Jobs at Rhythm Pharmaceuticals

Supports safety science across clinical development and post-approval products, leading aggregate safety surveillance, signal detection and management, risk-benefit assessments, and safety data interpretation. Prepares global pharmacovigilance documents including PBRERs, PSURs, DSURs, and RMPs; contributes to clinical and regulatory documents; improves PV processes, compliance, and data quality; and mentors staff and vendors.

Leads global compensation strategy, benchmarking, salary structures, pay transparency, annual compensation cycles, incentive and equity programs, NQDC administration, regulatory compliance, and process improvements. Partners with HR, Talent Acquisition, Finance, and business leaders to support job evaluations, offers, promotions, pay equity, data integrity, and employee communications across a global organization.

Manages scientific publication activities across integrated publication plans, coordinating authors, vendors, internal stakeholders, submissions, documentation, timelines, budgets, and congress materials. Ensures compliance with publication standards, maintains accurate records, tracks milestones, resolves operational issues, and improves processes. The role supports medical affairs and publication teams in a pharmaceutical environment.

Provides statistical programming support for clinical studies, regulatory submissions, and integrated analyses. Develops, validates, and maintains ADaM datasets, tables, listings, figures, specifications, macros, and submission documentation using SAS and CDISC standards. Partners with cross-functional teams and vendors, supports submission readiness, resolves programming risks, improves processes, and may mentor programmers, oversee vendors, and contribute to departmental standards.

Develop, validate, and QC analysis datasets, tables, listings, and figures for clinical studies and regulatory submissions. Create ADaM specs, TLF shells, reusable macros, and submission-ready documentation (define.xml, reviewer guides). Partner with Biostatistics, Data Management, Clinical Development, and vendors; identify risks, drive process improvements, and mentor junior programmers as needed.

The Treasury Manager oversees cash operations, banking administration, compliance, financial analysis, and partnerships to optimize liquidity and streamline treasury functions.

The Head of Global Strategic Sourcing leads the strategic sourcing function, manages supplier relationships, and ensures alignment with business objectives. Responsibilities include executing sourcing vision, optimizing costs, building supplier partnerships, and establishing governance frameworks.

Provide strategic and technical leadership for analytical development and QC across the product lifecycle. Define control strategies, lead method development/validation/transfer, oversee stability and impurity programs, ensure cGMP/data integrity compliance, manage CDMO/CRO partnerships, support regulatory CMC submissions and inspections, and build a high-performing analytical organization.

Serves as statistical lead for clinical studies and program activities, supporting study design, sample size calculations, SAPs, analyses, TLFs, interim analyses, regulatory submissions, and interpretation of results. Collaborates with clinical, regulatory, safety, data management, programming, and external vendor teams. Reviews statistical outputs, ensures quality and compliance, contributes to inspection readiness, and supports process improvements in a fast-paced biotech environment.

Leads biostatistical strategy for clinical development programs, including study design, sample size calculations, protocols, SAPs, analyses, TLFs, regulatory submissions, interim analyses, and interpretation of results. Collaborates with clinical, regulatory, safety, data management, programming, and medical writing teams; oversees statistical vendors; supports publications and process improvements; and provides strategic leadership in a dynamic biotech environment.

Lead GCP/GLP/GVP quality oversight for clinical studies, manage QMS and vendor audit programs, develop SOPs and training, support regulatory inspections, review clinical and safety documents, identify and mitigate compliance risks, and partner cross-functionally to ensure GCP compliance and quality across programs.

Lead cross-functional program strategy and operations for biopharmaceutical development programs. Develop and maintain integrated plans, timelines, budgets, and risk logs; facilitate core team meetings, escalate issues to senior leadership, drive process improvements, and support decision-making across clinical development through regulatory submission.

Serve as IT business analyst for G&A functions (Legal, HR, Procurement) supporting implementation, requirements gathering, testing, change management, governance, and compliance for global systems (Ironclad, Coupa, MediSpend, ADP). Coordinate vendors, support auditors, and communicate status and risks to leadership.

Lead development and deployment of AI-driven phenotyping pipelines using EMR and real-world data to define cohorts, extract features, and validate phenotypes. Integrate clinical, genomics, and biomarker datasets, build reproducible SQL/Python/R pipelines, apply statistical genetics and rare variant analyses, and improve data infrastructure to support Genetics-led programs.

Lead end-to-end development and lifecycle management of drug-device combination products (prefilled syringes, auto-injectors). Own DHF and design controls, drive verification/validation, human factors, risk management, regulatory support, and manufacturing tech transfer. Manage cross-functional teams and external vendors/CDMOs to deliver patient-centric, compliant devices from late-stage development through commercialization.

The Director of Nonclinical Development leads and executes nonclinical strategies, manages CRO relationships, and contributes to regulatory submissions for clinical programs.