Jobs at Eli Lilly and Company

Lead population PK and PK/PD modeling across drug development programs using NONMEM or Monolix and R. Own analysis plans, regulatory-standard reports, simulations, quality review, and scientific responses on dose, regimen, and patient population. Partner cross-functionally with statistics, regulatory, medical, ADME, toxicology, and clinical development teams. Contribute to automation, AI/ML integration, reproducible workflows, and scientific communication with project teams, leadership, regulators, and external audiences.

Provides technical leadership for downstream process development and scale-up of genetic medicines. Supports tech transfer from small-scale purification to manufacturing scale, analyzes yields, chromatograms, filtration performance, and process variability, and troubleshoots unit operations. Develops technical agendas, collaborates with development teams, maintains records, interprets data, and creates SOPs, protocols, specifications, and work instructions. Requires expertise in filtration, chromatography, ultracentrifugation, and TFF.

Lead ADME and DMPK activities supporting preclinical and clinical development of genetic medicines, including gene therapies, gene editing, siRNAs, and ASOs. Design and interpret ADME, PK/PD, and toxicokinetic studies; integrate multidisciplinary data to guide drug design and delivery; prepare regulatory documentation; interact with regulatory authorities; and mentor colleagues. The role requires a Ph.D. in a related scientific field and more than five years of pharmaceutical or biotechnology ADME or PK/PD experience.

Leads cheminformatics and applied AI/ML strategy across small-molecule discovery programs. Develops methods for hit identification, hit-to-lead optimization, DNA-encoded library analysis, virtual screening, predictive modeling, and generative design. Advises senior leadership, shapes platform capabilities and portfolio decisions, builds external partnerships, mentors computational scientists, and leads cross-functional scientific initiatives advancing drug candidates.

Leads global regulatory strategy and execution for immunology medicines from candidate selection through end of lifecycle. Oversees FDA submissions and agency interactions, guides cross-functional regulatory teams, aligns regional plans, manages labeling and risk strategies, and supports global development and commercialization. Builds external stakeholder relationships, advises marketing and communications teams, mentors regulatory personnel, and represents regulatory affairs in governance forums.

Provides strategic and operational leadership for trial management across early-development gene-editing clinical programs. Leads trial management leaders, standardizes processes, harmonizes Verve and Lilly operating models, oversees global clinical program delivery, and strengthens governance, compliance, vendor performance, risk management, and inspection readiness. Partners cross-functionally across clinical development, regulatory, quality, data management, supply chain, and other functions while developing talent and driving continuous improvement.

Leads integrated preclinical ADME strategy for radioligand therapeutics discovery. The role integrates pharmacokinetics, metabolism, toxicology, pharmacology, modeling, and medicinal chemistry to guide compound design, translational studies, candidate selection, and go/no-go decisions. Responsibilities include representing ADME on cross-functional teams, establishing screening and decision frameworks, supporting regulatory readiness, improving data and automation practices, participating in governance reviews, and mentoring junior scientists.

The role requires leading pharmacometrics strategy, solving complex problems, mentoring team members, and integrating AI/ML into drug development processes.

Lead high-volume negotiation and execution of consultation agreements between Lilly ExploR&D and biotech partners. Draft, redline, amend, and finalize contracts; translate scientific scopes into precise commercial terms, work plans, deliverables, and responsibilities; and coordinate with Legal, Finance, Compliance, scientists, and leadership. Maintain deal tracking and pipeline visibility, improve contracting processes, and ensure governance standards. The role may expand into alliance management.

Leads the design, development, validation, and application of immunoassay-based biomarker methods for neuroscience and neurodegenerative disease clinical trials. Performs laboratory experiments, analyzes preclinical and clinical samples, reports assay results, and collaborates with internal stakeholders, CROs, and academic partners. Provides leadership and mentorship to biomarker research teams while supporting therapeutic molecule evaluation and clinical program integration.

The role requires engineering integrative solutions between AI and lab systems to enhance molecule discovery through automation and data connectivity. It involves prototyping, collaboration with scientists, deploying intelligent systems, and ensuring reliable lab operations.

Lead and build an in vitro pharmacology capability for neuroscience discovery. Design and validate iPSC-derived and primary cell models, run assay development and siRNA/oligonucleotide screening, provide scientific direction on target validation and candidate selection, mentor scientific teams, partner cross-functionally, and drive operational excellence and platform innovation to advance neurodegeneration and chronic pain programs.

Postdoctoral scientist will develop and apply ODE-based QSP models integrating biology, pharmacology, and preclinical/clinical data. Responsibilities include literature/data curation, model design, parameter estimation, virtual patient populations, simulations, communicating results, documentation, conference presentations, and publishing. Two-year fixed-term role with mentorship and cross-functional collaboration.

Develop and optimize nucleic acid lipid nanoparticle (LNP) formulations from small to mid-scale. Design, implement, and troubleshoot experiments; perform characterization (particle sizing, Ribogreen, osmometry, zeta potential); support scale-up for large animal studies; create SOPs and test documentation; analyze data, maintain records, and support downstream processing.

Lead ADME strategy for discovery projects by integrating ADME, PK/PD, and translational modeling to guide compound design and candidate selection. Act as ADME single-point-of-accountability on cross-functional teams, define profiling and decision funnels, support dose selection with quantitative modeling, drive assay innovation and AI adoption, maintain regulatory-ready documentation, and mentor junior scientists.

The Director leads Discovery PKPD projects for genetic medicines, develops modeling strategies, conducts studies, collaborates across teams, mentors scientists, and communicates findings.

Leads LillyDirect’s forward-looking Consumer and HCP marketing strategy, growth investments, content briefing, innovation pipeline, competitive intelligence, and partnership alignment. Sets goals, KPIs, budgets, and testing strategies; advises senior leadership on investment priorities and scales successful marketing initiatives. Manages and develops marketing talent while fostering an inclusive, high-performing culture.

Leads early clinical development and clinical pharmacology programs from preclinical planning through Phase 1 and Phase 2 studies. Designs and oversees clinical trials, protocols, biomarker studies, safety monitoring, regulatory submissions, data dissemination, and investigator collaboration. Partners with research, statistics, safety, regulatory, and commercial teams while ensuring GCP and regulatory compliance. Provides scientific leadership, supports product strategy and commercialization, engages external experts, and develops clinical research talent.

Provide strategic patent counseling for key pharmaceutical assets: develop global patent filing and prosecution strategies, assess freedom-to-operate and IP risk, advise senior management, lead projects and task-directed teams, and drive continuous improvement in patent practice.

Own end-to-end security architecture and risk posture for a strategic, AWS-heavy program protecting trade secrets and sensitive intellectual property. Lead cloud and application security reviews, threat modeling, risk assessments, control design, and risk acceptance. Develop secure reference architectures, design patterns, standards, and guidance across cloud platforms, data flows, identity, and integrations. Provide technical leadership, mentorship, and security direction while communicating risks effectively to technical, business, audit, and executive stakeholders.