Bioinformatician I

Site: The General Hospital Corporation

 

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

 

 

Job Summary

The Iafrate Lab in the MGH Molecular Pathology Unit is seeking a highly motivated Bioinformatics Scientist to join our research team. This position will focus on genomic and transcriptomic data analysis. The successful candidate will work closely with biologists, computational scientists, and clinicians to extract meaningful insights from multimodal datasets.
Key Responsibilities
1. Genomic & Transcriptomic Data Analysis
• Perform bulk RNA-seq, single-cell RNA-seq (scRNA-seq), and spatial transcriptomics data analysis
• Conduct Next-Generation Sequencing (NGS) analysis, including variant calling, gene expression analysis, and pathway enrichment studies
• Utilize bioinformatics pipelines (e.g., STAR, Cell Ranger, Seurat, DESeq2, Monocle, Scanpy) for data processing and interpretation
• Work with long-read sequencing (PacBio, Oxford Nanopore) and epigenomics as needed
2. Data Management & Computational Infrastructure
• Develop and maintain data pipelines for sequencing datasets
• Manage data storage, versioning, and retrieval in compliance with FAIR data principles
• Maintain documentation and reproducible workflows using Snakemake, Nextflow, or WDL

 

Required Skills & Qualifications
•    PhD (or MSc with equivalent experience) in Bioinformatics, Computational Biology, Biostatistics, or related field
•    Strong proficiency in Python, R and RStudio, and Bash scripting
•    Expertise in NGS data processing and analysis, including RNA-seq, scRNA-seq, and variant analysis
•    Familiarity with data visualization tools (Shiny, Dash, ggplot2, Matplotlib)
•    Experience working in Unix/Linux environments and using HPC/cloud-based pipelines
•    Experience writing code using good programming principles (refactoring, unit testing, version control)
•    Strong organizational skills for handling large and complex datasets
•    Ability to collaborate effectively in a multidisciplinary research team
•    Excellent oral and written communication skills

Preferred Skills 
•    Knowledge of spatial transcriptomics technologies (e.g., Visium, CosMx, MERSCOPE)
•    Familiarity with Linux system administration with networking
•    Familiarity with database management (SQL)
•    Familiarity with machine learning / AI for genomic data analysis

 

Physical Requirements
Standing Occasionally (3-33%) Walking Occasionally (3-33%) Sitting Constantly (67-100%) Lifting Occasionally (3-33%) 20lbs - 35lbs Carrying Occasionally (3-33%) 20lbs - 35lbs Pushing Rarely (Less than 2%) Pulling Rarely (Less than 2%) Climbing Rarely (Less than 2%) Balancing Occasionally (3-33%) Stooping Occasionally (3-33%) Kneeling Rarely (Less than 2%) Crouching Rarely (Less than 2%) Crawling Rarely (Less than 2%) Reaching Occasionally (3-33%) Gross Manipulation (Handling) Constantly (67-100%) Fine Manipulation (Fingering) Frequently (34-66%) Feeling Constantly (67-100%) Foot Use Rarely (Less than 2%) Vision - Far Constantly (67-100%) Vision - Near Constantly (67-100%) Talking Constantly (67-100%) Hearing Constantly (67-100%)

 

Hybrid

 

149 Thirteenth Street Building 149

 

40

 

Regular

 

Day (United States of America)

Pay Range

$73,798.40 - $107,400.80/Annual

Grade

6
At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.
The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

 

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