Jobs at CRISPR Therapeutics

Perform GMP lab testing (in-process, release, stability, raw material, environmental and microbiological) using biochemical, molecular, biophysical, and chromatographic methods. Support analytical method transfer/validation, write/revise SOPs and reports, investigate OOS/deviations/CAPAs, use LIMS for data packets, and support QC operations at the Framingham manufacturing facility.

The Director oversees the development of novel lipid nanoparticles for RNA delivery, leading efforts in formulation, testing, and cross-functional collaboration. They drive strategic initiatives and ensure innovation in LNP research, while managing a research team.

Design, formulate, and optimize lipid nanoparticle (LNP) compositions; perform comprehensive nanoparticle characterization (size, zeta potential, morphology, encapsulation, lipid/payload quantification); develop bioconjugation strategies for targeted delivery; analyze and present experimental data; collaborate cross-functionally on formulation performance, toxicity, and efficacy studies; maintain ELNs and contribute to reports/regulatory filings; support patent interactions.

Manage site material replenishment, forecasting, and procurement to support internal manufacturing and QC schedules. Maintain Oracle SCM data, create and track purchase orders, oversee inspection queues, drive supply chain systems projects, and support cGMP compliance, vendor management, and transfers between site and third-party storage.

The Senior Engineer II leads the development and scaling of mRNA manufacturing processes, applying statistical analysis and collaborating with teams to ensure quality and efficiency in gene editing therapeutics.