Gene Editing Off-Target Safety Lead; Lilly Genetic Therapies

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Gene Editing Off-Target Safety Lead; Lilly Genetic Therapies

Eli Lilly and Company is seeking a Editing Off-Target Lead to join our in Boston, MA. 

Come join the rapidly expanding Gene Therapy team at Eli Lilly! We are responsible for inventing, characterizing, and advancing novel genome editing reagents for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple disease areas and platforms. Our goal is to deliver on the promise of gene editing to patients around the world.

• Develop and execute strategic vision for gene editing safety characterization for multiple programs and serve as subject matter expert on gene editing safety for internal and external stakeholders.
• Establish clear data delivery timelines and quality standards for off-target characterization supporting regulatory submissions.
• Oversee implementation and optimization of IND enabling off-target quantification methods (GUIDE-Seq, UdiTaS, SITE-Seq, ITR-Seq, ONE-seq, etc…) across multiple programs.
• Lead and mentor the Off-target Team and work with a cross-functional team of scientists and engineers spanning, translational gene editing, off-target biology, NGS technologies, and laboratory automation to support the gene editing off-target safety strategy.
• Develop and execute strategic vision for gene editing safety characterization work flows and help establish high-throughput automation capabilities.
• Drive R&D initiatives to incorporate novel assays and emerging technologies into the gene editing pipeline.
• Deliver clear communication of technical capabilities, timelines, and results to diverse stakeholders and executive leadership.
• Support business development activities and external partnerships as needed
• Champion continuous improvement, operational excellence and documentation practices.

• PhD in biology, molecular biology, genetics, bioinformatics, bioengineering, or closely related scientific field with 5+ years of experience, OR Masters in scientific field with 12+ years of relevant industry experience

• Demonstrated experience leading technical teams and managing complex gene editing programs to advanced development milestones including regulatory filings.
• Mastery of gene editing technologies and safety assessment methodologies and de-risking strategies.
• Molecular biology mastery of NGS library preparation, qPCR, DNA & RNA extraction, and related technologies
• Strong background in NGS technologies themselves, and their applications, including quantification, sequencing, and data QC.
• Track record of mentoring and developing scientific talent
• Experience with automation is a plus

• This role may require up to 10-15% travel for conferences or training and will include the opportunity to mentor and train junior scientists.
• The position is located at the Lilly Seaport Innovation Center, 15 Necco St, Boston, MA 02210.

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Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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