Jobs at AstraZeneca

Leads global clinical and scientific strategy for a respiratory pharmaceutical asset, overseeing benefit-risk assessment, clinical development plans, studies, regulatory submissions, labeling, and clinical deliverables. Serves as the primary clinical contact for R&D and therapeutic-area leaders, influences cross-functional global teams, and provides medical expertise across scientific and commercial environments. The role also involves leading, coaching, mentoring, and managing physicians and scientists, with national and international travel as needed.

Leads technology, data, digital, and AI strategy for US Commercial functions in a regulated pharmaceutical environment. Builds executive relationships, develops capability roadmaps, prioritizes demand, manages portfolio funding and risks, and supports product launches, Market Access, Commercial Operations, Finance, and training. Drives responsible AI adoption, governance, compliance, vendor collaboration, value realization, and measurable business outcomes across commercial technology initiatives.

Execute high-throughput antibody and recombinant protein expression, purification, sample preparation, and QC using automated robotics. Operate Hamilton and Lynx systems, maintain instruments and materials, track samples in LIMS, document results, troubleshoot deviations, and deliver hundreds of molecules weekly. The role requires mammalian cell culture, aseptic transfection, protein purification, rigorous SOP adherence, and cross-functional coordination. Candidates will also support workflow improvements and emerging AI/ML and automation tools.

Leads competitive intelligence and analysis for AstraZeneca’s oncology R&D pipeline. Delivers clinical and commercial insights, evaluates the evolving oncology landscape, informs therapy-area strategy and investment decisions, and communicates recommendations to senior leadership. The role involves cross-functional leadership, strategic analysis, portfolio decision support, and building trusted internal and external relationships in a highly matrixed pharmaceutical environment.

Leads AI partnership between Clinical Development, Enterprise AI, and Regulatory teams. Prioritizes regulatory AI use cases, guides buy-versus-build decisions, establishes value metrics, and coordinates responsible, compliant AI delivery. The role connects regulatory domain experts with AI, data, IT, product, and engineering teams to develop audit-ready solutions aligned with clinical data standards, governance, infrastructure, and GxP requirements.

Conduct immunology research supporting drug discovery and therapeutic development. Characterize immune pathways in autoimmune diseases, develop and validate cellular, molecular, and protein assays, analyze complex datasets, and generate translational data using human primary and disease tissue-derived cells. Collaborate with internal teams and external partners, contribute to program strategy, lead biology activities, and publish research findings.

Leads global regulatory strategy and operations for pharmaceutical product development, commercialization, registration, and lifecycle management. Advises product teams on regulatory requirements, legislation, risk mitigation, submissions, compliance, and health-authority engagement. Collaborates across global, regional, and local regulatory functions, represents the organization in trade associations, and coaches regulatory staff.

Lead development and execution of global communications for AstraZeneca's CVRM obesity and weight-management portfolio from Phase I through launch. Create disease and asset narratives, media materials, digital/social campaigns, crisis preparedness, stakeholder engagement (internal, investors, patient groups), agency management, and measurement while partnering with cross-functional global teams.

Lead the application of agentic AI and predictive biological models to identify and validate novel drug targets. Partner with therapeutic scientists, deploy multi-agent systems, contribute to foundation model development, advise cross-functional teams, shape scientific strategy, and represent AstraZeneca through publications and collaborations.

Leads global patient safety activities across product lifecycles, including safety surveillance, signal analysis, aggregate safety reports, risk management plans, regulatory submissions, and health authority responses. Partners with medical directors and cross-functional teams, presents safety findings, ensures regulatory compliance, mentors junior staff, and drives process improvements. Requires strong scientific writing, analytical, communication, pharmacovigilance, and global regulatory expertise.

Leads oncology bioanalytical strategy and delivery across PK, PD, immunogenicity, biomarker, and related assay programs. Oversees assay design, validation, CRO partnerships, regulatory submissions, data interpretation, stakeholder alignment, and project execution across biologics, ADCs, radioconjugates, cell therapies, and small molecules. Provides scientific oversight, mentors bioanalytical leads, manages multiple projects, and contributes to publications, presentations, and strategic department initiatives.

Leads global late-stage clinical development programs in immunology and gastroenterology for clinical-stage therapies. Responsibilities include study design, clinical development planning, protocol and regulatory document development, medical monitoring, safety surveillance, investigator engagement, regulatory responses, risk mitigation, clinical study reporting, publication strategy, and leadership of global study teams and project physicians.

Develop and optimize integrated laboratory automation platforms for high-throughput antibody expression, purification, and characterization. The role combines hands-on bench science with automation engineering, including robotic method development, workflow troubleshooting, and process scaling. The scientist will support molecular and cell biology workflows, collaborate with scientists, data engineers, software developers, and global automation teams, and serve as an on-site automation expert. Responsibilities also include translating scientific processes into reliable automated solutions and expanding laboratory automation capabilities.

Lead integrated clinical development for myositis/immunology and autoimmune programs, designing and executing scientifically rigorous, commercially viable trials. Oversee study protocol, feasibility, timelines, CRO/vendor selection, regulatory submissions, cross-functional coordination, team leadership and mentoring, and ensure compliance and delivery across global development lifecycle.

Leads study-level clinical science across neuroimmunology trials, owning protocol and clinical document development, medical and data review, endpoint integrity, safety surveillance, data cleaning, regulatory support, and scientific disclosures. Partners with Study Physicians, clinical operations, pharmacovigilance, data management, biostatistics, sites, and CROs. Supports inspection-ready execution, clinical data interpretation, governance readouts, and mentorship of junior clinical scientists.

Serve as the Regulatory Affairs lead for US advertising and promotional compliance: review and approve promotional/scientific materials, liaise with FDA OPDP/APLB and submit Form 2253, advise cross-functional teams on label changes and promotional strategy, develop review processes and best practices, provide training, and monitor FDA enforcement and regulatory trends to ensure compliant product promotion.

Lead US advertising and promotional compliance for assigned products, review and approve promotional and scientific materials, liaise with FDA (OPDP/APLB), develop review processes and SOPs, provide regulatory guidance and training, advise product teams on promotion strategy, and mentor ad/promo colleagues.

Lead regulatory review and approval of US promotional, non-promotional, and scientific materials; serve as primary liaison with FDA OPDP/APLB; develop SOPs and best practices for ad/promo compliance; provide training, strategic regulatory guidance to product teams, mentor colleagues, and maintain current expertise on FDA enforcement and standards.

Leads scientific publication development and strategic publication planning for oncology pipeline products. Manages cross-functional teams and third-party providers, ensures accurate and transparent communication of clinical data, and maintains compliance with publication standards and company policies. Provides subject matter expertise, supports scientific congresses, manages external relationships, mentors colleagues, and contributes to publication strategy across multiple projects.

Leads end-to-end quality oversight for external CDMOs, CMOs, testing laboratories, and suppliers supporting pharmaceutical products. Responsibilities include cGxP compliance, quality agreements, audits, investigations, CAPA, validation, technology transfers, risk management, inspection readiness, batch disposition, supplier metrics, and cross-functional governance. The role also provides matrix leadership, drives continuous improvement, and supports regulatory submissions and commercial or late-stage clinical operations.