Director, DMPK

We are seeking an accomplished and strategic Director, DMPK to lead our drug metabolism and pharmacokinetics function across discovery, development, and post-marketing programs. Reporting to the Head of Clinical Pharmacology, DMPK, and Bioanalysis (CP/DMPK/BA), this highly visible role will manage a team of DMPK scientists and serve as a key subject matter expert. The Director will partner cross-functionally with Clinical Pharmacology, Pharmacometrics, Bioanalysis, and R&D teams to design and execute ADME/DMPK strategies that drive data-informed decisions and regulatory success.

Key Responsibilities

• Lead and mentor a team of DMPK scientists to deliver innovative and effective DMPK strategies from discovery through life-cycle management.
• Serve as a scientific leader and SME on project teams, influencing program direction through expert interpretation of ADME/DMPK data.
• Oversee the design, conduct, and analysis of in vitro and in vivo DMPK studies to support discovery, development, and regulatory filings.
• Author and review DMPK sections for INDs, NDAs, and other regulatory submissions; participate in health authority interactions.
• Manage CRO partnerships and ensure scientific quality, compliance, and efficiency in external studies.
• Drive continuous improvement in DMPK tools, technologies, and capabilities.

Qualifications

• PhD in pharmaceutical sciences, pharmacokinetics, pharmacology, or related field with 8+ years of relevant DMPK experience, or MS with 12+ years.
• Proven track record leading DMPK strategies for small molecules and/or biologics across R&D stages.
• Deep expertise in ADME, pharmacokinetics, metabolism, and regulatory submissions (IND, NDA, MAA).
• Strong leadership, communication, and cross-functional collaboration skills.
• Experience managing CROs and leading successful regulatory interactions.

Preferred Experience

• Working knowledge of PK/PD modeling and simulation tools.
• Experience in oncology and/or neurology programs.

Demonstrated ability to enhance DMPK capabilities and implement innovative approaches.

Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $192,000 - $265,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.​

Deciphera believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable)

• Competitive salary and annual bonus.
• Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
• Generous parental leave and family planning benefits.
• Outstanding culture and opportunities for personal and professional growth.

EQUAL EMPLOYMENT OPPORTUNITY INFORMATION

Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially.  We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.