Jobs at Vertex Pharmaceuticals

Lead and manage deviation and QMS activities for internal cell & gene manufacturing. Oversee investigations (OOS/OOT), root cause analysis, CAPA, change control, and audit readiness. Provide on‑floor quality support, partner cross-functionally (Manufacturing, QC, MSAT, Supply Chain, Regulatory), drive continuous improvement, track metrics, and ensure regulatory compliance (cGMP, FDA/EMA) from startup through commercialization.

Lead and deliver cross-functional process improvement and transformation across Global Regulatory Affairs using operational excellence methodologies. Design, standardize, and implement scalable GRA processes, facilitate process mapping and root-cause analysis, deploy change management and training, create documentation and KPIs, and coach teams to increase efficiency, consistency, and quality. Partner with governance and senior leaders to align improvements with corporate priorities in a global, matrixed environment.

Develop and document combination drug-device products by authoring design history files, risk analyses (DFMEA/UFMEA/PFMEA), and design inputs/outputs. Support verification/validation, change control, deviations, and cross-functional investigations. Ensure alignment with cGxP, ISO 13485/14971, 21 C.F.R.820, and statistical requirements. Collaborate with R&D, QA/QC, regulatory, packaging, and manufacturing to enable process development and product transfer.

Lead AI and automation initiatives in Real-World Data analysis, optimize processes using AI/ML, and drive project management efficiency.

Design, implement, and validate lab automation solutions (Hamilton/Biomek) to convert manual R&D processes into automated methods. Support commissioning, troubleshooting, method development, data capture, and validation across disease areas while ensuring GMP and safety compliance and driving continuous improvement.

The role involves performing specialized histology techniques and collaborating with cross-functional teams to evaluate therapeutic candidates in drug development.

Lead design and delivery of an enterprise Agentic AI Platform enabling build/bring-your-own-agents. Architect production-grade services for model integration, orchestration, lifecycle management, observability, evaluation, and performance optimization while partnering with cross-functional teams, enforcing governance and responsible AI, and mentoring engineers to translate experiments into scalable, secure production systems.

Lead RDQ learning and documentation governance: establish curriculum governance across GxP domains, partner with Global Quality Training and Documentation, assess and optimize curricula and SOP/work instruction practices, coordinate reviews and effectiveness assessments, drive harmonization, change management, and inspection readiness across cross-functional stakeholders.

Provide legal and compliance counsel for Vertex's global Compliance Program, advising business and cross-functional teams on pharma regulatory and anti-corruption laws, developing policies, training, monitoring, investigations, and continuous improvement to drive ethical decision-making and protect company integrity.

Design and build polished frontend experiences and workflow visualizations for VaiDA, Vertex's enterprise AI platform. Lead UX engineering strategy, prototype and implement interaction designs, develop reusable UI components and design standards, collaborate across product/AI/backend teams, advocate usability and accessibility, and mentor engineers to scale intuitive, data-rich multi-agent workflows for thousands of employees.

Lead design and implementation of an enterprise agentic AI platform and centralized Control Tower. Build RAG pipelines, agent orchestration, monitoring, governance, telemetry, evaluation frameworks, and scalable infrastructure. Drive platform architecture, standards, reusable services, security and compliance, vendor evaluation, and cross-functional alignment while mentoring engineers and balancing strategic leadership with hands-on execution.

Design, build, and maintain secure, scalable integrations between an agentic AI platform and enterprise systems using MCP/A2A, APIs, webhooks, and event-driven patterns. Create reusable connectors and middleware, implement authentication/authorization and secrets management, enable data exchange for structured and unstructured sources, and ensure observability, resiliency, and compliance while partnering across product, security, and platform teams.

Lead end-to-end delivery of technology initiatives for Legal, Compliance, and Corporate Communications. Partner with stakeholders and vendors to translate business needs into scalable SaaS solutions, manage integrations, risk, change, and compliance, and contribute to roadmap, governance, and continuous improvement efforts in a regulated environment.

Lead the Customer (HCP/HCO) master data domain: own design, build, and operations of the customer master and consumption layer. Drive platform modernization, cloud migration, AI/LLM-enabled mastering, data quality, governance, stakeholder engagement, vendor management, and KPI-driven continuous improvement across Snowflake, Veeva, Salesforce, and Oracle integrations.

Serve as a technical business partner delivering and supporting COTS and custom PPM solutions. Lead evaluation, selection, implementation, lifecycle planning, vendor management, and compliance activities. Drive process improvements, align technology to business strategy, manage delivery for large complex projects, and collaborate with compliance, audit, and QA teams. Support Agile delivery and oversee outsourced/managed services.

Lead analytical method lifecycle for late-stage and commercial biologics, including remediation, validation, transfer, troubleshooting, investigations, data trending, regulatory support for INDs/BLAs, authoring technical documents, and managing vendor/CMO partnerships to ensure cGMP compliance and analytical readiness for global commercialization.

Lead and oversee execution of assurance activities for patient support programs including internal audits, monitoring, CAPA management, and quality reporting. Partner cross-functionally to ensure regulatory compliance and inspection readiness, drive continuous improvement, analyze data to identify risks, and lead a team of quality professionals to strengthen patient and provider experience.

Perform statistical analyses for clinical trials, observational studies, and RWD; design and execute statistical infrastructure; author SAPs and sample size/randomization plans; collaborate with programming and cross-functional teams to produce TFLs and CSRs; participate in data review, dissemination, and methodological publications; provide and receive mentoring on complex issues.

Provide manager-facing HR advisory support for Corporate Functions, coaching leaders on performance, conduct, workforce changes, leave/accommodation, restructures, and talent programs. Enable talent planning, program rollout, organizational health analysis, and cross-HR coordination to ensure consistent, values-aligned people decisions and scalable HR delivery.

The Senior Director, Enterprise Third Party Risk will lead risk management processes, collaborate with stakeholders, and oversee supplier risk assessments for the enterprise.