

• PhD in Biology, Pharmacology, Immunology, or a related discipline
• 2+ years of relevant industry experience in drug discovery (biotech or pharma preferred)
• Demonstrated expertise in developing and implementing complex in vitro cell-based assays
• Strong hands-on experience with mammalian cell culture, including primary human cells
• Working knowledge of in vitro pharmacology principles (compound handling, dose-response analysis, potency/efficacy characterization)
• Proficiency in data analysis tools
• Strong experimental design, data interpretation, and scientific communication skills
• Experience maintaining rigorous documentation in ELN systems

Preferred Qualifications

• Industry experience advancing programs from target validation through IND-enabling studies
• Research background in immunology, immuno-oncology, oncology, cardiovascular or metabolic disease
• Familiarity with emerging therapeutic modalities (e.g., small molecules, peptides, biologics etc)
• Track record of impactful scientific contributions, including publications, presentations, or advancement of therapeutic candidates
• Experience managing collaborations with academic partners, biotech/pharma collaborators, or CROs

Why Join Pioneering Medicines?

• Opportunity to work at the forefront of platform-enabled therapeutic innovation
• Exposure to first-in-class and potentially paradigm-shifting treatment modalities
• Highly collaborative, entrepreneurial environment within the Flagship ecosystem
• Ability to shape programs from early discovery to clinical translation
• Culture that values scientific excellence, creativity, and ownership

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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The salary range for this role is $100,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.