Group Leader, Principal Scientist, Quantitative System Pharmacology (QSP)

We are seeking a team member who wants to be part of a diverse, world-class team transforming biomedical decision-making to improve health for all. We are obsessed with learning and we have a passion to participate in the growth of our scientific disciplines. We believe that as we learn, we have a responsibility to share openly with the community.

Our Mission:  At Metrum Research Group, we are driven to improve health and defeat disease, particularly where there are unmet needs. We provide innovative solutions at the intersection of data, science, and technology to generate key insights that impact biomedical decision-making.

If you share our energy and priorities, we would love to hear from you!

Metrum Research Group is looking for a Group Leader to join the Quantitative Systems Pharmacology team.  Join a diverse, multi-disciplinary group of scientists to push the envelope of systems modeling and solve pressing challenges in drug development and biomedical decision making. 

• Provide scientific and professional development guidance to PhD-level scientists
• Oversee scientific execution of projects: from data analyses to modelling workflows to presentations and reporting of results, as the primary interface with clients
• Help define the strategic direction of the group; methodology development, applications, focus areas, publication plans, and training.
• Oversee, review, and prepare scientific reports and presentations
• Participate in business development calls, proposal scoping, and resourcing
• Envision, support, and lead internal research projects pushing the boundaries of knowledge in the QSP-space

• Deeply inquisitive and passionate about mathematical problem solving in biomedicine
• Excellent written and verbal communication skills, demonstrated through a track record of scientific publications, presentations, and/or regulatory filings.
• Proven ability to lead multi-functional teams in fast-paced environment with multiple stakeholders
• Track record of mentoring early career scientists
• Experience developing mathematical models of biological systems from scratch; read and interpret scientific literature, represent the biology via math, parameterize models, execute simulations and communicate results to diverse stakeholders
• Expertise in at least one domain-specific modelling language (Julia, R, Matlab, or Python) with working knowledge of more
• Expertise in dynamical systems modelling and QSP methodologies; e.g. parameter estimation, virtual population generation, and sensitivity analyses.
• Proficiency in statistics and machine learning methods
• Experience using modeling notebooks (e.g. Markdown, Jupyter) LaTeX, subversion and github
• Working knowledge of pharmacology fundamentals, population pharmacokinetics, and exposure-response analyses.  i.e. ability to converse with pharmacometricians
• Working knowledge of cell biology, immuno-oncology, drug development, and biopharma industry.  i.e. ability to converse with biologists and clinicians

• PhD in Engineering, Applied Mathematics, Systems Biology, or equivalent quantitative discipline
• 10+ years post-graduate experience, preferably in biotech, pharma, or biopharma consulting 

The job frequently requires working at a computer terminal, standing or sitting, and the ability to operate a computer with proficiency.

The work environment is quiet with no adverse conditions.

Metrum Research Group participates in E-verify. 

Metrum Research Group offers competitive salaries and an excellent benefits package. You can read more about us by clicking the link at the top of this page, 'Company Website'.

Metrum Research Group is an Equal Opportunity Employer

Metrum Research Group EEO Statement

MetrumRG believes that innovation is cultivated when we challenge each other with new ideas and perspectives. MetrumRG is an equal opportunity employer that is committed to building a diverse and inclusive team. All employment decisions are based on qualifications, merit, and business needs, and we prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, gender identity, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

MetrumRG is committed to providing equal employment opportunities and reasonable accommodations for candidates and employees with disabilities. We encourage all qualified candidates to apply for positions within our organization. If you require reasonable accommodation because of a medical condition for the application or interview process, please contact Scotti Rylands or our Talent and Culture Department, (860)735-7043 x-622, or message us and we will work with you to meet your needs.