Owns end-to-end HR operations for a growing two-country biotech, including HR systems, payroll coordination, benefits and total rewards, compliance, talent acquisition, employee relations, leave administration, vendor management, and executive reporting. Partners with leadership to advise managers, improve HR processes, maintain employment policies, and scale people infrastructure across U.S. and Swiss operations.
Associate Director, Human ResourcesCompany OverviewRepertoire Immune Medicines is a clinical-stage biotechnology company harnessing the power of the human immune system to develop transformative therapies for cancer and autoimmune disease. Using its proprietary DECODE™ platform — which maps the immune synapse between T cell receptors (TCRs) and their antigen targets — Repertoire translates unique biological insights into potent and targeted off-the-shelf immune medicines. The company integrates deep protein engineering expertise with artificial intelligence, powered by a proprietary DECODE database of over one billion TCR-antigen interactions, to accelerate discovery and optimize drug candidates.
From its sites in Watertown, Massachusetts and Zurich, Switzerland, Repertoire is advancing a pipeline of T cell-targeted immunotherapies with the potential to address a broad range of cancers and autoimmune disorders. The company's lead oncology program, RPTR-1-201, a TCR bispecific, has initiated a Phase 1/2 clinical trial across multiple solid tumor indications. Repertoire plans to advance additional TCR bispecific therapies into clinical trials over the next 12-18 months. In autoimmune disease, Repertoire is partnering with leading pharmaceutical companies to develop mRNA tolerizing therapies designed to selectively expand regulatory T cells and reset the immune system.
Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base. The DECODE platform has been validated through four strategic partnerships with leading pharmaceutical companies — Bristol Myers Squibb, Genentech, Eli Lilly, and Pfizer — representing over $4.5 billion in disclosed total deal value and $185 million in upfront payments received to date.Role OverviewThe Associate Director, Human Resources is the second member of the HR function and partners directly with the VP of Human Resources to build, operate, and scale the people infrastructure of a growing, two-country biotech. This on-site role holds end-to-end accountability for HR operations, benefits and total rewards administration, employment compliance, talent acquisition, and day-to-day business partnership with functional leaders and their teams.
This is a broad, hands-on role. The Associate Director executes transactional work — Form I-9 completion, interview scheduling, benefits reconciliation, HRIS data entry — while designing the processes, policies, and systems that will allow the function to scale. Success in this role requires a professional who is equally comfortable conducting a payroll audit and advising a VP on team dynamics.Key ResponsibilitiesHR Operations & Systems Management
From its sites in Watertown, Massachusetts and Zurich, Switzerland, Repertoire is advancing a pipeline of T cell-targeted immunotherapies with the potential to address a broad range of cancers and autoimmune disorders. The company's lead oncology program, RPTR-1-201, a TCR bispecific, has initiated a Phase 1/2 clinical trial across multiple solid tumor indications. Repertoire plans to advance additional TCR bispecific therapies into clinical trials over the next 12-18 months. In autoimmune disease, Repertoire is partnering with leading pharmaceutical companies to develop mRNA tolerizing therapies designed to selectively expand regulatory T cells and reset the immune system.
Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base. The DECODE platform has been validated through four strategic partnerships with leading pharmaceutical companies — Bristol Myers Squibb, Genentech, Eli Lilly, and Pfizer — representing over $4.5 billion in disclosed total deal value and $185 million in upfront payments received to date.Role OverviewThe Associate Director, Human Resources is the second member of the HR function and partners directly with the VP of Human Resources to build, operate, and scale the people infrastructure of a growing, two-country biotech. This on-site role holds end-to-end accountability for HR operations, benefits and total rewards administration, employment compliance, talent acquisition, and day-to-day business partnership with functional leaders and their teams.
This is a broad, hands-on role. The Associate Director executes transactional work — Form I-9 completion, interview scheduling, benefits reconciliation, HRIS data entry — while designing the processes, policies, and systems that will allow the function to scale. Success in this role requires a professional who is equally comfortable conducting a payroll audit and advising a VP on team dynamics.Key ResponsibilitiesHR Operations & Systems Management
- Own and optimize HR systems (ADP, JazzHR ATS, and related platforms), ensuring data integrity, audit readiness, and regulatory compliance across both sites.
- Manage full employee lifecycle processes including onboarding, offboarding, promotions, job changes, immigration and visa processing, and benefits enrollment.
- Partner with Finance on semi-monthly U.S. payroll processing and reconciliations, and with Swiss leadership on payroll adjustments as needed.
- Develop HR dashboards, people analytics, and executive reporting for the VP of HR and leadership.
- Own and maintain the HR Compliance Calendar ensuring timely filings, notices, audits, and regulatory actions.
- Ensure U.S. compliance with wage and hour laws, ERISA, ACA, COBRA, I-9, E-Verify, Workers' Compensation, Massachusetts Paid Family and Medical Leave, and salary range transparency requirements.
- Working with Swiss leadership, ensure compliance with Swiss employment law, including written employment contracts, and working time and vacation entitlements.
- Own the employee handbook and HR policies, working with outside counsel in both countries to keep them current with evolving federal and state regulations and to mitigate risk.
- Manage day-to-day benefits administration, vendor relationships, and open enrollment across U.S. health and welfare plans and Swiss pension and insurance programs, including file feed accuracy.
- Coordinate 401(k) administration, including contributions, compliance testing support, and audit responses.
- Support the VP of HR on compensation and benefits benchmarking within biotech and life sciences, annual compensation planning, job architecture mapping, and merit and equity cycle preparation in partnership with Finance.
- Support the VP of HR in managing full-cycle recruiting including intake, sourcing strategy, screening, interview coordination, offer development, and closing.
- Manage agency and search partner relationships, including terms, performance, and cost.
- Track and report talent metrics including time-to-fill, offer acceptance, and source effectiveness.
- Serve as a trusted HR business partner, advising and coaching managers on talent and performance management, employee development, team effectiveness, and conflict resolution.
- Manage the full leave-of-absence process through a third-party administrator, ensuring legal compliance and a positive employee experience.
- Support leadership development, employee engagement, and core values programs and initiatives.
- Manage HR vendor contracts and relationships including benefits brokers, HR technology providers, search firms, and fiduciary partners; generate purchase orders and coordinate invoice processing with Finance.
- Identify operational inefficiencies and automate or eliminate manual work so functional capacity scales faster than headcount.
- 8+ years of progressive HR experience, including substantive HR Operations and business partnership experience; biotech or life sciences industry experience strongly preferred.
- Strong knowledge of federal and state employment laws and ERISA regulations; Swiss or European HR experience preferred.
- Advanced proficiency in HRIS platforms (ADP preferred) and Microsoft Excel (PivotTables, XLOOKUP, data analysis, reporting).
- Sound judgment on confidential and sensitive matters; high standard of discretion and documentation.
- Strong analytical, problem-solving, communication, and stakeholder management skills.
Repertoire is committed to building an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, we believe our best work comes from a diverse workforce—and we are committed to pursuing that in all facets of the work experience.
Repertoire is proud to be an Equal Opportunity Employer.
Recruitment & Staffing Agencies: Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.Repertoire Immune Medicines Cambridge, Massachusetts, USA Office
Cambridge, MA, United States
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