Director, Genetic Medicines

The Company
We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.
Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions.  We strive to have workers in the office when needed to interact organically and face-to-face.  Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year.  We respect and value our colleagues for their hard work that requires them to be in the lab every day.  We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility.  We are all one team!

The Team 
The Alloy Genetic Medicines group is innovating a novel RNA-based drug discovery platform, namely “AntiClastic”, spanning the fields of antisense therapeutics to immunomodulating therapeutics. This technology platform was launched by Alloy in 2023 after exclusively licensing its underlying intellectual property which implements a novel spatial conformation of the oligonucleotide developed by Sudhir Agrawal of Arnay Sciences. The team works closely with external partners to discover and develop AntiClastic RNA medicines.
The Role 
In our Director, Genetic Medicines, we are seeking an experienced and motivated individual to lead and coordinate drug discovery and development projects within the Genetic Medicine business unit. This role requires strong organizational skills, a deep understanding of RNA drug discovery and development processes with hands-on experience in antisense or siRNA modalities.
In this role, you will manage and oversee multiple RNA medicine drug discovery and development projects and collaborations with large pharma companies, biotech companies and academic collaborators. You will ensure executional excellence by evaluating scientific strategies, reviewing data in real time and making the necessary scientific adjustments to ensure a successful completion of the project. This role will be reported to the CSO of Genetic Medicines and will serve as the primary point of contact for both internal and external stakeholders. 
How You’ll Drive Impact 

• Drive: Scientific direction and execution of antisense drug discovery and development projects
• Deliver: Work with sense of urgency to deliver key milestones associated with both internal and external project goals, track project budgets and allocate resources effectively
• Collaborate: Collaborate with venture and business teams, ensure alignment between scientific priorities and business objectives
• Communicate: Communicate effectively with key stakeholders externally and internally, fostering productive interactions across different teams

Principal Responsibilities 

• Develop strategies and lead translational aspects of antisense/siRNA drug development projects
• Provide clear direction and support to the project team members to ensure studies are executed to meet the project goals. Regularly review project performance against milestones
• Work with the project team to prepare detailed study reports, presentations and documentations as needed
• Using established project management tools, ensure all the different scientific programs are on track to deliver key milestones
• Resolve conflicts, delays, and other challenges to keep the project on track
• Negotiate with vendors, CROs, CMOs and other external partners to secure resources and services  

Qualifications

• PhD degree in Biology or related science
• 8+ years of experience and strong understanding of antisense/siRNA drug discovery and development projects
• Prior experience working with or leading collaboration with external pharma, biotech or academic partners.
• Proven track record of successful execution and delivery of antisense projects within scope, budget, and timeline
• Attention to detail and commitment to quality
• Strong communication and interpersonal skills

Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match

Health & Family

• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)

Unique Perks

• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

Pay Transparency
At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated annual base salary range is $166,500 - $198,000 with the final offer based on factors like your experience, skills, and alignment with our needs.

Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.

We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help.

Alloy Therapeutics is an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status.  If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at [email protected].  We will make every effort to respond to your request for disability assistance as soon as possible.