Jobs at Flagship Pioneering

Lead DMPK and bioanalytical strategy across nonclinical and clinical programs, design and oversee PK/PK-PD studies, and develop/validate bioanalytical assays. Manage CROs and external labs, support toxicology programs, author regulatory nonclinical sections, present data to stakeholders, and lead a team within cross-functional research leadership.

Lead FL110's scientific strategy and multidisciplinary teams to develop a nanopore-based protein reading platform. Define roadmaps, set technical milestones, manage cross-functional integration, mitigate technical risks, build external partnerships, contribute to IP strategy, and recruit and develop scientific talent to translate research into scalable products.

Provide high-level administrative support to a Flagship executive: manage complex calendars, coordinate meetings and communications, organize worldwide travel and expenses, support projects that advance departmental priorities, collaborate with other administrative staff, and provide backup coverage as needed. Maintain discretion, strong organization, and effective written and verbal communication.

Join our team to develop and deploy AI solutions that integrate AI, physics, and hardware for molecular biology advancements.

The Senior Counsel will manage structuring and negotiating complex pharmaceutical licensing agreements, providing strategic legal support across various teams, and staying informed on industry trends. This includes leading negotiations and advising on legal compliance, while managing outside counsel.

Support commercial assessments and competitive intelligence for biotech pipeline engagements. Build models, conduct competitive landscape analyses, develop reusable frameworks and AI-enabled tools, present findings to senior leadership, and manage end-to-end workstreams to inform investment-grade recommendations.

Lead the company's finance function—oversee accounting, GAAP financial reporting, audits, budgeting, cash management, R&D expense tracking, and compliance. Drive long-range planning, scenario modeling, fundraising support, implementation of scalable finance systems, manage external vendors, and deploy AI/automation to improve finance operations.

Lead design and ownership of an agentic orchestration platform for long-running, multi-agent scientific workflows. Architect durable, event-driven, cloud-native systems, define SDKs/APIs, deliver IaC reference implementations, optimize cost and scalability, set platform standards, and partner across modeling and product teams while mentoring engineers.

Serve as VP HR Business Partner for Flagship Labs (≈110 people). Lead HRBP team, shape talent strategy, org design, change management, performance, development, employee engagement, and partnering with TA and Talent Development to align HR solutions with business goals.

Lead and execute company-wide data, software, ML/AI and IT strategy. Build and manage a multidisciplinary team, establish data architecture and governance, deploy production software and ML workflows, oversee bespoke development and IT services, and partner with scientific teams to ensure secure, reliable, and FAIR data-driven operations.

Lead multiple AI/ML computational projects across early-stage ventures, define AI strategy, oversee method and pipeline development (including protein design, docking, LLM agents), ensure benchmarking/scaling/productionization, mentor and manage cross-functional teams, scout literature, and represent the organization to partners and conferences.

Lead architecture and implementation of AI-powered scientific products end-to-end. Design data models, APIs, deployment, observability, and maintainability. Collaborate with scientists and ML researchers, make high-stakes technical decisions, bridge research and production ML, and occasionally direct embedded contractors while owning technical output and quality.

Lead full‑stack development of customer‑facing features, own product lifecycle from design to release, build scalable AI‑enabled back‑end systems on AWS, improve CI/CD and testing, collaborate with product, design, and ML researchers, and ensure security and privacy best practices.

Lead DMPK strategy for biologics across discovery and development: design and interpret PK/BA/immunogenicity studies, guide candidate selection and dose projections, author regulatory DMPK/BA sections, oversee CROs, and collaborate with cross-functional teams and PK/PD modelers to ensure regulatory readiness.

Partner with the CEO to translate corporate strategy into operating plans, drive execution of high-priority initiatives (financing, in-/out-licensing), coordinate cross-functional workstreams, build operating rhythms, support corporate development and partnerships, and provide executive reporting and decision-support to ensure timely delivery and organizational alignment.

Develop and deploy LLM-powered ML applications for psychological wellbeing. Collaborate with psychologists to translate insights into computational systems, advance RLHF and agentic AI methods, build scalable data and training pipelines, integrate ML systems into real-world products, and communicate results to multidisciplinary teams.

Lead complex, cross-functional IT initiatives from planning through implementation. Define scope and success metrics, manage schedules, budgets, risks, vendors, and governance. Drive stakeholder alignment, change management, delivery excellence, and mentor project leaders.

The Operating Principal will lead operations and strategy in biotech firms, focusing on corporate development, team management, and aligning scientific goals with business objectives.

The Senior Engineer, AI and Automation role involves designing AI-powered systems, maintaining infrastructure, building integrations, and establishing MLOps while collaborating with various teams on enterprise applications.

The Associate Director, AI Operations & Enablement leads AI strategy execution, education, and vendor management to enhance AI adoption and impact across the organization.